DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment U3-55K and Tep1

DIOPT Version :9

Sequence 1:	NP_001014529.1	Gene:	U3-55K / 3346176	FlyBaseID:	FBgn0053505	Length:	484	Species:	Drosophila melanogaster
Sequence 2:	NP_033377.1	Gene:	Tep1 / 21745	MGIID:	109573	Length:	2629	Species:	Mus musculus

Alignment Length:	379	Identity:	92/379 - (24%)
Similarity:	142/379 - (37%)	Gaps:	90/379 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 LSEIEKQEAERAEDRELAQSVEQ----RLQTEYLDSVGKLRRNIAGSLKACESSRILKHKLHHTP 162
            ||..:|.....|..|||..:..:    ||....|.:...:.   |..|..|...|     .|..|
Mouse  2015 LSRYQKPVLGLAASRELMAAASEDFTVRLWPRQLLTQPHVH---AVELPCCAELR-----GHEGP 2071

  Fly   163 ICALALSPDGKFLYTGAKSQFLLKWCTETGKVLEKSDVLSHREEPETGKKRRSHVISICLSSDMK 227
            :|..:.||||..|.|..:.:.||.|..:    :.::.:|             .|..|.|
Mouse  2072 VCCCSFSPDGGILATAGRDRNLLCWDMK----IAQAPLL-------------IHTFSSC------ 2113

  Fly   228 YLALAEGGPHIQIWCPQTMKHIKTLKGHRDSVAGLVFRKGTHDLYSAAKDRSVKIWSLDEMAYVE 292
                                       |||.:.|..:.| .:.|.|.:.|.||.:|:.:....:.
Mouse  2114 ---------------------------HRDWITGCAWTK-DNILVSCSSDGSVGLWNPEAGQQLG 2150

  Fly   293 SLFGHQTAVTSIDALSRERAITAGGSDCSLRIWKITEESQLIYNGHKDSI-ECVKYI-------- 348
            ...|||:||:::.|:  |..|.:...|.:|::|............|...| :|...:
Mouse  2151 QFSGHQSAVSAVVAV--EEHIVSVSRDGTLKVWDHQGVELTSIPAHSGPISQCAAALEPRPGGQP 2213

  Fly   349 -NDEHFVSGGMDGAIGLWSALKKKPICTTQLAHGVGENGVANWITAIAVVVNTDLVATGSCDGCV 412
             ::...|:.|:|||..||     .|:...|:....|.:|.   :||.|....:.|:.| |.|..|
Mouse  2214 GSELLVVTVGLDGATKLW-----HPLLVCQIRTLQGHSGP---VTAAAASEASGLLLT-SDDSSV 2269

  Fly   413 RLWQTNPNARKMNLIQSISIAGFINGLAFNADGSKLFVATGQE-HRLGRWWRLK 465
            :|||....|......:| |:|  |..:|:..|||  .|.:|.| ..|..|.:.|
Mouse  2270 QLWQIPKEADDSYKPRS-SVA--ITAVAWAPDGS--MVVSGNEAGELTLWQQAK 2318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
U3-55K	NP_001014529.1	Upf2	55..>125	CDD:281974	7/26 (27%)
		WD40	<150..484	CDD:225201	79/327 (24%)
		WD40	156..416	CDD:295369	61/269 (23%)
		WD40 repeat	163..203	CDD:293791	11/39 (28%)
		WD40 repeat	218..254	CDD:293791	2/35 (6%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	302..336	CDD:293791	6/33 (18%)
		WD40 repeat	342..379	CDD:293791	11/46 (24%)
		WD40 repeat	391..431	CDD:293791	13/39 (33%)
		WD40 repeat	436..461	CDD:293791	9/25 (36%)
Tep1	NP_033377.1	TEP1 N-terminal 1	1..30
		TEP1_N	1..29	CDD:283129
		TEP1 N-terminal 2	31..60
		TEP1_N	31..59	CDD:283129
		TEP1 N-terminal 3	61..90
		TEP1_N	62..89	CDD:283129
		TEP1 N-terminal 4	91..120
		TEP1_N	91..119	CDD:283129
		TROVE	230..685	CDD:283406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..412
		DUF4062	917..1017	CDD:290011
		NACHT	1171..1346	CDD:283404
		WD 1	1420..1462
		WD 2	1681..1720
		WD40 repeat	1687..1723	CDD:293791
		WD 3	1723..1761
		WD40 repeat	1729..1764	CDD:293791
		WD40	1763..2182	CDD:238121	51/227 (22%)
		WD 4	1764..1803
		WD40 repeat	1769..1804	CDD:293791
		WD 5	1805..1844
		WD40	1806..2198	CDD:225201	53/243 (22%)
		WD40 repeat	1811..1847	CDD:293791
		WD 6	1847..1886
		WD40 repeat	1852..1887	CDD:293791
		WD 7	1889..1930
		WD40 repeat	1895..1930	CDD:293791
		WD 8	1932..1971
		WD40 repeat	1937..2066	CDD:293791	13/53 (25%)
		WD 9	1974..2013
		WD40	1979..2273	CDD:238121	75/327 (23%)
		WD40 repeat	1979..2014	CDD:293791
		WD 10	2015..2054		10/38 (26%)
		WD 11	2067..2106		12/42 (29%)
		WD40 repeat	2072..2111	CDD:293791	12/55 (22%)
		WD 12	2113..2151		12/71 (17%)
		WD40 repeat	2118..2141	CDD:293791	7/23 (30%)
		WD 13	2154..2191		11/38 (29%)
		WD40 repeat	2159..2190	CDD:293791	7/32 (22%)
		WD 14	2193..2241		12/52 (23%)
		WD40 repeat	2198..2243	CDD:293791	11/49 (22%)
		WD 15	2244..2282		14/41 (34%)
		WD40 repeat	2250..2272	CDD:293791	8/22 (36%)
		WD 16	2285..2324		14/39 (36%)
		WD40 repeat	2290..2322	CDD:293791	11/31 (35%)
		WD 17	2326..2362
		WD40 repeat	2330..2374	CDD:293791
		WD 18	2375..2424
		WD40 repeat	2380..2410	CDD:293791
		WD40	2408..>2625	CDD:225201
		WD40 repeat	2420..2465	CDD:293791
		WD 19	2467..2507
		WD40 repeat	2472..2495	CDD:293791
		WD40	<2534..>2602	CDD:295369
		WD 20	2555..2592
		WD 21	2594..2628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910