DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and sytl2b

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_701277.6	Gene:	sytl2b / 572466	ZFINID:	ZDB-GENE-121214-363	Length:	1737	Species:	Danio rerio

Alignment Length:	2092	Identity:	472/2092 - (22%)
Similarity:	783/2092 - (37%)	Gaps:	619/2092 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly  1884 DELHSISNDVNRLLALHKQNSQL----ELKLQRLRQGVAEINEDLQLSTTGT---DV-AATHCTT 1940
            |..|....:...::.:.|::::|    |.:::.|::.:.|  ||.:...:|.   :| :..|...
Zfish     3 DLSHLSEEEQEMIMKVLKRDAELKKAEEDRIKHLQKAIPE--EDRRKYMSGEWFYEVKSQRHQDR 65

  Fly  1941 QPGSAGKPDECNSPSSRKSPSTV-LSSNDVGPLSLTCLRQVEAVVEVEANRADGKLRDERNGRTA 2004
            ..||    |...:...::.||.| ..:...|..|.:..|:          .::|.:...:..|||
Zfish    66 IHGS----DIIMASMKQRKPSVVEYLTKSWGGRSRSISRK----------DSEGIMTSPKITRTA 116

  Fly  2005 EQTEERVVTCSQACKINDNSDYSLDSLSATSASLLAPEQQQQQPLQQVEESARLPADAREQRYRR 2069
            |.:|.        .|..:|.|.........:..:.:|.:.:..|...|
Zfish   117 ESSEH--------LKERENGDTLEVQQEKLNIGMRSPSKPRHNPFNSV----------------- 156

  Fly  2070 GAKSESAESPVE--NEMLNVAVASRAALLGSNNNNTHRNDN---SNNENTNNNDGELGHN---NN 2126
                     |:|  .|..::...||..|..|.:..:...||   :::...|:......||   ..
Zfish   157 ---------PIELDFEETDLHYTSRPGLRKSLDRGSDSQDNHQKASHSQVNSEVSNAVHNKPPGQ 212

  Fly  2127 DAFAAQKTR-NSGSSVVVGCDISDVVSVNSNVSGENECDFDKIFGSHQQNTPSASAAVAATAAAA 2190
            .....::|: |...|.|  .|.:..||..| :|.:|      ||                    |
Zfish   213 KPVPKKRTKINKPQSSV--SDTASSVSTQS-ISSQN------IF--------------------A 248

  Fly  2191 TSDTPATSP----------------SELASPKNSLSAKYRSLVMINKDNESAAGDYEMANSSSNF 2239
            |:|:...||                |:|..|..|||..:::.:. .||:|.:.........||:.
Zfish   249 TADSSIRSPPPRGIPKHSFNEPTLKSQLRQPVVSLSNVHKNSIQ-EKDSEESKLALGRTEESSHK 312

  Fly  2240 SNIRHKDPTSSNNSHTVGQNFASDSFRAMEPTEL------VSSDREAYSV-DSLNEPPAV-PELS 2296
            :..:.|..|||                   |.:|      |.:..:..:: ..|.|.|.: |.||
Zfish   313 TENKEKCSTSS-------------------PIKLPKSRLPVRASSQLINMPQGLQEKPKIQPRLS 358

  Fly  2297 VEDGLADDDS-WVEE-LSQRGED------------EDEDLS----------------------NA 2325
            :......||| .||| :.||||.            |.:::|                      |.
Zfish   359 LNSITRPDDSRKVEEVIKQRGESNSCLPQSPSMEVERQNISVEMHHPVENAVFAFSDNSKKPLNE 423

  Fly  2326 TTTPTATD--SEDAEGEGEGARRHGYMDREEDLRGYNRSAIDFTLHTIVEE----SCEESEVASM 2384
            .|||..|.  ||:.|.:.....:...|..||.::           .|..:|    :...:|..:|
Zfish   424 ITTPQLTHHMSENVENQMAPFPKLETMKTEEKIK-----------KTTTDEHFPRALNITETFNM 477

  Fly  2385 RADNEDVELEDEDLSERRRQRTLQHHHRLSASELEKYFFFGLGDGRVMSSIDTRGDDTAS--EVS 2447
            ...:.|.|.|...|:...:|:|.....  ..||:       :.|..:.:..|.:||..|.  |..
Zfish   478 TNASTDYETESSPLAFNIKQKTSSQED--PKSEV-------MTDEHITTPTDEQGDSIAKVLEWF 533

