DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btsz and Sytl2

DIOPT Version :9

Sequence 1:NP_001247109.1 Gene:btsz / 3346167 FlyBaseID:FBgn0266756 Length:3734 Species:Drosophila melanogaster
Sequence 2:NP_001355807.1 Gene:Sytl2 / 83671 MGIID:1933366 Length:2153 Species:Mus musculus


Alignment Length:2564 Identity:546/2564 - (21%)
Similarity:929/2564 - (36%) Gaps:724/2564 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1463 TKAEPAATPATSTKGTALRVASKYQSRNLCE-------TQSAATTQTYLASKNSH-EEVEAAD-- 1517
            |:.|..|......:..||:.|.:.:.|:|.|       .::.:....|.|....| :::..||  
Mouse     8 TEEEQDAILKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADII 72

  Fly  1518 ETNIHKNQVPAAAAAATAQIQTATRAAAPAVITRFGGLAVENAVGNVAESASASAASPIPKPKPR 1582
            ..::.:.::|   |||.....||.||.             |:.|.||.:.|      .:|.....
Mouse    73 RASMRRKKLP---AAAEQNKDTAMRAK-------------ESWVNNVNKDA------VLPPEIAV 115

  Fly  1583 AQHPEQIDRHRATAETAKNLSSNRLIEN----IKMSDEASPSTAAHL--------------QSES 1629
            .:.||.        :|.....|:.|::.    |.||.|::.:.|..|              :..|
Mouse   116 VEEPED--------DTDPAGPSSSLVDPASSVIDMSQESTRTPAVSLPKQRKNPFNSPKLPEDHS 172

  Fly  1630 YAASSPDEASSNS------SQDGDQDRERE------LEEQAEQKPRRTT-----QRSYNVAGMME 1677
            ...:.|:::.:..      |::|:....:|      :..|..:||::|.     ..|:..|.:.:
Mouse   173 LQQTKPEQSKTGKAGLFQISKEGELSESKEKSSIPDMPRQQLEKPKQTVSTEPENASHTKAPIPK 237

  Fly  1678 EQQL----GEVDAVE------QRHHSTTSDSSSSSSSNSSSSSESCDSDDTGTVRDRRPKRRRFN 1732
            .::|    .:::..:      ||..|..:..:.......:|||.|.||:..           |.|
Mouse   238 ARKLIYKSNDLEKDDNQSFPRQRRDSLNARGAPRGILKRNSSSSSTDSETL-----------RLN 291

  Fly  1733 KVFVVNRQPGGRVRRSSSTEGDSLSSSEANLEDSSDNDTDTERTDCGIVLNYVKPLEEEPKKA-E 1796
                .|..|..::.....|..:.:|..|.:|||.|...:             ::||:.....| :
Mouse   292 ----YNLDPKSKILSPGLTIHERISEKEFSLEDDSSTSS-------------LEPLKHVRFSAVK 339

  Fly  1797 EEPPTAARDCQSSDEDNINDDESERRVANSTDELANCIVVVGGQTDDAAAGVVLHHMRSLPDVEF 1861
            .|.|.:.|.....:.......||: ::.|.|::        .|..::......|.|...|...:.
Mouse   340 NELPQSPRPVLGQEVGEFTVLESD-QLQNGTED--------AGDIEEFQNHPELSHKTPLSHYQL 395

  Fly  1862 DGEQSERRQAHEIDASDALAACDEL--HSISNDVNRLLALHKQNSQLELKLQRLRQGVAEINEDL 1924
            ....|:..:..|...|...|..||:  ||   |:                   |..|...:....
Mouse   396 VSSPSDSGREREQLMSSGSAPRDEIPCHS---DI-------------------LPTGPQCVESSS 438

  Fly  1925 QLSTTGTDVAATHCTTQPGSAGKPDECNSPSSRKSPSTVLSSNDVGPLSLTCLRQVEAVVEVEAN 1989
            .::  |....::|.|..|....|     |||.                .||...:.|     .:.
Mouse   439 VIN--GQQEKSSHFTKLPSELSK-----SPSD----------------ELTQCGEPE-----PSQ 475

