DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btsz and SYTL2

DIOPT Version :10

Sequence 1:NP_001247109.1 Gene:btsz / 3346167 FlyBaseID:FBgn0266756 Length:3734 Species:Drosophila melanogaster
Sequence 2:NP_996810.2 Gene:SYTL2 / 54843 HGNCID:15585 Length:2239 Species:Homo sapiens


Alignment Length:2666 Identity:578/2666 - (21%)
Similarity:946/2666 - (35%) Gaps:842/2666 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly  1463 TKAEPAATPATSTKGTALRVASKYQSRNLCETQSAATTQTYLASKNSHEEVEAADETNIHKNQVP 1527
            |:.|..|......:..||:.|.:.:.|:|.|   .......|.:.:.....||  :...|::::.
Human     8 TEEEQEAIMKVLQRDAALKRAEEERVRHLPE---KIKDDQQLKNMSGQWFYEA--KAKRHRDKIH 67

  Fly  1528 AAAAAATAQIQTATRAAAPAVITRFGGLAVENAVGNVAESASASAASPIPKPKPRAQHPEQIDRH 1592
            .|.....:..:...:.||.....|..| |.|:.|.||.:.|...     |:.....:.||:....
Human    68 GADIIRASMRKKRPQIAAEQSKDRENG-AKESWVNNVNKDAFLP-----PELAGVVEEPEEDAAP 126

  Fly  1593 RATAETAKNLSSNRLIENIKMSDE--ASPSTAAHLQSESYAASS--PDEASSNSSQDGDQDRERE 1653
            .:.:.:..|.:|:    .|.||.|  ..|:.:...|.::...||  |:..||..:::        
Human   127 ASPSSSVVNPASS----VIDMSQENTRKPNVSPEKQRKNPFNSSKLPEGHSSQQTKN-------- 179

  Fly  1654 LEEQAEQKPRRTTQRSYNVAGMMEEQQLGEVDAVEQRHHSTTSDSSSSSSSNSSSSSESCDSDDT 1718
              ||:  |..||        |:.:..:..|:.  |.:..||.:|:|......|..:.....:.  
Human   180 --EQS--KNGRT--------GLFQTSKEDELS--ESKEKSTVADTSIQKLEKSKQTLPGLSNG-- 228

  Fly  1719 GTVRDRRPKRRRF-----------NKVFVVNR--------QPGGRVRRSSSTEGDSLSSSEANLE 1764
            ..::...||.|:.           |:.|...|        .|.|.::|:||              
Human   229 SQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSS-------------- 279

  Fly  1765 DSSDNDTDTERTDCGIVLNYVKPLEEEPKKAEEEPPTAARDCQSSDEDNINDDESERRVANSTDE 1829
             ||..|::|.|.:...          |||.....|.....:..|..|.::.|:.|    .||.:.
Human   280 -SSSTDSETLRYNHNF----------EPKSKIVSPGLTIHERISEKEHSLEDNSS----PNSLEP 329

  Fly  1830 LANCIVVVGGQTDDAAAGVVLHHMRSLPDVEFDGEQSERRQAHEIDASDALAACDELHSISNDVN 1894
            |.:  |......|:......|.|.|.:.  ||...:|:|.:....||.|.    :|..|....  
Human   330 LKH--VRFSAVKDELPQSPGLIHGREVG--EFSVLESDRLKNGMEDAGDT----EEFQSDPKP-- 384

  Fly  1895 RLLALHKQNSQLELKLQRLRQGVAEINEDLQLSTTGT-DVAATH-----CTTQPGSAGKPDECNS 1953
                  .|..:..|..|.........:|..|..|:|: .:...|     .|.:|.|.......|.
Human   385 ------SQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINE 443

  Fly  1954 PSSRKSPSTVLSSNDVGPLSLTCLRQVEAVVEVEANRA-DGKLRDERNGRTAEQTEERVVTCSQ- 2016
            |..:.|..|.|.|  |.|.|..  .::...||.|.::. .|..||.:.|:.......:..|.|: 
Human   444 PKDKSSELTRLES--VLPRSPA--DELSHCVEPEPSQVPGGSSRDRQQGKPPPLPALKAKTSSRS 504

