DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and Syt7

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_006231127.1	Gene:	Syt7 / 59267	RGDID:	62013	Length:	687	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	179/732 - (24%)
Similarity:	293/732 - (40%)	Gaps:	169/732 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3037 GGPGHSDNAGEECGVTSDYERFSWRGSFESAL------------LAN-------GDSRTRLSQLS 3082
            |.|......||:..: :|.:|..|..: ||.:            :.|       ||.|..|:...
  Rat    57 GTPDSGRGRGEKKAI-NDLDRDFWNNN-ESTVQQKWSSYPPKEFILNISPYAPYGDPRLSLNGTL 119

  Fly  3083 QLDRDNSSSASALAVAKRRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAHHHQLESSPAKPW 3147
            ......:::|:.|||.:....|     :....:.....|.:||.|             ::|::|
  Rat   120 LSGAKVATAAAGLAVEREGRLG-----EKPAPVPPPGEDALRSGG-------------AAPSEP- 165

  Fly  3148 LSSAGSSIGGD--------STKDVRRSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQVVA 3204
             .|:|.:..|.        :...:..|:..|:...|.::.|:.....|..:...||:|...|
  Rat   166 -GSSGKAGRGRWRMVQSHLAAGKLNLSNFEDSTLSTATTLESIPSSAGEPKCQRPRTLMRQQ--- 226

  Fly  3205 STNSLPRLPTTGVGAPITSTPKTKSQSALNHTPSNLSTVSATGSAKSARYRSPGLAARAAAVSGA 3269
                              |..:..||:.....||..:|..:.|..::....:||...||.....|
  Rat   227 ------------------SLQQPLSQNQRGRQPSQPTTSQSLGQLQAHAASAPGSNPRAYGRGQA 273

  Fly  3270 GGGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNM-SAEEAKVAAEELSRSPVIG-QRQA 3332
            ..|:|.|....|:.|.:....|:....:...|:  :.|:| |..|.::....|    |:| ..|.
  Rat   274 RQGTSAGSKYRAAGGRSRSNPGSWDHVVGQIRN--RGLDMKSFLEGRMVVLSL----VLGLSEQD 332

  Fly  3333 DGSGSP-IQSRASSETWPTQSD---------------------EDIDRLVAMHQNRSSLSSL--G 3373
            |.:..| :|:..:.:....|.|                     ::.||..   :.|||:|.|  .
  Rat   333 DFANIPDLQNPGTQQNQNAQGDKRLPAGGKAVNTAPVPGQTPHDESDRRT---EPRSSVSDLVNS 394

  Fly  3374 VRSES-MASVYSGAGEGRYGTVVVK-GQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPY 3436
            :.||. |.|..|...|...|..... |:::|::.||::.|.|.|.|::.::|.|.|.. ..|||:
  Rat   395 LTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFS-GTSDPF 458

  Fly  3437 VKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFH-TPISSLESRTLWLTVWHSDMFGRNDFLGE 3500
            ||:||||||..  |.:||||:..|||.::||..|. .|...:..|.|:|.|...|.|.|||.:||
  Rat   459 VKIYLLPDKKH--KLETKVKRKNLNPHWNETFLFEGFPYEKVVQRILYLQVLDYDRFSRNDPIGE 521

  Fly  3501 VSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSS 3565
            ||:.|........|:.|..|    :|..:.:..||::::.|.|.|..|
  Rat   522 VSIPLNKVDLTQMQTFWKDL----KPCSDGSGSRGELLLSLCYNPSAN----------------- 565

  Fly  3566 NLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTP 3630
                                   .:.|.:.:|::|..:...||.|.:.|.:|:....|..|:||.
  Rat   566 -----------------------SIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTV 607

  Fly  3631 VVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWM 3695
            ..||.|:|.:|.:|.: |:..|:|.|..:.:||.|.|:|:.|:.:|.|..|            |.
  Rat   608 TKKRNLNPIFNESFAF-DIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLS------------WK 659

  Fly  3696 DATGKELSLWQNMLDRP 3712
            ...| |:..|::|:.||
  Rat   660 SGPG-EVKHWKDMIARP 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	50/122 (41%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	44/179 (25%)
Syt7	XP_006231127.1	C2A_Synaptotagmin-7	419..543	CDD:176032	51/130 (39%)
Syt7	XP_006231127.1	C2B_Synaptotagmin-7	551..686	CDD:176050	44/179 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920