Protein Alignment btsz and TCB3

DIOPT Version :10

• Sequence 1: NP_001247109.1
• Gene: btsz / 3346167
• FlyBaseID: FBgn0266756
• Length: 3734
• Species: Drosophila melanogaster
• Sequence 2: NP_013639.1
• Gene: TCB3 / 854903
• SGDID: S000004537
• Length: 1545
• Species: Saccharomyces cerevisiae
• Alignment Length: 990
• Identity: 190/990 - (19%)
• Similarity: 311/990 - (31%)
• Gaps: 338/990 - (34%)

  Fly  1981 EAVVEVEANRADGKLRDERNGRTAEQTEERVVTCSQA----CKINDNSDYSLDSLSATSASLLAP 2041
            |..||....:|.||..|| |..|.|:.|:.....||.    .||.......||:.|:.:.||
Yeast   625 EKAVERAEAKAKGKKEDE-NEDTTEKEEDENEESSQTDVGIAKITLQKVKYLDTTSSMTGSL--- 685

  Fly  2042 EQQQQQPLQQVEESARLPADAREQRYRRGAKSESAESPVENEMLNVAVASRAALLGSNNNNTHR- 2105
                       ...|.|..|.::.:..|..:  ....|..||.:.|.|.|:     ||:....:
Yeast   686 -----------SPCAELFIDGQKVKSYRTLR--RINEPSWNETIEVLVPSK-----SNSKFVLKI 732

  Fly  2106 -NDNSNN-----ENTNNNDGEL-----------GHNNND--------------AFAAQKTRNSGS 2139
             :|..|.     |.:::.|..:           |....|              ||||   .||.|
Yeast   733 FDDRMNGKALICEYSSSLDDIMTTLDTAQEFVKGSPQGDIYLDVSWKSIEMTGAFAA---ANSVS 794

  Fly  2140 SVVVGC---DISDVVSVNSNVSGENECDFDKIFGSHQQNTPSASAAVA-ATAAAATSDTPATSPS 2200
            . .:||   |:.|.: :..::||..:.|        ...|.|.:..|. .:...:.:|.|....|
Yeast   795 E-PIGCIKLDVKDAI-IKGDLSGVGDVD--------PYYTVSLNRRVLYKSIYHSDTDHPIFDNS 849

  Fly  2201 ---ELASPKNSLSAKYRSLVMINKD---------------NESAAGDYEMANSSSNFSNIRHKDP 2247
               .:.||...|:.::.....|.||               .:..:|.|...|.....|.::.||
Yeast   850 TYVPIFSPNQILTLEFHDYQKIGKDRFIGSVQIPTSNVFKKDPKSGKYVGNNGKEEISKLKLKD- 913

  Fly  2248 TSSNNSHTVGQNFASDSFRAMEPTELVSSDREAYSVDSLNEPPAVPELSVEDGLADDDSWVEELS 2312
                :.|.|.::..:.| ....|..||.|..|..:|:.|.                     :||.
Yeast   914 ----HEHKVTESIVNVS-TTFIPINLVYSPEELVNVEKLE---------------------KELK 952

  Fly  2313 QRGEDEDEDLSNATTTPTATDSEDAEGEGEGARRHGYMDREEDLRGYNRSAIDFTLHTIVEESCE 2377
            ::.:..:     ||......:.|....|.|.|......|.:|  :..||.| ..:|:.:::   :
Yeast   953 EKKKKFE-----ATQEENEQEMEKNPKEWEVAEIEDPFDSDE--KKINRKA-KLSLNELIK---Q 1006

  Fly  2378 ESEVASMR-------ADNEDVELEDEDLS------ERRRQRTLQHHHRLSASELEKYFFFGLGDG 2429
            :|.:.||:       ..:..:|:..:|:|      .:..|..|.       ||:...|...|...
Yeast  1007 KSGILSMQILEGTLSPSSAYLEILADDISYPVFICMKPSQGKLN-------SEMANIFIRDLNYS 1064

  Fly  2430 RVMSSIDTR-----GDDTASEVSSECSESLDSLPHEDQLLDTSGASDLASSRLEKYFLSGFMGFS 2489
            ::...:..:     .||..||.|....:.|.....|...|:.:|:
Yeast  1065 KLHFRVSKKHIAKDSDDVISETSYSTLKLLKQAYEEPMWLNFNGS-------------------- 1109

  Fly  2490 GAEKQAESDESGGSVGSDSEGQPSPSQRRKRLVRARGTPRSHNSSLDNLLLPESDTLDAT----- 2549
                                         |..||...||.|       :.||.|::::.|
Yeast  1110 -----------------------------KMKVRFLYTPTS-------VKLPSSESVEDTGYLNI 1138

  Fly  2550 -VTSAGGAAAATVEDTSESEAGCDDTVIHLANAGASDGSSSDTIKRKKQLRKRHDSLDEKKLHDL 2613
             :.|..|..:|       ...|..|..:|:        ..:|....|..::|:  :||
Yeast  1139 KLISGHGLKSA-------DRNGYSDPFVHI--------FVNDKKVFKSNIKKK--TLD------- 1179

  Fly  2614 EPSECRTPTPGSSGQVQMQSQAKKQQQQHHHSRDSGFVGSNDDLLKAAPDCEPPKSPTPALE--- 2675
                   |......::.:.|::|  .|...:..|....|.||||.:|:.|       ..:||
Yeast  1180 -------PVWNEDAKIPILSRSK--NQVIFNVLDWDRAGDNDDLGQASLD-------VSSLEVGK 1228

  Fly  2676 ----------------QISEDREPVHSQISLAR---MDQPSTSAAAAVASTL------------- 2708
                            |.|.:.|.:.....:.:   .|:|...|:.|..:|:
Yeast  1229 TYNWNLNLNTQGSIKLQGSFNPEYIKPSFDIVKGGITDKPMKIASGAAHATVGIAGTGIGAATGV 1293

  Fly  2709 --------SSQLKNLALPNLVRKDSFNNWSSDEETNLMMSKMRQFFKNLIVATANAQQSKPSTPN 2765
                    ...||:|....:.|..|    |:..|:|                .|.....|.|...
Yeast  1294 ATGGLKKGGHLLKSLGGNPMKRSKS----SNGNESN----------------GAKKSSEKKSFDR 1338

  Fly  2766 QGPSTTNVNTTPSSQRRLAKSRPAQLAYFENELTRLMKTVPGINDEQVREIVEYLSSEDTWSDSY 2830
            :.||  |:|:|..:.|       |.|.|        ..:||..:...|:.....:...|..|.|.
Yeast  1339 RSPS--NLNSTSVTPR-------ASLDY--------DPSVPNTSYAPVQSASPVVKPTDNTSSSS 1386

  Fly  2831 DSSDYTSSDLEGGER 2845
            :..|..||:..|..|
Yeast  1387 NKKDTPSSNSRGHSR 1401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		Atrophin-1	<299..>500	CDD:460830
		C2A_SLP	3398..3520	CDD:176056
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987
TCB3	NP_013639.1	COG5038	44..1335	CDD:227371	169/905 (19%)