DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and Sytbeta

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_648734.1	Gene:	Sytbeta / 39630	FlyBaseID:	FBgn0261090	Length:	602	Species:	Drosophila melanogaster

Alignment Length:	805	Identity:	163/805 - (20%)
Similarity:	269/805 - (33%)	Gaps:	279/805 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly  2885 PMEALVYQKLVASFSKVAAGGEPETEATKAVEEAEPSTERSPQLFAKVMQHIGTRLVALMH--EV 2947
            |....:..|.:.|:|::|   :....|.:.|.....|.:......:......|...|:::|  .:
  Fly     6 PAACWLAHKRIESWSRMA---KERVGAVRRVTLDRNSADEGTPSGSGASSTAGGNGVSVVHILPI 67

  Fly  2948 SSGNETPTPSPQGQRHHRRLQAKISATTTEDEEDEVAEQLKAMPIKQLKLRSKSHDLLLDGTTPH 3012
            ..|:.||.|.|.                                                 |.|.
  Fly    68 GEGSTTPPPQPM-------------------------------------------------TPPP 83

  Fly  3013 SHHLHHHATVHYPAGGVGSGAGGSGGPGHSDNAGEECGVTSDYERFSWRGSFESALLANGDSRTR 3077
            |     .::|.....|:||.:.||        ..:.|.:.:|.|        |.|:.........
  Fly    84 S-----ASSVTSTTSGIGSVSAGS--------VSDSCDLPTDSE--------EVAIAKECQPIQP 127

  Fly  3078 LSQLSQLDRDNSSSASALAVAKRRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAH-HHQLES 3141
            .|||..:                 ..|..|...|..::|....|.:|....:.....| |||..|
  Fly   128 ASQLHGM-----------------HGGMGLNHHHMGTVSATGTDILRGPAEVFHSPLHLHHQSRS 175

  Fly  3142 SPAK----PWLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDEAASHQFGGARSTLP--RSLNPN 3200
            .|.:    |.:||                         .||.::|..:..|.|.:.|  |:..|:
  Fly   176 FPPRLQRTPSISS-------------------------QSSVDSAPSRHSGHRGSSPQIRTFGPD 215

  Fly  3201 QVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTPSNLSTVS---ATGS-AKSA-----RYRS 3256
                ..:|||..|    |.|          ..|..:||.:.|:|   ..|| |.||     |..|
  Fly   216 ----GRSSLPSEP----GFP----------HHLARSPSPMRTISLDARCGSPAHSADPGDLRTPS 262

  Fly  3257 PGLAARAAAVSGAG-GGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMSAEEAKVAAEE 3320
            |..::.|:...|:| ||||.|.||            ||.:.|
  Fly   263 PSQSSLASLAGGSGMGGSSAGKGV------------AGGRCL----------------------- 292

  Fly  3321 LSRSPVIGQRQADGSGSPIQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGVRSESM-----A 3380
               ||::                    .|.:|...:|..:      ...|.||.....:     .
  Fly   293 ---SPLL--------------------IPPRSQPGVDPAM------GPASPLGALQPDLYRMPDG 328

  Fly  3381 SVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDK 3445
            .||..|.|..:..    |::...::|:|.|..|.||::...:|:.::....| ||||::.|.|:.
  Fly   329 PVYLTAPESSHAV----GRLHLRVKYDYHLFDLTVHLIEAHNLSPIEEGGFR-DPYVRLMLQPEV 388

  Fly  3446 SKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLF 3510
            . :.||:|.:.:...||.||:..:|......|:.:.|.|.|...|.:..||.:|||.:::.|...
  Fly   389 D-SRKRQTHIHRGESNPYFDQHFKFPVSRDQLQGKELILQVLDYDRYSHNDIIGEVRISVDGLDL 452

  Fly  3511 DNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIK 3575
            ......|..|....:|.::    |.:::..|.|:|
  Fly   453 SKSVEIWGDLLRTKKPKED----RPELLCSLNYLP------------------------------ 483

  Fly  3576 SVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKR--TLHP 3638
                ::||      |.|::.:|::|..::     :.:.|.||:.:..|..|:||.:.|.  ..:|
  Fly   484 ----QAER------LTVVIMKARNLDTLQ-----EPYVKIYLIQNGKRIKKKKTSITKSDDPTNP 533

  Fly  3639 SWNYTFVYEDVSLEELSERALELTV 3663
            .||..|.: ::....|...|:|:.|
  Fly   534 IWNEAFTF-NLQSNYLHNAAIEIYV 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	35/121 (29%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	26/132 (20%)
Sytbeta	NP_648734.1	C2	341..463	CDD:301316	35/127 (28%)
Sytbeta	NP_648734.1	C2B_Synaptotagmin	473..601	CDD:175975	25/131 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.920