Protein Alignment btsz and SYTL3

DIOPT Version :9

• Sequence 1: NP_001247109.1
• Gene: btsz / 3346167
• FlyBaseID: FBgn0266756
• Length: 3734
• Species: Drosophila melanogaster
• Sequence 2: NP_001229313.1
• Gene: SYTL3 / 94120
• HGNCID: 15587
• Length: 610
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 157/569 - (27%)
• Similarity: 261/569 - (45%)
• Gaps: 99/569 - (17%)

  Fly  3173 YETDSSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTP 3237
            ||    :.|.....||...|:     ..|::.|...|.::      :.:..||...|:|..:.:|
Human   121 YE----ERAKKFPTGGKHETV-----GGQLLQSYQKLSKI------SVVPPTPPPVSESQCSRSP 170

  Fly  3238 SNLSTVSA-TGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFLYSKR 3301
            ..|..... .|..||.......||.....:|.:....:....:.|    ||.:...|    .::|
Human   171 GRLQEFGQFRGFNKSVENLFLSLATHVKKLSKSQNDMTSEKHLLA----TGPRQCVG----QTER 227

  Fly  3302 DARKRLNMSAEEAKVAAEEL-----------SRSPVIGQRQADGSGSPIQSRASSETWPTQSDED 3355
            .::....::....||:|.::           |.:|::.|:....|.:|
Human   228 RSQSDTAVNVTTRKVSAPDILKPLNQEDPKCSTNPILKQQNLPSSPAP----------------- 275

  Fly  3356 IDRLVAMHQNRSSLSSLGVRSESMASVYSGAGE-GRYGTVVVKGQVEFAMQYNYKLSALEVHVVR 3419
                       |::.|.|.|..|:.|:.|...| |.:....|.|::|||:.|.:|..:||:.:..
Human   276 -----------STIFSGGFRHGSLISIDSTCTEMGNFDNANVTGEIEFAIHYCFKTHSLEICIKA 329

  Fly  3420 CKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWL 3484
            ||:||..:.|:.:.:||||.|||||:|..|||||.|:::|::|.|.||:::....:.|.:|.|.:
Human   330 CKNLAYGEEKKKKCNPYVKTYLLPDRSSQGKRKTGVQRNTVDPTFQETLKYQVAPAQLVTRQLQV 394

  Fly  3485 TVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQ---WYLLQERSEPF-DEVATYRGDIVVGLKYIP 3545
            :|||.....|..|||||.:.|....|::..:|   |:.|:.::|.: |.|....|::.|..|.:.
Human   395 SVWHLGTLARRVFLGEVIIPLATWDFEDSTTQSFRWHPLRAKAEKYEDSVPQSNGELTVRAKLVL 459

  Fly  3546 PENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCD 3610
            |                  |..||    ::.....:::.|..|||.::|..||:| |::.:||.:
Human   460 P------------------SRPRK----LQEAQEGTDQPSLHGQLCLVVLGAKNL-PVRPDGTLN 501

  Fly  3611 AFCKSYL-LPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNE- 3673
            :|.|..| |||: :..:.|:||:::...|.|.::||:..|:..:|.:.:|||||||......|:
Human   502 SFVKGCLTLPDQ-QKLRLKSPVLRKQACPQWKHSFVFSGVTPAQLRQSSLELTVWDQALFGMNDR 565

  Fly  3674 FVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVL 3722
            .:||.|  ||   |.|......||.......||.:|..||.|.:.:|||
Human   566 LLGGTR--LG---SKGDTAVGGDACSLSKLQWQKVLSSPNLWTDMTLVL 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	50/124 (40%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	59/191 (31%)
SYTL3	NP_001229313.1	PHD_SF	8..123	CDD:328929	2/5 (40%)
		FYVE_Slp3	60..108	CDD:277304
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..239		2/23 (9%)
		C2A_SLP-3	307..434	CDD:176038	50/126 (40%)
		C2B_SLP_1-2-3-4	448..610	CDD:175987	59/191 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45716
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.010