DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and Sytl3

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_113572.1	Gene:	Sytl3 / 83672	MGIID:	1933367	Length:	607	Species:	Mus musculus

Alignment Length:	487	Identity:	146/487 - (29%)
Similarity:	229/487 - (47%)	Gaps:	93/487 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  3282 SSGSTGKKLG--AGFQ------FLYSKRDARKRLNMSAEEAKVAAEE--LSRSPVIGQRQADGSG 3336
            ||.|..::||  .||.      ||......||   :|..:..:.:|:  |:..|    ||..|.
Mouse   167 SSSSRLQELGHFRGFNKSVENLFLSVTTQMRK---LSKSQNDMTSEKHLLAMDP----RQCVGH- 223

  Fly  3337 SPIQSRASSET---WPTQSDEDIDRLVAMHQ--------------------NRSSLSSLGVRSES 3378
              .:.|:.|:|   ..::.....|.|.|.||                    ..|::.|.|:|..|
Mouse   224 --TERRSQSDTAVNVTSRKASTPDILKAFHQEDPKHPPDPVLKQDTPPSSPTHSAVFSGGLRHGS 286

  Fly  3379 MASVYSGAGE-GRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLL 3442
            :.|:.|...| |.:....|.|::|||:.|..|..:||:.:..||:||..:.|:.:.:||||.|||
Mouse   287 LISINSTCTEMGNFDNANVTGEIEFAIHYCVKSCSLEICIKTCKNLAYGEEKKRKCNPYVKTYLL 351

  Fly  3443 PDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQG 3507
            ||:|..|||||:|:|:||:|.|:||:::......|.:|.|.::|||.....|..|||||.:.|..
Mouse   352 PDRSSQGKRKTRVQKNTLDPTFEETLKYQVDPGQLMTRRLQVSVWHLGTLARRVFLGEVILPLAM 416

  Fly  3508 RLFDNPQSQ---WYLLQERSEPFDE-VATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLR 3568
            ..|.:..:|   ||.|:.::|.::| :....|::.|..|.:.|
Mouse   417 WDFKDSTAQNARWYPLRAKAEKYEENIPQNNGELAVRAKLVLP---------------------- 459

  Fly  3569 KFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVK 3633
              .|..|...::..:.:..|||.::|..||:| |::::||.::|.|..|.....:..:.|:||:|
Mouse   460 --AGPRKPQEAQEGQLALNGQLCLVVLGAKNL-PVRSDGTLNSFVKGCLTLPNQQKLRVKSPVLK 521

  Fly  3634 RTLHPSWNYTFVYEDVSLEELSERALELTVWD------HDRLASNEFVGGIRFSLGTGR--SYGR 3690
            :...|.|.::||:..||..:|.:..|||||||      :|||            ||..|  |.|.
Mouse   522 KQACPQWKHSFVFNGVSSSQLRQSTLELTVWDQAIFGMNDRL------------LGEARLGSKGG 574

  Fly  3691 QVEWMDATGKELSLWQNMLDRPNFWVEGSLVL 3722
            .....|:..:....|..:|..||.|.:.:|||
Mouse   575 AAGCPDSGSQSKLQWHRVLSSPNLWTDMTLVL 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	53/124 (43%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	54/197 (27%)
Sytl3	NP_113572.1	PHD_SF	14..123	CDD:389947
		FYVE_like_SF	60..108	CDD:333710
		DUF4195	<200..>292	CDD:372746	21/98 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..279		10/60 (17%)
		C2	306..433	CDD:387358	53/126 (42%)
		C2B_SLP_1-2-3-4	447..607	CDD:175987	54/197 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9883
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45716
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010