Protein Alignment Vmat and Slc18b1

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_001387757.1
• Gene: Slc18b1 / 309570
• RGDID: 1306962
• Length: 455
• Species: Rattus norvegicus
• Alignment Length: 438
• Identity: 111/438 - (25%)
• Similarity: 183/438 - (41%)
• Gaps: 80/438 - (18%)

  Fly   192 PPTPCPCNKDGSEAAPLEIS-TISPEE---------------------NETYYRELEERHNELVG 234
            ||.|.....||...:..|.| .:|.|:                     ...:.:|.|::.    .
  Rat     6 PPAPAGTEGDGPGGSTGETSRRLSKEQIFVLVSAASMNLGCMMTYSILGPFFPKEAEKKG----A 66

  Fly   235 ETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLS---TIIFAF------GRSY 290
            ....:|::|...|..:||.:.:.|.....||......||   ||:|   ||:|..      |..:
  Rat    67 SNTTIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAG---MFVSGGVTILFGVLDQLPEGPIF 128

  Fly   291 LVL-FVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGL----ALGVLIGPPFGGVM 350
            :.: |:.|.:..||...:..:...:||..|.      |.:...:|.|    .||::.|||.||::
  Rat   129 IAMCFLVRIVDAIGFGAAITASSSILAKAFP------NNVATVMGSLEVFSGLGLVAGPPLGGLL 187

  Fly   351 YEFVGKSAPFLILAALALGDGLLQLFMLQPSIQKAETEPPSLKSLISDPYILIAAGAITFANMGI 415
            |:..|...||:.|..:.|....|.|.:| ||.: ::....|...|::.|.|.:.|..|...:...
  Rat   188 YQSFGYEVPFIFLGCIVLLMIPLNLCIL-PSYE-SDAGKQSFWKLVTLPKIGLIAFVIISLSSCF 250

  Fly   416 AMLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHK---IGRWFAACLGLIIIGG 477
            ..|:|:|.|:::.....:....|:.||..|:||.|.:.|||.|..|   :.:||.. .|.:|..|
  Rat   251 GFLDPTLSLFVMKKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPNLRKWFLV-FGNLITAG 314

  Fly   478 CLIF---IPM---ATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHS-------AVYGSVY 529
            |.:.   ||:   .:.:..|::.....|.:.||   |::|....::...::       :..|.|.
  Rat   315 CYMLLGPIPLLHIKSQLWLLVLVLVINGVSAGM---SIIPTFPEMLSCAYANGFEDGISTLGLVS 376

  Fly   530 ALGDVAFCVGFAVGPALSGSLVKSIGFEW---------MLFGIAILCF 568
            .|....:.||..:||.|.|.|.:.|||||         :|.|:|:..|
  Rat   377 GLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAIQGLWTLLSGVAMALF 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	111/438 (25%)
Slc18b1	NP_001387757.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		6/19 (32%)
		MFS_SLC18B1	36..425	CDD:340943	102/408 (25%)