DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and sytl1

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_001122005.1	Gene:	sytl1 / 777759	ZFINID:	ZDB-GENE-060503-439	Length:	539	Species:	Danio rerio

Alignment Length:	463	Identity:	154/463 - (33%)
Similarity:	245/463 - (52%)	Gaps:	76/463 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly  3299 SKRDARKRLNM----SAEEAKVAAEE-----LSRSPVIGQRQAD---------GSG--SPIQSRA 3343
            ::||.:..:|.    ..:|.|.:.:|     :|.:..|.|.:..         |||  ..::...
Zfish   113 AERDLQGNMNEREDDKHQEQKESGQEDGESLISNAITIPQSRTRNVTKRNEILGSGFEDSVEESE 177

  Fly  3344 SSE------TWPT---QSDEDIDR-LVAMHQNR----SSLSSLGVRSESMASVYSGAGEGRYGTV 3394
            :.|      |.||   .|:.|||. ...::..|    :||:|..:.:.|:.|:||   .|.:|.|
Zfish   178 NKERRILPSTSPTLQIDSEGDIDSGSTEINYTRFGSVTSLTSHHMMNGSLMSLYS---VGDFGDV 239

  Fly  3395 VVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHT 3459
            ||.|:::|::||:.:...|.||::||:|||:  |::||||||||||||||.:...|:||.|::.|
Zfish   240 VVSGRIQFSLQYDVRTEELYVHIIRCQDLAS--ARKNRSDPYVKVYLLPDNTSRSKKKTAVRRKT 302

  Fly  3460 LNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERS 3524
            |||::||||.:......|.:|.|.::|||.:...||.||||:.|.|....:...|..|..||.|.
Zfish   303 LNPVYDETMTYKVRRLDLPARVLSMSVWHMERMRRNLFLGELEVRLGQWDWSQNQPTWQNLQPRV 367

  Fly  3525 EPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQ 3589
            :...|....||.|:..:|::||          ||...|:.:.                     |:
Zfish   368 QLSPEAIISRGTILFSIKFVPP----------GSEGRGNPAT---------------------GE 401

  Fly  3590 LHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEEL 3654
            ||:.::|...|.|.| .|..:.:.||.:|||.:..|.|:|.||:.::.|.:|:|.||:.....:|
Zfish   402 LHIWLREIVGLLPTK-RGAPNTYVKSVVLPDESGVSGQQTRVVRGSVSPVFNHTMVYDGFQSSDL 465

  Fly  3655 SERALELTVWD-HDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEG 3718
            .:...|:|||: |    .:..:||:|.|.|:|.|||:.|.|||:|..|:::|.:::..||.||:.
Zfish   466 IQACAEITVWNPH----PSGCLGGVRLSTGSGLSYGQSVCWMDSTEDEINVWSSVIQSPNSWVDT 526

  Fly  3719 SLVLRSSL 3726
            ||.:|::|
Zfish   527 SLPIRTNL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	55/121 (45%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	60/189 (32%)
sytl1	NP_001122005.1	PHD_SF	12..>43	CDD:304600
		C2A_SLP-1_2	242..364	CDD:176039	55/123 (45%)
		C2B_SLP_1-2-3-4	377..531	CDD:175987	60/189 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45716
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010