DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and SYTL5

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_001156806.1	Gene:	SYTL5 / 94122	HGNCID:	15589	Length:	752	Species:	Homo sapiens

Alignment Length:	673	Identity:	214/673 - (31%)
Similarity:	321/673 - (47%)	Gaps:	97/673 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  3080 QLSQLDRDNSSSASALAVAKRRSAGD------LLFSQHQQSLSRE----QLDRVRSCGSIGGGDA 3134
            |..:..|.::..:....||.::::.|      .|.|:.:.:...|    :.|..||. |:.....
Human   154 QSQEQTRQDAEKSDTSPVAGKKASHDGPKRKGFLLSKFRSATRGEIITPKTDTGRSY-SLDLDGQ 217

  Fly  3135 HHHQLESSPAKPWLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNP 3199
            |...|:|.|        ||..|                 .|.|||  .:.|..|.|:  |:|...
Human   218 HFRSLKSPP--------GSDRG-----------------STGSSD--LNDQEPGPRT--PKSSRS 253

  Fly  3200 NQVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTPS-NLSTVSATGSAKSARYRSPGLAARA 3263
            |.|...|.|.|        ||.|.|..:..........| :|:.:..|....:..:|.......:
Human   254 NGVTPGTQSSP--------APSTRTVTSVISREYGFENSMDLAAIEGTSQELTKSHRRNTSGTPS 310

  Fly  3264 AAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMSA---------EEAKVAAE 3319
            .|||          |...||..:..:|.....|.....|.....:.|.         ||.:.:.:
Human   311 IAVS----------GTSLSSDQSRSELDLSESFTEDSEDTVSIRSKSVPGALDKDSLEETEESID 365

  Fly  3320 ELSRSPVIGQRQADGSGSPIQSRASSE-TWPTQSDEDIDRLVAMHQNRSSLSSLGVRSESMASVY 3383
            .|..|.:........||....|:|.|: .|...:..|.|         |..:||    .||.|||
Human   366 ALVSSQLSTNTHRLASGLSTSSQAGSDRKWTYLNVPDAD---------SDTTSL----NSMMSVY 417

  Fly  3384 SGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKA 3448
            |..|:  ||.|.|.|::...:.|.||...|.:.|..|::||..|.|:.|:|.|||.|||||||:.
Human   418 SETGD--YGNVKVSGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTDAYVKSYLLPDKSRN 480

  Fly  3449 GKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNP 3513
            .|||||::..| ||.|:||:::....:.||:|||.|:|||.|.||||.|||||.:......|:||
Human   481 NKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFENP 544

  Fly  3514 QSQWYLLQERSEPFDEVA-TYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSV 3577
            ..:|::||.:.|...::. .|:|::.|.|:|||||   .:.......:.|:.        :.|..
Human   545 TDEWFVLQPKVEFAPDIGLQYKGELTVVLRYIPPE---ENLMLPPEQLQGNK--------TFKKG 598

  Fly  3578 ASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNY 3642
            ..|......||.|.|.:||||:|:.:|:.||.|:|.|.|||||.::::|.||.|:|::::|.||:
Human   599 KKKESPVISGGILEVFIKEAKNLTAVKSGGTSDSFVKGYLLPDDSKATKHKTLVIKKSVNPQWNH 663

  Fly  3643 TFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQN 3707
            ||::..:..:::....||||:||.:..:||.|:||:|.:.|:|.|:|:.|:|||:.|:|..|||.
Human   664 TFMFSGIHPQDIKNVCLELTIWDKEAFSSNIFLGGVRLNSGSGVSHGKNVDWMDSQGEEQRLWQK 728

  Fly  3708 MLDRPNFWVEGSLVLRSSLDGIR 3730
            |.:.|....||.|:||||:...|
Human   729 MANNPGTPFEGVLMLRSSMGKCR 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	57/121 (47%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	71/188 (38%)
SYTL5	NP_001156806.1	PHD_SF	11..123	CDD:328929
		FYVE_Slp5	62..108	CDD:277305
		CEP170_C	<159..>309	CDD:317681	40/187 (21%)
		C2A_SLP-4_5	429..552	CDD:175995	57/123 (46%)
		C2B_SLP_1-2-3-4	566..744	CDD:175987	71/188 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I5023
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004380
OrthoInspector	1	1.000	-	-		otm42155
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45716
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9482
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	6.040