DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and SYT7

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_011543637.1	Gene:	SYT7 / 9066	HGNCID:	11514	Length:	692	Species:	Homo sapiens

Alignment Length:	709	Identity:	177/709 - (24%)
Similarity:	282/709 - (39%)	Gaps:	162/709 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly  3071 NGDSRTRLSQLSQLDRD----NSSSAS-----------ALAVAKRRSAGDLLFSQHQQSLSREQL 3120
            :|..|:....::.||||    |.|:..           .|.::.....||...|.:...||..::
Human    67 SGRGRSEKKAINDLDRDFWNNNESTVQQKWSSYPPKEFILNISPYAPYGDPRLSLNGTLLSGAKV 131

  Fly  3121 D-----RVRSCGSIG---------GGDAHHHQLESSPAKPWLSSAGSSIGGDSTKDVRR------ 3165
            .     .|...|.:|         |.||    |.|..|.|....:|...|....:.|:.
Human   132 AAAAGLAVEREGRLGEKPAPVPPPGEDA----LRSGGAAPSEPGSGGKAGRGRWRTVQSHLAAGK 192

  Fly  3166 ---SSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKT 3227
               |:..|:...|.::.|:.....|..:...||:|...|                     |..:.
Human   193 LNLSNFEDSTLSTATTLESIPSSTGEPKCQRPRTLMRQQ---------------------SLQQP 236

  Fly  3228 KSQSALNHTPSNLSTVSATGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGA 3292
            .||......||..:|..:.|..::....:||...||.....|..|:|.|....|:.|.:....|:
Human   237 LSQHQRGRQPSQPTTSQSLGQLQAHMASAPGPNPRAYGRGQARQGTSAGSKYRAAGGRSRSNPGS 301

  Fly  3293 GFQFLYSKRDARKRLNM-SAEEAKVAAEELSRSPVIG-QRQADGSGSP-IQSRASSETWPTQSD- 3353
            ....:...|:  :.|:| |..|.::....|    |:| ..|.|.:..| :|:..:.:....|.|
Human   302 WDHVVGQIRN--RGLDMKSFLEGRMVVLSL----VLGLSEQDDFANIPDLQNPGTQQNQNAQGDK 360

  Fly  3354 --------------------EDIDRLVAMHQNRSSLSSL--GVRSES-MASVYSGAGEGRYGTVV 3395
                                ::.||..   :.|||:|.|  .:.||. |.|..|...|...|...
Human   361 RLPAGGKAVNTAPVPGQTPHDESDRRT---EPRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSR 422

  Fly  3396 VK-GQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHT 3459
            .. |:::|::.||::.|.|.|.:::.::|.|.|.. ..|||:||:||||||..  |.:||||:..
Human   423 ENLGRIQFSVGYNFQESTLTVKIMKAQELPAKDFS-GTSDPFVKIYLLPDKKH--KLETKVKRKN 484

  Fly  3460 LNPIFDETMRFH-TPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQER 3523
            |||.::||..|. .|...:..|.|:|.|...|.|.|||.:||||:.|........|:.|..|
Human   485 LNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDL--- 546

  Fly  3524 SEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGG 3588
             :|..:.:..||::::.|.|.|..|
Human   547 -KPCSDGSGSRGELLLSLCYNPSAN---------------------------------------- 570

  Fly  3589 QLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEE 3653
            .:.|.:.:|::|..:...||.|.:.|.:|:....|..|:||..:||.|:|.:|.:|.: |:..|:
Human   571 SIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTMKRNLNPIFNESFAF-DIPTEK 634

  Fly  3654 LSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRP 3712
            |.|..:.:||.|.|:|:.|:.:|.|..|            |....| |:..|::|:.||
Human   635 LRETTIIITVMDKDKLSRNDVIGKIYLS------------WKSGPG-EVKHWKDMIARP 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	49/122 (40%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	44/179 (25%)
SYT7	XP_011543637.1	C2A_Synaptotagmin-7	424..548	CDD:176032	50/130 (38%)
SYT7	XP_011543637.1	C2B_Synaptotagmin-7	556..691	CDD:176050	44/179 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920