  Fly  1990 RADGKLRDERNGR------TAE--------QTEERVVTCSQACKIND---NSDYSLDSLSATSAS 2037
            .||...||.|.|:      ||:        .||.|..|.....|:.|   .|.::.|::|:....
Mouse   476 TADHSFRDHRQGKPLLKALTAQTSSHVGPCATEIRKTTDESISKVLDWFNRSSHTEDTMSSLQHL 540

  Fly  2038 LLAPEQQQQQPLQQV------------EESARLPADAREQRYRRGAKSESAESPVENEMLNVAVA 2090
            .....:||.....|:            |:.:::|...:.:  .:..:|:.|.......:::|...
Mouse   541 QGIDLKQQTDSKAQISNALMTDNTCLEEDDSKVPMPTKVK--LKPVRSDLAFQEEGAMLVSVTCQ 603

  Fly  2091 SRAALLGSNNNN------------------THRNDNSNNENTNNND--------GELGHNNNDAF 2129
            ...|||.||:.|                  |:|..:..|||...:.        |.|..:.:|..
Mouse   604 DSDALLKSNSENLSQQGTHKEGPDTLQRFETYRIPSRRNENKGGSQGLESTEGVGTLPADGDDLL 668

  Fly  2130 AAQKTRNSGSSVVVGCDISDVVSVNSN---VSGENECDF---DKIFGSHQQNTPSASAAVAATAA 2188
            .|.|..:|.:.          |..|:|   ..|:.|.:|   .|..||...|:.|   :|....:
Mouse   669 RALKRSDSEAQ----------VPWNTNHPESLGKEETEFHLPQKSKGSTHINSDS---SVIVLGS 720

  Fly  2189 AATSDTPATSPSELAS-PKNSLSAKYRSLVMINKDNESA---AGDYEMANSSSNFSNIRHK---- 2245
            ....||...|.::..| .|:||..:..:|.:...||.|:   ..|.:.|:.......:|.|    
Mouse   721 ILKDDTERKSKTKKTSLLKSSLETENSALPLGAADNGSSWKKPEDQKEASEDPKNQVLREKYKRV 785

  Fly  2246 -DPTSSNNSHTVGQNFASD----------SFRAMEPTE-------LVSSDREAYS---------- 2282
             |..|.......|....:.          |.:|.:|.:       .:||.:..||          
Mouse   786 SDRISFWEGGKAGAKLKASQLTSSCSQQLSAKAHQPRKSQVMSLGSLSSGQSDYSEVTAKPVVFD 850

  Fly  2283 ----------VDSLNEP----PAVPELSVEDGLADDDSWVEELSQRGE------DEDE---DLSN 2324
                      .||.|:|    |.:..||....:.:....|.:|...|.      ::|.   |.||
Mouse   851 EDGQAPHLSRFDSSNKPETTRPLMSGLSKNYAVGNQSDKVTQLQTMGNETHPSLEKDRLVIDKSN 915

  Fly  2325 ATTTPTATDSEDAEGEGEGARRHGYMDREEDLRGY--------------NRSAIDFTLHTIVEES 2375
            .:....:......|...|....|...   |:||.:              |.:|.:  ..|.|..:
Mouse   916 GSFKVLSLRERMDEPNTEQVYSHSQF---ENLRKFWGLGANVNSKHNDGNNTATN--KQTSVPLN 975

  Fly  2376 CEES-EVASMRADNEDVELEDEDLSERRRQRTLQHHHRLSASELEKYFF------------FGLG 2427
            .::| |..:|:...|..:..:|.       |.|:..:.::|.|:||..|            |...
Mouse   976 IQKSKEFNAMKLSREKTQEVEEG-------RHLRQGNVIAAEEMEKLNFKCMPQEPPDETIFPQK 1033

  Fly  2428 DGRVMSSIDTRGDDT----ASEVSSECSESLDSLPHEDQLLDTS----GASDLASSRLEKYFLSG 2484
            ...:..|.:..|.:|    ...:...|||.    ..::.::.||    .:.|..:.||:|.....
Mouse  1034 TLSIEPSKENEGKNTEYFGTQVIKKACSEQ----EIQESIVKTSILPKVSKDTFNDRLQKLLAEA 1094

