DRSC/TRiP Functional Genomics Resources

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Protein Alignment btsz and DOC2B

DIOPT Version :10

Sequence 1:NP_001247109.1 Gene:btsz / 3346167 FlyBaseID:FBgn0266756 Length:3734 Species:Drosophila melanogaster
Sequence 2:NP_003576.2 Gene:DOC2B / 8447 HGNCID:2986 Length:412 Species:Homo sapiens


Alignment Length:424 Identity:120/424 - (28%)
Similarity:188/424 - (44%) Gaps:104/424 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly  3323 RSPVIGQRQAD----------GSG---SPIQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGV 3374
            |||..|.|:.|          ||.   ||..|.|.....|.:.:.|.|               |.
Human    70 RSPSDGAREDDEDVDQLFGAYGSSPGPSPGPSPARPPAKPPEDEPDAD---------------GY 119

  Fly  3375 RSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKV 3439
            .|:...::               |.::|::.|:.:.:||...:.:.|.|..:| ....:|||||:
Human   120 ESDDCTAL---------------GTLDFSLLYDQENNALHCTITKAKGLKPMD-HNGLADPYVKL 168

  Fly  3440 YLLPDKSKAGKRKTKVKKHTLNPIFDETMRFH-TPISSLESRTLWLTVWHSDMFGRNDFLGEVSV 3503
            :|||..|||.|.:||..::||||.::||:.:: .....:..:||.::|...|.|..|:|:||..|
Human   169 HLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRV 233

  Fly  3504 NLQGRLFDNPQSQWYLLQERSEPFDEV----ATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSS 3564
            .|: :|..|....:.:..|:..|.|:.    ...||.|::.|||                     
Human   234 PLK-KLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRILISLKY--------------------- 276

  Fly  3565 SNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKT 3629
                              .:.|.|.|..:|:.| ||:.:.|||..|.:.|:||.||..:.||.||
Human   277 ------------------SSQKQGLLVGIVRCA-HLAAMDANGYSDPYVKTYLRPDVDKKSKHKT 322

  Fly  3630 PVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEW 3694
            .|.|:||:|.:|..|.|| :...:|::::||:||||:|...||:|:||:             |..
Human   323 AVKKKTLNPEFNEEFCYE-IKHGDLAKKSLEVTVWDYDIGKSNDFIGGV-------------VLG 373

  Fly  3695 MDATGKELSLWQNMLDRPNFWVEGSLVLRSSLDG 3728
            :.|.|:.|..|.:.|...:..:|....|.|.|.|
Human   374 IHAKGERLKHWFDCLKNKDKRIERWHTLTSELPG 407

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btszNP_001247109.1 FYVE_Slp3_4_5 26..73 CDD:277286
Atrophin-1 <299..>500 CDD:460830
C2A_SLP 3398..3520 CDD:176056 41/122 (34%)
C2B_SLP_1-2-3-4 3534..3723 CDD:175987 55/188 (29%)
DOC2BNP_003576.2 Mediates interaction with DYNLT1. /evidence=ECO:0000269|PubMed:9804756 1..90 6/19 (32%)
Negatively regulates targeting to plasma membrane. /evidence=ECO:0000250 1..36
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..123 17/67 (25%)
C2A_Rabphilin_Doc2 127..250 CDD:176000 41/139 (29%)
Mediates interaction with STXBP3. /evidence=ECO:0000250 257..375 50/171 (29%)
C2B_Rabphilin_Doc2 269..401 CDD:176030 53/185 (29%)
Blue background indicates that the domain is not in the aligned region.

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