DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btsz and Syt17

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_620204.1	Gene:	Syt17 / 192189	RGDID:	708576	Length:	474	Species:	Rattus norvegicus

Alignment Length:	451	Identity:	113/451 - (25%)
Similarity:	179/451 - (39%)	Gaps:	109/451 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  3302 DARKRLNMSAEEAKVAAEELSR-----------SPVIGQRQAD-----GSGSPIQSRASSETWPT 3350
            |.|:    |:.:...:...|:|           ||:|..:..:     ....|||......|: |
  Rat    90 DGRR----SSSDTSKSTYSLTRRISSLDSRRPSSPLIDIKPIEFGVLSAKKEPIQPSVLRRTY-T 149

  Fly  3351 QSD---EDIDRLVAMHQNRSSLSSLGVRSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSA 3412
            ..|   :...||.::..|...:.||  ..|.:.|.|.            .|.:.|:.||:...:.
  Rat   150 PDDYFRKFEPRLYSLDSNLDDVDSL--TDEEIMSKYQ------------LGMLHFSTQYDLLHNH 200

  Fly  3413 LEVHVVRCKDL---AAVDAKRN---RSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFH 3471
            |.|.|:..:||   .:.|..|.   .|:||||:.||||:..:  ::|.||:.|..|:|:|...|.
  Rat   201 LTVRVIEARDLPPPISHDGSRQDMAHSNPYVKICLLPDQKNS--KQTGVKRKTQKPVFEERYTFE 263

  Fly  3472 TPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEPFDEVATYRGD 3536
            .|....:.|||.|||...|.|.|:..:|:|:|.|...........|..|...|:  :||..  |:
  Rat   264 IPFLEAQRRTLLLTVVDFDKFSRHCVIGKVAVPLCEVDLVKGGHWWKALIPSSQ--NEVEL--GE 324

  Fly  3537 IVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLS 3601
            :::.|.|:|                                        ..|:|:|.:..||.|.
  Rat   325 LLLSLNYLP----------------------------------------SAGRLNVDIIRAKQLL 349

  Fly  3602 PIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDH 3666
            ....:...|.|.|..|:........:||..::.|:.|.:|.:|.:: |..|||...:|..||:.|
  Rat   350 QTDVSQGSDPFVKIQLVHGLKLVKTKKTSFLRGTIDPFYNESFSFK-VPQEELENASLVFTVFGH 413

  Fly  3667 DRLASNEFVGGI---RFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGSLVLRS 3724
            :..:||:|:|.|   ::|.|...|               :.|:.||:.....||....|||
  Rat   414 NMKSSNDFIGRIVIGQYSSGPSES---------------NHWRRMLNTHRTAVEQWHSLRS 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	43/127 (34%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	41/191 (21%)
Syt17	NP_620204.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..117		5/30 (17%)
		C2A_Synaptotagmin-15-17	186..314	CDD:176036	44/129 (34%)
		C2B_Synaptotagmin-17	323..457	CDD:176055	41/189 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920