  Fly  2485 FM------GFSGAEKQAES---DESGGSVGSDSEG----QPSPSQRRKRLVRARGTPRSHNSSLD 2536
            .:      |....|:||..   .|:|.|...|.|.    :.||.:.::|        ...:.|:|
Mouse  1095 TLPASQTSGKEVHEQQALKVGVSENGKSFAKDEEEVTGLRESPKEPQRR--------NQQDCSVD 1151

  Fly  2537 NLLLPESDTLDATVTSAGGAAAATVEDTSESEAGCDDTVIHLANAGASDGSSSDTIKRKKQLRKR 2601
            .||...:.|..:.:.|.  ..|.|....|..:   ||.:.                  :|.:::.
Mouse  1152 KLLKESTRTPLSPLQSP--LEAVTTRPISPLK---DDLLF------------------EKWMKEN 1193

  Fly  2602 HD-SLDEKKLHDLEPSECRTPTPGSSGQVQMQSQAKKQQQQHHHSRDSGFVGSNDDLLKAAPDCE 2665
            |. |.|::        |...|.|...|   :.:.|...|:..|.:.::        :|:.|.:..
Mouse  1194 HSPSADQR--------EITAPFPQGVG---ILAGADLIQKDKHCNTEA--------MLQLAAEGS 1239

  Fly  2666 PP----------KSPTPALEQISEDRE--------PVHSQIS--LARMDQPSTSAAAAVASTLSS 2710
            ||          .|.:||...:|.|.:        |...:||  :.::..||..||..|.:.|..
Mouse  1240 PPLAQLPHCFDGVSSSPADMSLSWDAQLPSENGTLPSQKEISEAIEKVVLPSKPAATDVNAVLQK 1304

  Fly  2711 QLK-----NLALPNLVRKDSFNNWSSDEETNLM------MSKMRQFFKNLIVATANAQQSKPSTP 2764
            .|:     :..||.  |:.:....|..:..:.:      :...:.|.....|         |.|.
Mouse  1305 LLREAGEVDAKLPE--REQTAGTPSCPQRVSPLWPAPDPVVPNKDFHSFCTV---------PDTT 1358

  Fly  2765 NQGPSTTNVNTTPSSQRRLAKSRPAQLAYFENELTRLMKTV------PGINDEQVREIVEYLSSE 2823
            ::|.|..:...:||:...::.:... ..|.:..|..:.:||      |.....:.|..:|.|..|
Mouse  1359 HEGRSHLSARMSPSAHATMSPTSTV-TQYGQRLLQEVAETVRETVIQPKSQYPEFRAGLEKLLKE 1422

  Fly  2824 DTWS----DSYDSSDYTSSDLEGGERKGQLKAQISASCQ---QIINKF---EIDEEGDRGDGGLL 2878
            ...:    |..|:...:.|.|.|             ||:   |:.::|   ||.|..::.:...:
Mouse  1423 TLQTSLSKDKKDTMTISPSALTG-------------SCEMSHQLSSEFHLTEIQETVEKAEAPSV 1474

  Fly  2879 DESQ-SVPMEALVYQKLVASFSKVAAGGEPETEATKAVEEAEPSTERSPQLFAKVMQHIGTRLVA 2942
            .||. .|.:|.|: :::.....::.|.|..:|      .|.:||.........::..||      
Mouse  1475 TESSFDVGLEKLL-KEMSEGPCQLQASGRRDT------LEKQPSQVEQAGFMGEIPHHI------ 1526

  Fly  2943 LMHEVSSGNETPTPSPQGQRHHRRLQAKISATTTEDEEDEVAEQL---KAM--PIKQLKLRSKSH 3002
                    .:.|..|          :.|:|.:..|.:..:..:||   :|:  |:..::......
Mouse  1527 --------LDGPGAS----------KMKVSCSGLESQISQCDKQLGGDEAVTGPLIDVQDNKSGF 1573

