Protein Alignment btsz and sytl2

DIOPT Version :10

• Sequence 1: NP_001247109.1
• Gene: btsz / 3346167
• FlyBaseID: FBgn0266756
• Length: 3734
• Species: Drosophila melanogaster
• Sequence 2: XP_012812257.2
• Gene: sytl2 / 493264
• XenbaseID: XB-GENE-945155
• Length: 2036
• Species: Xenopus tropicalis
• Alignment Length: 2447
• Identity: 499/2447 - (20%)
• Similarity: 850/2447 - (34%)
• Gaps: 784/2447 - (32%)

  Fly  1482 VASKYQSRNLCETQSAATTQTYLASKNSHEEV---EAADETNIHKNQVPAAAAAATAQIQTATRA 1543
            |:...|.||...:.:.....|.| .|::||.|   |:.|:.: :.:.:|       .:|:...:.
 Frog   160 VSPSRQRRNPFNSTNEGDDDTEL-GKDTHEPVNGPESGDKVS-YPDVLP-------PKIKFGVKL 215

  Fly  1544 --AAPAVITRFGGLAVENAVGNVAESASASAASPIPKPKPRAQHPEQIDRHRATAETAKNLSSNR 1606
              .||..|.|         :.:.:.:||.:....||.||||            |....|..|..|
 Frog   216 PYPAPGEIIR---------LSSTSPNASLTNGGQIPIPKPR------------TMPLKKTDSLER 259

  Fly  1607 LIENIKMSD----EASPSTAAHLQSESYAASSPDEASSNSSQDGD-------------------Q 1648
            ...::|..|    ...|.:....:|.|   ||.|..|...:|..|                   .
 Frog   260 SSSDLKREDSFGSSGRPKSILKRRSSS---SSTDSESIRLAQKADLNKIGLSTPILQAEPVDESP 321

  Fly  1649 DRERELEEQAEQKPRRTTQRSYNVAGMMEEQQLGEVDAVEQRHHSTTSDSSSSSSSNSSSSSESC 1713
            |:.:::...|.......:....:|.|    :::||...:|       ...|.:|..|.:||.:|.
 Frog   322 DKLKQVRFSANVHQNPPSPGGESVGG----KEIGEFGILE-------PGLSQASLENRASSEDSV 375

  Fly  1714 DS--DDTGTVRDRRPKRRRFNKVFVVNRQPGGRV--RRSSSTEGDSLSSSEANLED-----SSDN 1769
            .:  ..:..|.|...|        .:.|:..|.:  ...|..||.||.::.|:|.:     ..|:
 Frog   376 SAPKPSSSLVLDILTK--------TIYRKGSGEIPDLNGSPVEGPSLGANSASLNEDLNNIKEDS 432

  Fly  1770 DTDTERTDCGIVLNYVKPLEEEPKKAEEEPPTAARDCQSSDEDNIND--------------DESE 1820
            .....:.:..:.|......:.:|..|..:.|:.:.....|.:.::.|              |...
 Frog   433 FVQENKPEVSLALEANVSSDNDPLYAAVKKPSGSFSSGLSQDYDMEDAHKFLGQGWKMQNRDRGG 497

  Fly  1821 RRVANSTDELANCIVVVGG------QTDDAAAGVVLHHMRSLPDVE--FDGEQSERRQAHEIDAS 1877
            :::...|..        ||      :.||         :.::|.:|  ...|:::..:...:||.
 Frog   498 QKLVFGTSS--------GGIGKMSFERDD---------LSNIPQLENVLSFEENKENEGDYLDAE 545

  Fly  1878 DALAACDELHSISNDVNRLLALHKQNSQLELKLQRLRQGVAEINEDLQLSTTGTDVAAT-HCTTQ 1941
            :......|........:...|..:.:..:.   :.|||.:...|    ||...||...| |
 Frog   546 ENDMPDMESEPADEPTDYFPAWRRPSIIIN---ESLRQPITADN----LSKERTDAPQTGH---- 599

