DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btsz and SYT17

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_011544168.1	Gene:	SYT17 / 51760	HGNCID:	24119	Length:	481	Species:	Homo sapiens

Alignment Length:	431	Identity:	111/431 - (25%)
Similarity:	175/431 - (40%)	Gaps:	100/431 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3315 KVAAEELSR--SPVIGQRQAD-----GSGSPIQSRASSETWPTQSDEDIDR-----LVAMHQNRS 3367
            ::::.|..|  ||:|..:..:     ....|||......|:   :.:|..|     |.::..|..
Human   115 RISSLESRRPSSPLIDIKPIEFGVLSAKKEPIQPSVLRRTY---NPDDYFRKFEPHLYSLDSNSD 176

  Fly  3368 SLSSLGVRSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDL---AAVDAK 3429
            .:.||  ..|.:.|.|.            .|.:.|:.||:...:.|.|.|:..:||   .:.|..
Human   177 DVDSL--TDEEILSKYQ------------LGMLHFSTQYDLLHNHLTVRVIEARDLPPPISHDGS 227

  Fly  3430 RN---RSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDM 3491
            |.   .|:||||:.||||:..:  ::|.||:.|..|:|:|...|..|....:.|||.|||...|.
Human   228 RQDMAHSNPYVKICLLPDQKNS--KQTGVKRKTQKPVFEERYTFEIPFLEAQRRTLLLTVVDFDK 290

  Fly  3492 FGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSR 3556
            |.|:..:|:|||.|...........|..|...|:  :||..  |::::.|.|:|
Human   291 FSRHCVIGKVSVPLCEVDLVKGGHWWKALIPSSQ--NEVEL--GELLLSLNYLP----------- 340

  Fly  3557 GSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDR 3621
                                         ..|:|:|.|..||.|.....:...|.|.|..|:...
Human   341 -----------------------------SAGRLNVDVIRAKQLLQTDVSQGSDPFVKIQLVHGL 376

  Fly  3622 TRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGI---RFSLG 3683
            .....:||..::.|:.|.:|.:|.:: |..|||...:|..||:.|:..:||:|:|.|   ::|.|
Human   377 KLVKTKKTSFLRGTIDPFYNESFSFK-VPQEELENASLVFTVFGHNMKSSNDFIGRIVIGQYSSG 440

  Fly  3684 TGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRS 3724
            .               .|.:.|:.||:.....||....|||
Human   441 P---------------SETNHWRRMLNTHRTAVEQWHSLRS 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	44/127 (35%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	42/191 (22%)
SYT17	XP_011544168.1	C2A_Synaptotagmin-15-17	193..321	CDD:176036	45/129 (35%)
SYT17	XP_011544168.1	C2B_Synaptotagmin-17	330..464	CDD:176055	42/189 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920