  Fly  3003 DLLLDGTTPHSHHLHHHATVHYPAGGVGSGAGGSGGPGHSDNAGEECGVTSDYERFSWRGSFESA 3067
            ::.........|.:..:.|:.:                 .::.|.|..:|.:.:. |....||.|
Mouse  1574 EVPECSQLHEDHKIETNGTIQF-----------------VEDKGREKVITGETQA-SQEPGFEEA 1620

  Fly  3068 LLANGDSRTRLSQLSQLDRDNSSSAS-----ALAVAKRR--------SAGDLLFSQHQQSLSREQ 3119
            ......||.:.| :..|:....:..:     .||...:|        :..:..||....|.:||.
Mouse  1621 PKEMSVSRNKHS-IVLLETKGKAIKTREVKLVLATPYKRQEEEQGPEACSEYEFSDGNTSSNREN 1684

  Fly  3120 LDRVRSCGSIGGGDAHH----HQLESSPAKPWLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDE 3180
            .....|      .:..|    ..||...|:...|.:...|..||:...:..::|:.:..:...|:
Mouse  1685 WRNTSS------SEEEHSPVLKTLERRAARKLPSKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQ 1743

  Fly  3181 AASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTPSNLSTVSA 3245
            .|..:        |   :.|:.:...:::|.||                .:..:| |..|..:|.
Mouse  1744 KADQE--------P---DTNECIPGISTVPSLP----------------DNQFSH-PDKLKRMSK 1780

  Fly  3246 TGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMS 3310
            :..|                                              ||..:.|.|:  ..:
Mouse  1781 SVPA----------------------------------------------FLQDESDDRE--TDT 1797

  Fly  3311 AEEAKVAAEELSRSPVIGQRQADGSGSPIQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGVR 3375
            |.|:........:||           |.:.:.:||                     |.::||...
Mouse  1798 ASESSYQLRRYKKSP-----------SSLTNLSSS---------------------SGMTSLSSA 1830

  Fly  3376 SESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVY 3440
            |.|:.||||    |.:|.:.|||.|:||:.|...|..|.|.|.:||||||.|.|:.|||||||.|
Mouse  1831 SGSVMSVYS----GDFGNLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKTY 1891

  Fly  3441 LLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNL 3505
            |||||.|.||:||.|.|.||||:::|.:|:......|:::.|.|:|||.|.|.||.|||||.::|
Mouse  1892 LLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVWHRDTFKRNSFLGEVELDL 1956

  Fly  3506 QGRLFD---NPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNL 3567
            :...:|   |.|.:||.|:.::.|.......||::.:.|:|:|.                     
Mouse  1957 ETWDWDSKQNKQLKWYPLKRKTAPVALETENRGEMKLALQYVPE--------------------- 2000

  Fly  3568 RKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVV 3632
                      .|..::....|::|:.|||...| |:......::|.|..:|||.:|.|:|||..|
Mouse  2001 ----------PSPGKKLPTTGEVHIWVKECLDL-PLLRGSHLNSFVKCTILPDTSRKSRQKTRAV 2054

  Fly  3633 KRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDA 3697
            .:|.:|.:|:|.||:....|:|.|..:|||||||.:| :|:|:||:|...|||:|||.:|:|||:
Mouse  2055 GKTTNPVFNHTMVYDGFRPEDLMEACVELTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDS 2118

  Fly  3698 TGKELSLWQNMLDRPNFWVEGSLVLRSSL 3726
            |.:|::||:.|::.||.|||.:|.||..|
Mouse  2119 TSEEVALWEKMVNSPNTWVEATLPLRMLL 2147

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btszNP_001247109.1 FYVE_Slp3_4_5 26..73 CDD:277286
SOBP <300..476 CDD:291927
C2A_SLP 3398..3520 CDD:176056 64/124 (52%)
C2B_SLP_1-2-3-4 3534..3723 CDD:175987 67/188 (36%)
Sytl2NP_001355807.1 PHD_SF 5..>41 CDD:419867 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 78..98 8/35 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 116..289 32/191 (17%)
C2A_SLP-1_2 1848..1975 CDD:176039 65/126 (52%)
C2B_SLP_1-2-3-4 1988..2144 CDD:175987 67/188 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 117 1.000 Domainoid score I5918
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45716
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
44.010

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