Protein Alignment Vmat and SLC18B1

DIOPT Version :10

• Sequence 1: NP_001014525.1
• Gene: Vmat / 3346192
• FlyBaseID: FBgn0260964
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_439896.1
• Gene: SLC18B1 / 116843
• HGNCID: 21573
• Length: 456
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 121/505 - (23%)
• Similarity: 201/505 - (39%)
• Gaps: 139/505 - (27%)

  Fly   116 EDPRA------AGSWAAAKSWMVSWRGSNRLVLVIVAIALL-LDNMLLTTVVPIIPEFLYDIRHP 173
            |.|||      |||......|:     |...|.|:::.|.: |.:|:           .|.|..|
Human     8 EGPRAPGGDDPAGSAGETPGWL-----SREQVFVLISAASVNLGSMM-----------CYSILGP 56

  Fly   174 DAPLDSFPRTPLTSNVPPPPTPCPCNKDGSEAAPLEISTISPEENETYYRELEERHNELVGETVE 238
            ..|.::                   .|.|:.      :||
Human    57 FFPKEA-------------------EKKGAS------NTI------------------------- 71

  Fly   239 VGLLFASKAFVQLLVNPIVGPLTHRIGYSIPMFAGFVIMFLS---TIIFAF------GRSYLVL- 293
            :|::|...|..:||.:.:.|.....||......||   ||:|   ||:|..      |..::.:
Human    72 IGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAG---MFVSGGVTILFGVLDRVPDGPVFIAMC 133

  Fly   294 FVARALQGIGSSCSSVSGMGMLADRFTDDKERGNAMGIALGGL----ALGVLIGPPFGGVMYEFV 354
            |:.|.:..:..:.:..:...:||..|.      |.:...||.|    .||:::|||.||.:|:..
Human   134 FLVRVMDAVSFAAAMTASSSILAKAFP------NNVATVLGSLETFSGLGLILGPPVGGFLYQSF 192

  Fly   355 GKSAPFLILAALALGDGLLQLFMLQPSIQKAETEP--PSLKSLISDPYILIAAGAITFANMGIAM 417
            |...||::|..:.|....|.:::| |:.   |::|  .|...||:.|.:.:.|..|...:.....
Human   193 GYEVPFIVLGCVVLLMVPLNMYIL-PNY---ESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGF 253

  Fly   418 LEPSLPLWMVDNMGATRWEQGVAFLPASISYLIGTNLFGPLGHK---IGRWFAACLGLIIIGGCL 479
            |:|:|.|::::.........|:.||..::||.|.:.|||.|..|   :.:|... .|.:|..||.
Human   254 LDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLV-FGNLITAGCY 317

  Fly   480 IFI-PMATSITH---------LIIPNAGLGFAIGMVDSSMMPELGYLVDIRHS-------AVYGS 527
            :.: |:  .|.|         ||:..:||  :.||   |::|....::...|.       :..|.
Human   318 MLLGPV--PILHIKSQLWLLVLILVVSGL--SAGM---SIIPTFPEILSCAHENGFEEGLSTLGL 375

  Fly   528 VYALGDVAFCVGFAVGPALSGSLVKSIGFEW---------MLFGIAILCF 568
            |..|....:.:|..:||.|.|.|.:.|||||         ::.|:|:..|
Human   376 VSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLF 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Vmat	NP_001014525.1	MFS_SLC18A1_2_VAT1_2	141..578	CDD:340942	112/474 (24%)
SLC18B1	NP_439896.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24		7/15 (47%)
		MFS_SLC18B1	37..426	CDD:340943	110/471 (23%)