  Fly  1942 PGSAGKPDECNSPSSRKSPSTVLSSNDVGPLSLTCLRQVEAVVEVEANRADGKLRDERNGRTAEQ 2006
             |...:|    |..|.....:..||.|               ::||:......:||.:  |..|.
 Frog   600 -GKFRQP----SQESGIQTDSAYSSED---------------LKVESRYTPLSIRDAQ--RVEED 642

  Fly  2007 TEERVVTCSQACKINDNSDYSLDSLSATSASLLAPEQQQQQPLQQVEESARLPADAR------EQ 2065
            ..:.::|       |..|:...:::..|:      ::...:.|.|..|...||..::      ..
 Frog   643 KPDGLMT-------NLYSESKPNAVEGTA------DKANVRFLDQGVEGTGLPIPSKFETMYFRD 694

  Fly  2066 RYRRGAKSE---SAESPV------ENEMLNVAVASRAALLGS--NNNNTHRNDNSNNENTNNNDG 2119
            |:..|.|.:   ||:.|:      .|..||..|.|...|..:  :....|.:....:.:..:.:.
 Frog   695 RFSDGPKEQMLNSAQRPIWNTEEKNNLKLNADVPSSTLLKDTLYSKKPLHVDPQLKSSSEISPES 759

  Fly  2120 ELGHNNNDAFAAQKTRNSGSSVVVGCDISDVVSVNSNVSGENECDF--DKIFGSHQQNTPSASAA 2182
            .|..||.:..:.::..:.        .::..::...::.||.:.|.  :.::...||..|:....
 Frog   760 LLPQNNYEILSEEELTSQ--------KVASWLAQTPSIQGEEQIDLIEEHLYPEEQQMYPAEEQI 816

  Fly  2183 VAATAAAATSD--------TPATSPSELASPKNSLSAKYRSLVMINKDNESAAGDYEMANSSSNF 2239
            .|.......|:        :.....|.....||:|              |....:...|...:..
 Frog   817 YAKEEQVNQSEEVGEVVERSTVNHKSGAEEFKNAL--------------EKLKEEMSQAPPIAEM 867

  Fly  2240 SNIRHKDPT------SSNNSHTVGQNFASDSFRAMEPTELVSSDREAY------SVDSLNEPPAV 2292
            .|:.::.|.      .:::..|....:|.|..:...||...|....::      ...|:|:..:.
 Frog   868 QNVSYEQPNRGSVVIEADSKATEPFPYAVDKNQDRAPTAYRSLPNSSFFQRVMQISQSINKEASP 932

  Fly  2293 PELSVED----GLADDDSWVEELSQRGEDEDEDLSNATTTPTATDSEDAEGEGEGARRHGYMDRE 2353
            .|:.:.|    .|.:..:....|.|     :|.:::.|..|....::.|.
 Frog   933 DEVQMTDQQKSPLPEPINLTNNLKQ-----EEVINDLTPLPMKAQTDYAS--------------- 977

  Fly  2354 EDLRGYNRSAIDFTLHTIVEESCEESEVASMRADNEDVELEDEDLSERRRQRTLQHHHRLSASEL 2418
                .|:::.::              |:.|:  |:::|. |:|.:.|  :...::...|:|..:|
 Frog   978 ----PYDKNDVE--------------EIRSL--DSQEVR-EEEVVQE--KVTAVKDAFRISLQKL 1019

  Fly  2419 EKYFFFGLGDGRVMSSIDTRGDDTASEVSSECSESLDSLPHEDQLLDTSGASDLASSRLEKYFLS 2483
            |:.:...|                |||.
 Frog  1020 EEEYNIAL----------------ASEA------------------------------------- 1031

  Fly  2484 GFMGFSGAEKQAESDESGGSVGSDSEGQPSPSQRRKRLVRARGTPRSHNSSLDNLLLPESDTLDA 2548
                     :...|.|.||..|...| .|||:..:.                      |.:.:..
 Frog  1032 ---------QMTPSFEEGGEEGQVQE-SPSPTVEQS----------------------EEEVVPE 1064

