DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and Sytl1

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_006239075.1	Gene:	Sytl1 / 297872	RGDID:	1310715	Length:	562	Species:	Rattus norvegicus

Alignment Length:	700	Identity:	219/700 - (31%)
Similarity:	308/700 - (44%)	Gaps:	196/700 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  3074 SRTRLSQLSQLDRDNSSSASALAVAKRRSAGDLLF-SQHQQSLSREQLDRVRSCGSIGGGDAHHH 3137
            |:.||..|..|...:.....|..:.      ||.| ::.:|....:.|.|          |||..
  Rat     8 SQERLRALPSLPMAHGPGPEAEGLL------DLSFLTEEEQEAISDVLKR----------DAHLR 56

  Fly  3138 QLE--------SSPAKP---------WLSSAGSS------IGGDSTK-DVRR--SSVPDAIYETD 3176
            |||        :|.|.|         |...|.|.      .|.|..: .:||  ||..|....:|
  Rat    57 QLEEGRVSKLRASLADPWQLKILTGDWFQEARSQRHHHAHFGSDLVRASIRRKKSSKGDQALGSD 121

  Fly  3177 SSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTPSNLS 3241
            ...|||...                  ....:.||: :..|.||.|   .|::|.....:|..|:
  Rat   122 GDGEAAGED------------------TIEEAEPRV-SIKVAAPET---HTETQEPDFSSPYVLT 164

  Fly  3242 TVSATGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFLYSKRDARKR 3306
            .||:. ..:.....:||               .|||.|.
  Rat   165 KVSSQ-EEEPQDQEAPG---------------QGGVQVA-------------------------- 187

  Fly  3307 LNMSAEEAKVAAEELSRSPVIGQRQADGSGSPIQSRASSETWPT-----------QSDED----- 3355
                                    :||....| :..|..|:|||           ::.|:
  Rat   188 ------------------------EADPELDP-EQEAEQESWPTPAQIKTTSKVLENGEETPGLG 227

  Fly  3356 --IDRLVAMHQNRSSLSSLGVRSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVV 3418
              :||:::...:.|||:|    |....|:.|.:||...|.|.|:|.|.|:::|......|.|.|:
  Rat   228 PSLDRMLSSSSSVSSLNS----STLSGSLKSLSGEAEAGPVQVRGSVLFSLRYEPGTGELRVQVI 288

  Fly  3419 RCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLW 3483
            :|:.|||  |:|.|||||||.||||||.  .||||.|||..|||||:||:|.....:.|..|.|.
  Rat   289 QCQGLAA--ARRRRSDPYVKSYLLPDKQ--NKRKTSVKKRNLNPIFNETLRHSVQQADLPGRVLS 349

  Fly  3484 LTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQER--SEPFDEVATYRGDIVVGLKYIPP 3546
            |:|||.:..|||.|||||.|.|....:|: ::.|..||.|  :.| ||:.: ||.:.:.|||||
  Rat   350 LSVWHRESLGRNIFLGEVEVPLDTWNWDS-EATWLPLQPRIPTSP-DELPS-RGLLSLSLKYIP- 410

  Fly  3547 ENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDA 3611
                          .||..     ||...|           |:||..:|||:.|.|::. |:.|.
  Rat   411 --------------AGSEG-----GGQPPS-----------GELHFWIKEAQGLVPLRP-GSLDT 444

  Fly  3612 FCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVG 3676
            :.:..:|||.:|:|:|:|.||:|:|.|.:|:|.||:.....:|.:...||::|||..|||.: :|
  Rat   445 YIQCSVLPDDSRASRQRTRVVRRSLSPVFNHTMVYDGFGPADLRQACAELSLWDHGALASRQ-LG 508

  Fly  3677 GIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRSSL 3726
            |.|.|||||.|||.||.|||:|.:|..|||.:|::|..||:|.|.||::|
  Rat   509 GTRLSLGTGSSYGLQVPWMDSTPEEKQLWQTLLEQPCEWVDGLLPLRTNL 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	60/121 (50%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	74/188 (39%)
Sytl1	XP_006239075.1	PHD_SF	35..>70	CDD:419867	10/44 (23%)
		C2	267..386	CDD:417471	60/123 (49%)
		C2B_SLP_1-2-3-4	399..555	CDD:175987	74/188 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR45716
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010