DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and Syt4

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_477464.1	Gene:	Syt4 / 40876	FlyBaseID:	FBgn0028400	Length:	474	Species:	Drosophila melanogaster

Alignment Length:	450	Identity:	112/450 - (24%)
Similarity:	183/450 - (40%)	Gaps:	124/450 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly  3322 SRSPVIGQRQADGSGSPIQSRASSE------------TWPTQSDED--------IDRLVAMHQNR 3366
            |.||..|::.  |..||:|.:::|.            ..|.|..|.        :|.....|...
  Fly    78 SPSPTGGKQM--GLLSPMQDQSTSPIAQPNVKYSEEGDGPAQHAEQQNGNQLTVVDGNGLKHSLH 140

  Fly  3367 SSLSSLGVRSESMASVYSGAGE------------GRYGTVVVKGQVEFAMQYNYKLSALEVHVVR 3419
            :||....|.:.:..||.....:            .:||.:   |.:.|.::|..:.:||.|.::|
  Fly   141 NSLHHSPVETIANGSVTITLDDHSLTNGKELTVTDQYGKL---GTIYFKLRYLAERNALMVSIIR 202

  Fly  3420 CKDLAAVDAK--------------RNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRF 3470
            |:.|......              :..:|||||:.|||||..  |.||:|.::|.||::||...|
  Fly   203 CRGLPCKGGSSGTGDIPTGMNGRTQAATDPYVKLQLLPDKQH--KVKTRVVRNTRNPVYDEDFTF 265

  Fly  3471 H-TPISSLESRTLWLTVWHSDMFGRNDFLGEV-----SVNLQGRLFDNPQSQWYLLQERSEPFDE 3529
            : ..::.|::.:|...:...|.:.|:|.:|||     |:.: |.:.....|....:|.||....
  Fly   266 YGLNMNDLQNMSLHFVILSFDRYSRDDVIGEVVCPLTSIEI-GDISKEALSISKEIQPRSLKIR- 328

  Fly  3530 VATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLV 3594
             |..||::::.|.:.|                                        ..|:|.|::
  Fly   329 -AQGRGELLISLCWQP----------------------------------------AAGRLTVVL 352

  Fly  3595 KEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYE-------DVSLE 3652
            .:|::|..:...|..|.:.|.|||.:..|.:|:||.|.||||.|.:|.:|.::       ..|||
  Fly   353 LKARNLPRMDVTGLADPYVKIYLLYNGQRIAKKKTHVKKRTLSPVFNESFAFDIPAAEGAGASLE 417

  Fly  3653 ELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRP 3712
            .:|   |||.:.|.||:..||.:|  |..||...|          :...|:.|..:.:.|
  Fly   418 GVS---LELMLLDWDRVTKNEVIG--RLELGGPNS----------SSTALNHWNEVCNSP 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	40/141 (28%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	46/185 (25%)
Syt4	NP_477464.1	C2A_Synaptotagmin-4-11	179..322	CDD:176034	40/148 (27%)
Syt4	NP_477464.1	C2B_Synaptotagmin-4	332..473	CDD:176049	46/185 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1065
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.920