  Fly  2549 TVTSAGGAAAATVEDTSE--SEAGCDDTVIHLANAGASDG-----SSSDTIKRKKQLRKRHDSLD 2606
            .|.....|....:|..||  :.|...|..|.|::...::|     |.|.|:::.::
 Frog  1065 KVPVVKDAFKVALERLSEEHNSAMASDAQITLSSGEVNEGYLFQESPSPTVEQSEE--------- 1120

  Fly  2607 EKKLHDLEPSECRTPTPGSSGQVQMQSQAKKQQQQHHHS---RDSGFVGSNDD--LLKAAPDCEP 2666
                 ::.|.  :.|....:.:|.::..|     :.|:|   .|:..:.|.|:  ||:
 Frog  1121 -----EVVPE--KVPVVKDAFKVALERLA-----EEHNSAMASDAQIIPSFDEGYLLQ------- 1166

  Fly  2667 PKSPTPALEQISE----DREPVHS---QISLARMDQPSTSAAAAVASTLSS--------QLKNLA 2716
             :||:||:||..|    ::.||..   :::|.|:.:...||.|:.|....|        ||:..:
 Frog  1167 -ESPSPAIEQSEEEVVPEKVPVVKDAFKVALERLVEEHNSAMASDAQITPSSEEVNEGHQLQECS 1230

  Fly  2717 LPNLVRKDSFNNWSSDEETNLMMSKMRQFFKNLIVATANAQQSKPSTPNQGPSTTNVNTTPSSQR 2781
            .|.:.:...:.|  ..||....||...:.:::...|..|..|.:.|.|   ..||.:
 Frog  1231 SPTIDQSKEYAN--EVEEVVEKMSVPDKSYQDEFTAALNKLQVEASEP---AYTTEI-------- 1282

  Fly  2782 RLAKSRPAQLAY-FENELTRLMKTVPGINDEQVREIVEYLSSEDTWSDSYDSSDYTSSDLEGGER 2845
                |.||.... |..|::            .|.|                            .|
 Frog  1283 ----SEPANAHIDFNTEIS------------SVHE----------------------------NR 1303

  Fly  2846 KGQLKAQISASCQQIINKFEIDEEGDRGDGGLLDESQSVPMEALVYQKLVASFSKVAAGGEPETE 2910
            ..::|..:|:..                       |||:|.|.:                  |..
 Frog  1304 PDEVKTNLSSPV-----------------------SQSIPYETV------------------ENT 1327

  Fly  2911 ATKAVEEAEPSTERSPQLFAKVMQHIGT-RLVALMHEVSSGNETPTPSPQGQRHHRRLQAKISAT 2974
            ..:.....:...||         .|.|. |::.|...:|.|||....:|:..|:.|:..
 Frog  1328 NVRLTSPDKGRVER---------PHSGNFRVMTLKERISDGNEEQISNPEQFRNLRKFW------ 1377

  Fly  2975 TTEDEEDEVAEQLKAMPIKQLKLRSKSHDLLLDGTTPHSHHLHHHATVHYPAGGVGSGAGGSGGP 3039
               |.|...:::|..  ..:|..:.|:.|.|.|..
 Frog  1378 ---DTEKRSSKELDG--YSKLNAQLKTKDNLKDNL------------------------------ 1407

  Fly  3040 GHSDNAGEECGVTSDYERFSWRGSFESALLANGDSRTRLSQLSQLDRD-----NSSSASALAVAK 3099
              ||.:..:...|                         |:.|.:.|.:     :|..:|::..|.
 Frog  1408 --SDTSSTKTAST-------------------------LNDLQERDENVYKDISSRESSSVDGAS 1445

