Protein Alignment Vmat and Slc18a1

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_037284.2
• Gene: Slc18a1 / 25693
• RGDID: 3693
• Length: 521
• Species: Rattus norvegicus
• Alignment Length: 502
• Identity: 267/502 - (53%)
• Similarity: 338/502 - (67%)
• Gaps: 70/502 - (13%)

  Fly   135 RGSNRLVLVIVAIALLLDNMLLTTVVPIIPEFLYDIRHPDAPLDSFPRTP-------LTS----- 187
            |.|.:||||:|.:||||||||||.||||:|.|||.....|:. .|..|.|       |||
  Rat    17 RQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDSN-SSLHRGPSVSSQQALTSPAFST 80

  Fly   188 -------------------------NVPPPPTPCPCNKDGSEAAPLEISTISPEENETYYRE-LE 226
                                     .:|||.|.               :|..|:.|.....| ||
  Rat    81 IFSFFDNTTTTVEEHVPFRVTWTNGTIPPPVTE---------------ATSVPKNNCLQGIEFLE 130

  Fly   227 ERHNELVGETVEVGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLSTIIFAFGRSYL 291
            |       |.|.:|:||||||.:||||||.|||||:||||.||||.||:||||||::|||..:|.
  Rat   131 E-------ENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYA 188

  Fly   292 VLFVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGLALGVLIGPPFGGVMYEFVGK 356
            :|||||.|||||||.|||:|:||||..:||:.|||.||||||||||||:|:|.|||.||||||||
  Rat   189 LLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGK 253

  Fly   357 SAPFLILAALALGDGLLQLFMLQPSIQKAETEPPS-----LKSLISDPYILIAAGAITFANMGIA 416
            |:||||||.|||.||.|||.:|.||    :..|.|     |.:|:.|||||:|||:|..||||:|
  Rat   254 SSPFLILAFLALLDGALQLCILWPS----KVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVA 314

  Fly   417 MLEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHKIGRWFAACLGLIIIGGCLIF 481
            :|||:||:||:..|.:..|:.|:||||||::|||||||||.|.:|:|||..:.:|::.:|..|:.
  Rat   315 ILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLC 379

  Fly   482 IPMATSITHLIIPNAGLGFAIGMVDSSMMPELGYLVDIRHSAVYGSVYALGDVAFCVGFAVGPAL 546
            :|:|.:|..||.|||||||||||||||:||.:|||||:||::|||||||:.|||||||||:||:.
  Rat   380 VPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPST 444

  Fly   547 SGSLVKSIGFEWMLFGIAILCFMYAPLLTLLKNPPTSDEKKVRMARE 593
            .|.:|:.|||.|::..|..:..:||||...|:|||..:||:..:::|
  Rat   445 GGVIVQVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEKRAILSQE 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	257/479 (54%)
Slc18a1	NP_037284.2	MFS_SLC18A1_2_VAT1_2	127..475	CDD:340942	221/358 (62%)