  Fly  2017 ---ACKINDNSDYSL---------DSLSATSASLLAPEQQQQQPLQQVEESARLPADAREQ---- 2065
               |.:|..::|.|:         .|.|..:.|.|    |..:.::..|::     |::.|    
Human   505 GPYATEIKKSTDDSIFKVLDWFNRSSYSDDNKSFL----QHPRGIESKEKT-----DSKSQVAVD 560

  Fly  2066 -------RYRRGAKSES----------AESP--VENEML--------NVAVASRAALL------- 2096
                   ....|:|:.|          ::||  .|.:||        ||.:.|:...|       
Human   561 LVTDDTTLRENGSKTLSPSKIELKPVRSDSPFQAEGDMLVSESCQDNNVNIKSKFMNLSQKGTPK 625

  Fly  2097 -------------------------------GSNNNNTHRNDN--------SNNEN----TNNND 2118
                                           |..|..:..|.|        |:.||    ..||.
Human   626 EGPGILQPFESYGTPSQGSKNMDYSQDSKSPGKGNGASPSNSNYSYSVLKESDAENQVPCNTNNI 690

  Fly  2119 GELGHNNNDAFAAQKTRNSGSSVVVGCDISDVV---SVNSNVSGENECDFDKIFGSHQQNTPSAS 2180
            |.||.......|.::.|....   |..|.|.||   .:..|::.|.:   .|:..::........
Human   691 GNLGEEEPKFHAHEENRGHSE---VNFDSSTVVKEPGLKDNMNAERK---SKVGNTYILKASLEP 749

  Fly  2181 AAVAATAAAATSDTPATSP-----SELAS-PKNSLS-AKYRSLVMINKDNESAAGDYEMANSSSN 2238
            ..:.:|...|.:.:|...|     .|... |||.:. .||:.:     .:..:..:.|.|.    
Human   750 ENIKSTPGVANNGSPWKKPEVQFQQEAGEVPKNQVQREKYKRV-----SDRISFWEGEKAG---- 805

  Fly  2239 FSNIRHKDPTSSNNSHTVGQNFASDSFRAMEPTELVSSDREAYSVDSLNEPPAVPELSVEDGLAD 2303
             :.|.|:.||||.:..       ..|.:|.:|   |...:...|:|||:              .|
Human   806 -AKITHEKPTSSCSQE-------QPSAKAYQP---VKKSQGVSSMDSLS--------------TD 845

  Fly  2304 DDSWVEELSQRGE-DEDEDLSNATTTPTATDSEDAEGEGEGARRHGYMDREEDLR---------- 2357
            ...:.:.:.:|.. |||:..|..:.:.::..|::.:.:..|..|: |:..|:..:          
Human   846 QSEYNQAIPKRVVLDEDDQASQLSNSYSSNKSKETKPQIAGPSRY-YLSAEQSDKVSLFQNKKNE 909

  Fly  2358 GYNRSAI--------DFTL--------------------HTIVEESCEESEVASMRADNEDVELE 2394
            ...||.:        :.||                    ..:|.||....:|.|::      |..
Human   910 PIKRSQVADSLPSRRNITLPALQPPSNVGSERHAPLEKDRPLVRESNANFKVMSLK------ERM 968

  Fly  2395 DEDLSERRRQRTLQHHHRLSASELEKYFFFGLGDGRVMSSIDTRGDDTASEVSSECSESLDSLP- 2458
            ||..:|       |.::......|.|::           .::...:...::.:...:...:|.| 
Human   969 DEPNAE-------QVYNPSQFENLRKFW-----------DLEANSNSKDNDKNITTTSQKNSAPF 1015

  Fly  2459 ------------------HEDQLLDTSGASDLASSRLEKYFLSGFM---------GFSGAEK--- 2493
                              ||.::| .|....:|...:||....|.:         ..|...|   
Human  1016 NRQKHKEFSDIKLSGKNTHEAEVL-LSPKKVMAREEMEKLNSKGILQVLPDEITFPLSPLRKYTY 1079