  Fly  3100 RRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAHHH-QLESSPAKPWLSSAGSSIGGDSTKDV 3163
            ....||:: .:...||                 |.|.| ..|...|:.|           :.::.
 Frog  1446 AAVIGDII-GKDAASL-----------------DLHQHTDEEEIGAREW-----------NWEEP 1481

  Fly  3164 RRSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTK 3228
            .....|..|....|.|...|.:......:||...:      ..|:|.||           |...:
 Frog  1482 ESQDNPTFISNMPSRDVVISKKVYSTIESLPSYKD------KENNLDRL-----------TEPQE 1529

  Fly  3229 SQSALNHTPSNLSTVSATGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAG 3293
            ..|.....|.:|..        :|||.          |.....||.....|..|||:
 Frog  1530 QGSTTQRKPQDLYF--------AARYE----------VLDKNSGSDQSGSVTESSGN-------- 1568

  Fly  3294 FQFLYSK-----RDARKR--------------------------------------------LNM 3309
              .||.|     .||.||                                            :.:
 Frog  1569 --LLYKKPESESPDASKRNSIDPKQGIEESDPILRALKRSSTKTLPPLPVQEVSLEKSNQDDITV 1631

  Fly  3310 SAEEAKVAAEELSRSPVIGQRQADGSGSPIQSRASSETWPTQSDEDID------------RLVAM 3362
            ..|:.....||:....|:.:|  .....|.:.:..|::.|:..::|.|            :|...
 Frog  1632 PKEDRDHTYEEVRADKVVPER--SHFSDPEKLKRLSQSVPSFLNDDTDGRETDSASESSFQLGRH 1694

  Fly  3363 HQNRSSLSSLGVRSESMASVYSGAG------EGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCK 3421
            .::.|||::|. .|..|||:.|.:|      .|.:|.|.:||.::||:.|...|...:|.|.:||
 Frog  1695 KKSPSSLTNLS-GSSGMASLSSVSGSVMSIYSGDFGNVDIKGNIQFALDYADNLQEFQVFVSQCK 1758

  Fly  3422 DLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTV 3486
            ||||.|.|:.|||||||.||||:|:|.|||||.|||.||||::::.:|:....::|.|:||.|:|
 Frog  1759 DLAAADVKKQRSDPYVKAYLLPEKAKMGKRKTGVKKKTLNPVYNDVLRYKISKNALLSQTLNLSV 1823

  Fly  3487 WHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKS 3551
            ||.|:.|||.|||||.|||....:.|.|..||.||.|:.........||::.:.|||:|
 Frog  1824 WHHDVLGRNSFLGEVDVNLASWDWSNKQMNWYPLQPRTPAAGIGLENRGEMKLALKYVP------ 1882

  Fly  3552 SFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSY 3616
                  .:.||:     |..|:              |::|:.:||..:|..::.| ..::|.|..
 Frog  1883 ------EAFTGA-----KNAGT--------------GEVHIWLKECTNLPMLRGN-KINSFIKCT 1921

  Fly  3617 LLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFS 3681
            :|||.:|.|:|||..|.:|.:|.:|:|.||:....|:|.|..:|||||||::| :|.|:||:|..
 Frog  1922 ILPDTSRKSRQKTRAVDKTPNPYFNHTMVYDGFRKEDLKEACVELTVWDHNKL-TNHFLGGLRIG 1985

  Fly  3682 LGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLR 3723
            ||||:|||..|:|||:...|.:.|:.|:..|:.|||..|.||
 Frog  1986 LGTGKSYGTPVDWMDSNAAEATTWEKMITSPDTWVEAILPLR 2027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		Atrophin-1	<299..>500	CDD:460830
		C2A_SLP	3398..3520	CDD:176056	65/121 (54%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	68/188 (36%)
sytl2	XP_012812257.2	PHD_SF	5..>44	CDD:473978
		C2A_SLP-1_2	1734..1858	CDD:176039	66/123 (54%)
		C2B_SLP_1-2-3-4	1871..2027	CDD:175987	68/188 (36%)