DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btsz and SYT13

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_065877.1	Gene:	SYT13 / 57586	HGNCID:	14962	Length:	426	Species:	Homo sapiens

Alignment Length:	309	Identity:	66/309 - (21%)
Similarity:	122/309 - (39%)	Gaps:	64/309 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly  3407 NYKLSALEVHVVRCKDLAAVDAKRNRS-DPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRF 3470
            :|.....|:.|.|   |.||.:..:.. |.||: ..:.:::.:.:.:|.:||..|:..::|.:..
Human   167 DYDCQKAELFVTR---LEAVTSNHDGGCDCYVQ-GSVANRTGSVEAQTALKKRQLHTTWEEGLVL 227

  Fly  3471 HTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRG 3535
            ......|.:.||.||:...|.|.|:...||:.:.|.|.......:||..|:..::   |.:...|
Human   228 PLAEEELPTATLTLTLRTCDRFSRHSVAGELRLGLDGTSVPLGAAQWGELKTSAK---EPSAGAG 289

  Fly  3536 DIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHL 3600
            ::::.:.|:|..|                                        :|.|::.:||:|
Human   290 EVLLSISYLPAAN----------------------------------------RLLVVLIKAKNL 314

  Fly  3601 SPIKANGTC--DAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTV 3663
            ...::....  |...|..|.....:..|::|...|..::|.||...::| :..:.|...::||.|
Human   315 HSNQSKELLGKDVSVKVTLKHQARKLKKKQTKRAKHKINPVWNEMIMFE-LPDDLLQASSVELEV 378

  Fly  3664 WDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRP 3712
            ...|....:..:|  ..|||           :..:|.|.|.|:.||..|
Human   379 LGQDDSGQSCALG--HCSLG-----------LHTSGSERSHWEEMLKNP 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	29/113 (26%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	35/181 (19%)
SYT13	NP_065877.1	C2A_Synaptotagmin-13	160..277	CDD:176059	29/113 (26%)
SYT13	NP_065877.1	C2B_Synaptotagmin-13	288..425	CDD:176052	35/181 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920