  Fly  2448 SECSESLDSLPHEDQLLD------------TSGASDLASSRLEKYFLSGFMGFSGAEKQAESDES 2500
            |..|:|.|.|..:..:.|            ..|.......|...|.:        ..:|:|....
Zfish   534 SRSSDSSDRLDIDSNVQDMEEDSKFEDLDFDDGVDHTVKPRSNVYLI--------MPRQSEGPSE 590

  Fly  2501 GGSV--------GSDSEGQPSPSQRRKR-----------LVRARGTPRSHNSSLDNLLLPESDTL 2546
            ..::        ...|..:||.:.|::|           |::   .|...::...|::.||...:
Zfish   591 VNTIFLEQADWRKEQSVDEPSQNPRKERKTSESTFYKESLIK---KPSVDSALTANIVNPEVPVV 652

  Fly  2547 DATVT---SAGGAAAATVEDTSESEAGCDDTVIHLANAGASD----------------------- 2585
            :.:|:   .......|.::...:||....|.......:.|.:
Zfish   653 NISVSRKVQNENKVEALIKKEDKSEVKLADISQQKERSDAEENQRPKIANLKSFWEKENIGPKIL 717

  Fly  2586 -GSSSDTIKRKK----QLRKRHDSLDEKKLHDLEPSECRTPTP-----------------GSSGQ 2628
             |.|....|.::    .|.||  |.:|.:.|.......:..:|                 |::.|
Zfish   718 IGKSGAPAKNEEIIPSDLAKR--STEEIEDHWRSEPNLKVMSPGLQKIETVWKNVDIEDVGTATQ 780

  Fly  2629 VQMQSQAKKQQQQHHHSRDSGFVGSNDDLLKAAPDCEPPKSPTPALE----QISEDREPVHSQIS 2689
            |.:.....|.....:...|.....|..| .|....|  .||.:|||:    :.|.|.:.....:|
Zfish   781 VPIIINESKPLIYANQKTDKIVANSTLD-KKCTTSC--LKSSSPALDSGSLEGSHDDDSAGGTVS 842

  Fly  2690 LARMDQPSTSAAAAVASTLSSQLKNLALPNLVRKDSFNNWSSDEETNL--MMSKMRQFFKNLIVA 2752
            :...|  :..:|.....|.|...:..:....|:::|       ::.|:  .:.::|.|::
Zfish   843 INSSD--ADHSAQKELETKSKTAQKTSQGPSVKQNS-------QQENMAERIKQLRSFWE----- 893

  Fly  2753 TANAQQSKPSTPNQGPSTTNVNTTPSSQRRLAKSRPAQLAYFENELTRLMKTVPGINDEQVREIV 2817
                ::|:.|...:..|||   ||....:|..||.      |:      ::|:
Zfish   894 ----KESRTSVAAKNRSTT---TTTRLNQRFTKSE------FD------LRTI------------ 927

  Fly  2818 EYLSSEDTWSDSYDSSDYTSSDLEGGERKGQLKAQISASCQQIINKFEIDEEGDRGDGGLLDESQ 2882
               .:|....|..|..|.||:       :|:|....|                    |.||.:.:
Zfish   928 ---GTEFDDGDEDDVEDITSA-------RGRLSPNFS--------------------GHLLRKDK 962

  Fly  2883 SVPMEALVYQKLVASFSKVAA--GGEPETEATKAVEEAEPSTERSPQLFAKVMQHIGTRLVALMH 2945
            :|.|:.:.    .:.|..:..  ||.|           ..:.||||.|
Zfish   963 TVVMDGMT----TSQFKNLRDFWGGSP-----------VKTGERSPVL----------------- 995

  Fly  2946 EVSSGNETPTPSPQGQRHHRRLQAKISATTTEDEEDEVAEQLKAM--PIKQLKLRSKSHDLLLDG 3008
              .|||.. :.|||..  :.|...|.....:::.:...:.::||.  |.|: |:.|:..    .|
Zfish   996 --DSGNHR-SSSPQSP--NERANVKDFVNESQNSKTSSSAKMKAFQSPSKK-KIMSRQE----SG 1050

  Fly  3009 TTPHSHHLHHHATVHYPAGGVGSGAGGSGGPGHS--------------DNAGEECGVTSDYERFS 3059
            ..|..            :.|| ||...:.|..||              ...|:|.  .|...|.|
Zfish  1051 PKPDQ------------SQGV-SGETITHGLSHSLQPQKGSKTTMVPKSQTGQES--RSQQGRRS 1100