  Fly  2494 QAESDESG-GSVGSDSEGQPSP--------SQRR------KRLVRARGTPRSHNSSLDNLLLPES 2543
            |...:||. .:|..::||..:|        |::.      |..|.::....:.|.||..||   |
Human  1080 QLPGNESSKENVEKNTEGIVTPVFKEEKDYSEQEIQESIIKTNVLSKDCKDTFNDSLQKLL---S 1141

  Fly  2544 DTLDATVTSAGGAA------------------AATVEDTSESEAG--------CDDTVIHLANAG 2582
            :|....:..:||..                  .....||.|...|        .|.||:|     
Human  1142 ETSTPAIQPSGGKVHGKQVLEPSVSENRTWPQKTDFADTEEEVKGPEKIINEHVDKTVVH----- 1201

  Fly  2583 ASDGSSSDTIKRKKQLRKRHDSLDEKKLHDLEPSECRTPTP----------GSSGQVQMQSQAKK 2637
                   ..:||.....    |||  ||  |:.:...:|:|          |::.:::......|
Human  1202 -------PKVKRNSLTA----SLD--KL--LKEATGTSPSPLQAKLAPVITGTNSKLEEGRFFGK 1251

  Fly  2638 QQQQHHHS-------------RDSGFVGSNDDLLKAAPDCEPPKSPTPALEQISEDREPVHSQIS 2689
            ..:|.|::             ||..|  .|..|||.|...|...|....::..:||..|:..   
Human  1252 GIEQSHNTSADKREILAPFPVRDETF--GNTALLKKAESGECQLSTQNLIQMAAEDSHPLDP--- 1311

  Fly  2690 LARMDQPSTSAAAAVASTLSSQLKNLALPNLVRKDSFNNWSSDEETNLMMSKMRQFFKNLIVATA 2754
                               :|||.        ||.||.:.:|..:..|......      :|..|
Human  1312 -------------------TSQLS--------RKGSFGDVASPPQDMLFPQDAH------LVPQA 1343

  Fly  2755 NAQQSKPSTPNQGPSTTNVNTTPSSQRRLAKSRPAQLAYFENELTRLMKTV-------------- 2805
            ...          ||.|.::.|  .::.:...||..     |:::..::.:              
Human  1344 RVH----------PSQTEISET--VEKVILPPRPVL-----NDVSAALQKLCGEVWLSYPAGREV 1391

  Fly  2806 -PGINDEQVREIVEYLSSE-------DTWS--DSY--DSSDYTSSDL---EGGERKGQLKAQISA 2855
             ||..:.:..|.|:.:.|.       ..|:  |:.  |..|:.||::   :..|....|.||:|.
Human  1392 GPGEVNPEFPEAVQPVCSPLNPPGVISPWATMDTIVPDRKDFYSSNVVPDKTHEVGSYLAAQMSP 1456

  Fly  2856 SCQQIINKFEIDEEGDRGDGGLLDESQSVPMEALVYQKLVASFSKVAAGGE----PETEATKAVE 2916
            |.|.:.:...|..:..:   ||..|.:.:..|.:|..|  :.|.:.:||.|    .|||...:..
Human  1457 SDQTLSSFASIVAQYGK---GLPQEVEEIVRETIVQPK--SEFLEFSAGLEKLLKEETETFPSKY 1516

  Fly  2917 EA---------------EP---STERSPQLFAKVMQHIGTRLVA----------LMHEVSSGNET 2953
            |:               ||   ::|..|:...:.::.....|:.          |:.|::   |.
Human  1517 ESDTGNLSPSKLIGSTEEPRRATSECHPEELKETVEKAEAPLITESAFDAGFEKLLKEIT---EA 1578

  Fly  2954 PTPSPQGQRHHRRLQAKISATTTEDEEDE---------------VAEQLKAMPIKQLKLRSKSH- 3002
            |...|         |..:...|.|.|..:               .|.|...|..|...|.|:.: 
Human  1579 PPYQP---------QVSVREETHEKESSQSEQTRFLGTVPHFYRAASQTSEMKDKSNGLESQVNQ 1634

