DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and Sytl5

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_848016.1	Gene:	Sytl5 / 302538	RGDID:	631342	Length:	753	Species:	Rattus norvegicus

Alignment Length:	687	Identity:	206/687 - (29%)
Similarity:	323/687 - (47%)	Gaps:	135/687 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  3073 DSRTRLSQLSQLDRDNSSSASALAVAKRRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAHHH 3137
            |....||.:.|....:........::|.|||            :|.::...::    ..|.::..
  Rat   164 DKSDTLSSVRQKATHDGPKRKGFLLSKFRSA------------TRGEIKTPKA----ESGRSYSL 212

  Fly  3138 QLESSPAKPWLSSAGSSIGGDSTKDVRRSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQV 3202
            .|::...:.:.|.:||..|..::.|:              :|:.|..   ||
  Rat   213 DLDNQNLQSFKSVSGSDRGSTTSSDL--------------TDQEAGR---GA------------- 247

  Fly  3203 VASTNSLPRLPTTGVGAPITS---TPKTKSQSALN---HTPSN---LSTVSATGSAKSARYRSPG 3258
                   |:...:..|.|:|.   .|..:|.::::   |...|   |:|:.:.....:..:|...
  Rat   248 -------PKGSCSNGGIPVTQRSPAPSARSVTSISSREHGFENSMALATIESISEELTKSHRRNT 305

  Fly  3259 LAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKRLNMSAEEAKVAAEELSR 3323
            ....:.||||..                          |.|:| :|..|::|    :..||:|..
  Rat   306 SGTPSIAVSGTS--------------------------LSSER-SRSELDLS----ESFAEDLED 339

  Fly  3324 SPVIGQRQADGSGSP--------------IQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLGV 3374
            :..|..|...|:...              :.||.|:.|....|...........:.||.|.....
  Rat   340 TSSIRSRSVPGALDKDLNSLEDTEDGVDLVSSRFSANTHSLASGLSTSSQAGSDRKRSYLHVPDA 404

  Fly  3375 RSE-----SMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSD 3434
            .|:     ||.||||..|:  ||.|.|.|::...:.|.||...|.:.|..|::||..|.|:.|:|
  Rat   405 DSDTTSLNSMMSVYSETGD--YGNVKVTGEILLHISYCYKTGGLYIFVKNCRNLAIGDEKKQRTD 467

  Fly  3435 PYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLG 3499
            .|||.||||||::..|||||::..| ||.|:||:::....:.||:|||.|:|||.|.||||.|||
  Rat   468 AYVKSYLLPDKTRNNKRKTKIRTGT-NPEFNETLKYTISHTQLETRTLQLSVWHYDRFGRNSFLG 531

  Fly  3500 EVSVNLQGRLFDNPQSQWYLLQERSEPFDEVA-TYRGDIVVGLKYIPPENIKSSFF----SRGSS 3559
            ||.:......|:||..:|::||.:.|...::: .|:|::.:.|:|||||  ::..|    .:|..
  Rat   532 EVEIAFDSWNFENPCDEWFVLQPKVELAPDISLQYKGELTIVLRYIPPE--ENLIFPVEQPQGKK 594

  Fly  3560 ITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRS 3624
            |             .|....|......||.|.|.:||||:|:.:||.||.|:|.|.|||||..::
  Rat   595 I-------------FKKGKKKESPAISGGILEVFIKEAKNLTAVKAGGTSDSFVKGYLLPDDNKA 646

  Fly  3625 SKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYG 3689
            :|.||.|||::::|.||:.|::..:..:::....||||:||.:..:||.|:||:|.:.|:|.|:|
  Rat   647 TKHKTAVVKKSVNPQWNHVFIFSGLYPQDIQNACLELTIWDKEAFSSNIFLGGVRLNSGSGISHG 711

  Fly  3690 RQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRSSL 3726
            :.|:|||:.|:|..|||.|.|.|...|||.|:||||:
  Rat   712 KAVDWMDSRGEEQRLWQKMADNPGTSVEGVLMLRSSM 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	56/121 (46%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	75/192 (39%)
Sytl5	NP_848016.1	FYVE_Slp5	62..108	CDD:277305
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..188		4/23 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	221..283		16/98 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	298..359		17/91 (19%)
		C2A_SLP-4_5	430..553	CDD:175995	56/123 (46%)
		C2B_SLP_1-2-3-4	567..745	CDD:175987	75/192 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I4929
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004380
OrthoInspector	1	1.000	-	-		otm46303
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45716
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010