  Fly  3060 WRGSFESALLANGDSRTRLSQLSQLDRDNSSSASALAVAKRRSAGDLLF-SQHQQSLSREQLDRV 3123
            .:|:.      ||.:...        |..:|..|..|..:.::. ||.| |:..||.:.:|:.:.
Zfish  1101 IKGNL------NGKANAM--------RRATSMFSVNATGEEQNQ-DLHFQSKKVQSPNLQQVKKA 1150

  Fly  3124 RSCG---SIGGGDAHHHQLESSPAKPWLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDEAASHQ 3185
            ....   |....:|.:...::||...|         .|..|:.:|.:       :.:|:::.|..
Zfish  1151 PDTSLTQSRKVQEASYTLPKTSPEISW---------RDRDKNSQRRT-------SRTSEDSDSQP 1199

  Fly  3186 FGGARSTLPRSLNPNQVVASTNSLPRLPTTG------VGAPITSTPKTKSQSALNHT----PSNL 3240
            .  |||.:||.......::...|:...|...      :....||:|:|      ||:    |...
Zfish  1200 L--ARSYIPRDYQHYLGISEDKSMYTPPPVAEQVDDFICTSFTSSPET------NHSCKCPPVKT 1256

  Fly  3241 STVSATGSAKSARYRSPGLAARAAAVSGAGG-----GSSGGVGVG-------------------- 3280
            ||         ..:.||.|..|    ||:.|     .:.|.:..|
Zfish  1257 ST---------PVHGSPDLQTR----SGSLGHHLTTQTDGNIIKGIQNRENESLIQKALKRASSR 1308

  Fly  3281 ----------ASSGSTGKKLGAGFQFLYSKRDARK-RLNMSAEEAKVA-AEELSRS-PVIGQRQA 3332
                      :|.....:||.....:::...||.. .|..|...|... .::||:| |...::::
Zfish  1309 PVYHKSMEDISSIARQDQKLKQTDDYMHDNYDASSTHLQTSFSTADPEHMKKLSKSVPSFLEKES 1373

  Fly  3333 DG--SGSPIQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGVRSESMASVYSGAGEGRYGTVV 3395
            ||  |.|...||.|...|..:...::       .|.|..:||...|.|:||||:    ..|.:|.
Zfish  1374 DGGESDSESSSRGSVPKWNNRQFTNL-------SNYSGSTSLSSVSGSVASVYT----SDYNSVD 1427

  Fly  3396 VKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTL 3460
            |:|.::|::.|.:||....:.||:|::||||||||||||||||.||:||.:..|||||.|||.||
Zfish  1428 VQGSIQFSLNYVHKLREFHIFVVQCQNLAAVDAKRNRSDPYVKSYLIPDPANLGKRKTAVKKKTL 1492

  Fly  3461 NPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERS- 3524
            ||.::|.:|:...:..|.|:.|.|:.||:||||||.||||:.::|....|::.:.:...|:.|:
Zfish  1493 NPTYNEILRYRVRMEYLTSQVLNLSAWHNDMFGRNSFLGEIELDLSTWDFNDTERKLLPLKPRNL 1557

  Fly  3525 --------EPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKS 3581
                    :|.|    .:|.:.:.::::|.       .|...::.||
Zfish  1558 FIQTTNSLQPSD----LKGQMRLAIRFLPQ-------ISHSKNVPGS------------------ 1593

  Fly  3582 ERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVY 3646
                  |::|:.||:.|:| |:..:.|.|.:.|.::|||.::.|:|||.|:|||.:|.:|:|.||
Zfish  1594 ------GEVHIWVKDCKNL-PLIRSPTIDPYVKCFVLPDTSKKSRQKTRVLKRTTNPIFNHTMVY 1651

  Fly  3647 EDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDR 3711
            :....|:|.|..:||||||.|||||:. :||:|..:|||||||.||:|||:|.:|::||:.|::.
Zfish  1652 DGFRAEDLKEACVELTVWDRDRLASHS-LGGLRLGMGTGRSYGVQVDWMDSTTEEVALWRRMMNS 1715

  Fly  3712 PNFWVEGSLVLR 3723
            ||.|||..|.||
Zfish  1716 PNEWVEDILPLR 1727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	60/121 (50%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	71/188 (38%)
sytl2b	XP_701277.6	PHD_SF	5..>47	CDD:304600	8/43 (19%)
		C2	1429..1553	CDD:301316	60/123 (49%)
		C2B_SLP_1-2-3-4	1571..1727	CDD:175987	71/188 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I5598
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45716
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010