  Fly  3003 ------------DLLLD--GT--------TPHSHHLHHHATV--------HYPAGGVGSGAGGSG 3037
                        |||:|  |:        ||..:..|...|:        .....||..|.|...
Human  1635 CDKMLGGDALVTDLLVDFCGSRSGVEIPRTPQLYVAHEIGTIKTVTPPEDRDSESGVAGGQGTLQ 1699

  Fly  3038 GPGHSDNAGEECGVTSDYERFSWRGSFESALLANGDSRTRLSQL--------------------S 3082
            .||..: |.|...|:        |......||.|.::.|:.|::                    |
Human  1700 EPGFGE-ASEAISVS--------RNRQPIPLLMNKENSTKTSKVELTLASPYMKQEKEEEKEGFS 1755

  Fly  3083 QLD-RDNSSSASALAVAKRRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAHHHQLESSPAKP 3146
            :.| .|.::|::|             .|....|.|.|:...|..            .||.|.|:.
Human  1756 ESDFSDGNTSSNA-------------ESWRNPSSSEEEPSPVLK------------TLERSAARK 1795

  Fly  3147 WLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPR 3211
            ..|.:...|..||:...:..:.|:.:..:...||                 .|:|...:...:||
Human  1796 MPSKSLEDISSDSSNQAKVDNQPEELVRSAEDDE-----------------KPDQKPVTNECVPR 1843

  Fly  3212 LPTTGVGAPITSTPKTKSQSALNHTPSNLSTVSATGSAKSARYRSPGLAARAAAVSGAGGGSSGG 3276
            :          ||..|:..:..:| |..|..:|.:..|                           
Human  1844 I----------STVPTQPDNPFSH-PDKLKRMSKSVPA--------------------------- 1870

  Fly  3277 VGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMSAEEAKVAAEELSR---SPVIGQRQADGSGSP 3338
                               ||..:.|.|:     .:.|..::.:|||   ||           |.
Human  1871 -------------------FLQDESDDRE-----TDTASESSYQLSRHKKSP-----------SS 1900

  Fly  3339 IQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGVRSESMASVYSGAGEGRYGTVVVKGQVEFA 3403
            :.:.:||                     |.::||...|.|:.||||    |.:|.:.|||.::||
Human  1901 LTNLSSS---------------------SGMTSLSSVSGSVMSVYS----GDFGNLEVKGNIQFA 1940

  Fly  3404 MQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETM 3468
            ::|...|..|.|.|.:||||||.|.|:.|||||||.||||||.|.||:||.|.|.||||:::|.:
Human  1941 IEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEIL 2005

  Fly  3469 RFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQS---QWYLLQERSEPFDEV 3530
            |:......|:::.|.|::||.|.|.||.|||||.::|:...:||.|:   :||.|:.::.|....
Human  2006 RYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALE 2070

  Fly  3531 ATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVK 3595
            |..||::.:.|:|:|                             :.|..|...|:  |::|:.||
Human  2071 AENRGEMKLALQYVP-----------------------------EPVPGKKLPTT--GEVHIWVK 2104

  Fly  3596 EAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALE 3660
            |...| |:......::|.|..:|||.:|.|:|||..|.:|.:|.:|:|.||:....|:|.|..:|
Human  2105 ECLDL-PLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVE 2168

  Fly  3661 LTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRSS 3725
            ||||||.:| :|:|:||:|...|||:|||.:|:|||:|.:|::||:.|::.||.|:|.:|.||..
Human  2169 LTVWDHYKL-TNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRML 2232

  Fly  3726 L 3726
            |
Human  2233 L 2233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btszNP_001247109.1 FYVE_Slp3_4_5 26..73 CDD:277286
Atrophin-1 <299..>500 CDD:460830
C2A_SLP 3398..3520 CDD:176056 62/124 (50%)
C2B_SLP_1-2-3-4 3534..3723 CDD:175987 68/188 (36%)
SYTL2NP_996810.2 PHD_SF 5..>41 CDD:473978 9/35 (26%)
C2 1934..2061 CDD:472691 63/126 (50%)
C2B_SLP_1-2-3-4 2074..2230 CDD:175987 68/188 (36%)
Blue background indicates that the domain is not in the aligned region.

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