Protein Alignment btsz and TCB1

DIOPT Version :10

• Sequence 1: NP_001247109.1
• Gene: btsz / 3346167
• FlyBaseID: FBgn0266756
• Length: 3734
• Species: Drosophila melanogaster
• Sequence 2: NP_014729.1
• Gene: TCB1 / 854253
• SGDID: S000005612
• Length: 1186
• Species: Saccharomyces cerevisiae
• Alignment Length: 609
• Identity: 106/609 - (17%)
• Similarity: 184/609 - (30%)
• Gaps: 258/609 - (42%)

  Fly  3285 STGKKLGAGFQFLYSKRDARKRLNMSAE-EAKVAAEELSRSPVIGQRQADGSGSPIQSRASSETW 3348
            :|||....|            .|..::: ||.:|....:|...:.:   ||.|..|.|     |.
Yeast   563 TTGKATDTG------------TLKWNSDYEAVIADRRKTRYKFVVK---DGKGEEIGS-----TI 607

  Fly  3349 PTQSDEDIDR------LVAMHQNRSSLS--------SLGVRSESMASVYSGAGEGRYGTVVVKGQ 3399
            .|.:|. |||      |:.:...:..:.        .|.:.|.|:|
Yeast   608 QTLNDL-IDRSQVNKNLIPLKNQKGDIKITTYWRPVRLEIGSNSVA------------------- 652

  Fly  3400 VEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIF 3464
                  |...:.|:.|.:.:..||..:: |....|||.||.:    :...|.:|..|..||||::
Yeast   653 ------YTPPIGAIRVFIEKANDLRNLE-KFGTIDPYCKVLV----NGLSKGRTDFKSQTLNPVW 706

  Fly  3465 DETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQ---------------------GR 3508
            ::.:  :..::|...| :.|.....:...::..|||.:||:|                     ||
Yeast   707 NQVI--YVAVTSPNQR-ITLQCMDVETVNKDRSLGEFNVNVQDLFKKDENDKYEETIDEKAKVGR 768

  Fly  3509 L-------------------------------------------------------------FDN 3512
            |                                                             ||
Yeast   769 LVMPKKKPKGTITYYTSFYPALPVLTLEEIQDLDKVNKKKKALELRKSAIDEKKISKEDKAKFD- 832

  Fly  3513 PQSQWYLLQERSEPFD--------EVATYRGDIVV-----------GL------------KYIPP 3546
              .:|..::|..:.:.        |:..|...::.           ||            :::.|
Yeast   833 --QEWNEVKELEDMYSNRQKLDLPELLQYNQGVLAVTVLNGELPDSGLYVQAFFDDNGHPRFVSP 895

  Fly  3547 ENIKSSFFSRG-----------SSIT----GSSSNLRKF-------------------------- 3570
             .|.|.....|           .|||    ..:.|..:.
Yeast   896 -RIPSRIVKNGWSGDVIIKELDKSITTFRVAKNKNYNRVEKCVCEVELPTQELVKNCYYKPSILH 959

  Fly  3571 ---GGSIKSVASKS------------ERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPD 3620
               .||.|.:...|            :..:..|.|.::.:.|::|.....||..|.:.|.|:  :
Yeast   960 LSGEGSAKLMLQISWFPIDTKQLPANDLITNSGDLTIMSRSAENLIASDLNGYSDPYLKYYI--N 1022

  Fly  3621 RTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSER---ALELTVWDHDRLASNEFVGGIRFSL 3682
            .......||.|||:||:|.||      |....:::.|   .|.:.|.|.|..::::.:|.....|
Yeast  1023 NEEDCAYKTKVVKKTLNPKWN------DEGTIQINNRLNDVLRIKVMDWDSTSADDTIGTAEIPL 1081

  Fly  3683 GTGRSYGR-----QVEWMDATGKE 3701
            ...:..|.     .||.::..|::
Yeast  1082 NKVKVEGTTELDVPVEGLENAGQD 1105

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		Atrophin-1	<299..>500	CDD:460830
		C2A_SLP	3398..3520	CDD:176056	33/203 (16%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	45/255 (18%)
TCB1	NP_014729.1	COG5038	1..1182	CDD:227371	106/609 (17%)