DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vkor and VKORC1

DIOPT Version :9

Sequence 1:	NP_001014533.1	Gene:	Vkor / 3346188	FlyBaseID:	FBgn0053544	Length:	152	Species:	Drosophila melanogaster
Sequence 2:	NP_001298240.1	Gene:	VKORC1 / 79001	HGNCID:	23663	Length:	191	Species:	Homo sapiens

Alignment Length:	167	Identity:	57/167 - (34%)
Similarity:	81/167 - (48%)	Gaps:	37/167 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ICVCGLAISVYSLYVKMKLKEDENYRPMCDVNDNISCSLVFKSGYGDGFG-----LGNITQVNAP 73
            :|:.||.:|:|:|:||.....|.:||.:|||...||||.||.|.:|.|||     ||..:.:|..
Human    15 LCLTGLVLSLYALHVKAARARDRDYRALCDVGTAISCSRVFSSRWGRGFGLVEHVLGQDSILNQS 79

  Fly    74 NGAIGCAFYILYFLSSFFNH----------------------------RWLCLVQLIVCTLTLLL 110
            |...||.||.|..|....:.                            ||..::.|:...::|..
Human    80 NSIFGCIFYTLQLLLEMVSRHVAQAGLKQSVCLSLPKCWGDYRRCLRTRWASVLMLLSSLVSLAG 144

  Fly   111 CVYLGFLLILVFYDFCLVCVTIYFIHT---WL-FQEV 143
            .|||.::|..|.||||:||:|.|.|:.   || |::|
Human   145 SVYLAWILFFVLYDFCIVCITTYAINVSLMWLSFRKV 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vkor	NP_001014533.1	VKOR_euk	9..135	CDD:240600	52/153 (34%)
VKORC1	NP_001298240.1	VKOR_euk	10..177	CDD:240600	54/161 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149495
Domainoid	1	1.000	108	1.000	Domainoid score	I6433
eggNOG	1	0.900	-	-		E1_2CUJS
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11416
Inparanoid	1	1.050	108	1.000	Inparanoid score	I4920
Isobase	1	0.950	-	0	Normalized mean entropy	S6587
OMA	1	1.010	-	-		QHG56761
OrthoDB	1	1.010	-	-		D1611169at2759
OrthoFinder	1	1.000	-	-		FOG0004048
OrthoInspector	1	1.000	-	-		otm41842
orthoMCL	1	0.900	-	-		OOG6_104802
Panther	1	1.100	-	-	O	PTHR14519
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4888
SonicParanoid	1	1.000	-	-		X2796
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750