DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and syt8

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	NP_001352218.1	Gene:	syt8 / 103909874	ZFINID:	ZDB-GENE-060303-4	Length:	397	Species:	Danio rerio

Alignment Length:	365	Identity:	105/365 - (28%)
Similarity:	180/365 - (49%)	Gaps:	79/365 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  3374 VRSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVK 3438
            |:.|:..:.||.:.:.|       |::::::::|...|.|.|.:.....|.|:|: ...||||||
Zfish    91 VQPETEDTEYSSSDQQR-------GKLQYSLEFNASRSELTVGIKEAAALKAMDS-GGTSDPYVK 147

  Fly  3439 VYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSV 3503
            ||:||:|||.  .:|||.:.||||:|:|..::..|...|...||.:.|:..:.|.::|.:||:.:
Zfish   148 VYILPNKSKT--FETKVFRKTLNPVFNENFKYQIPQKELTESTLVMQVYDFNRFSKHDIIGEIRL 210

  Fly  3504 NLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLR 3568
            ||....:::...:|..|.|.|:...|   :.|:|...|:|:|..:
Zfish   211 NLSTVDWNHVIEEWRDLSEASKHEQE---HLGEICFSLRYVPTSS-------------------- 252

  Fly  3569 KFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVK 3633
                                :|.|::.|||:|..:...|:.|.:.|..|:.::.:..|:||.|.|
Zfish   253 --------------------KLTVIILEAKNLKKMDQVGSSDPYVKVQLILEKKKWKKKKTSVKK 297

  Fly  3634 RTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDAT 3698
            |||:|.:|.:|.: |||.|::.:..|.::|||||:::.|:.:|  :..||           .|||
Zfish   298 RTLNPYFNESFTF-DVSFEQIQKVQLVISVWDHDKMSRNDAIG--KIYLG-----------CDAT 348

  Fly  3699 GKELSLWQNMLDRPN----FW--------VEGSLVLRSSL 3726
            |.:|..|.:||..|.    .|        |:.:|.|:.:|
Zfish   349 GNQLRHWADMLSNPRKPVAQWHTLLSAEQVDTTLALKHTL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	42/121 (35%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	52/200 (26%)
syt8	NP_001352218.1	C2A_Synaptotagmin-1-5-6-9-10	106..229	CDD:176031	44/132 (33%)
syt8	NP_001352218.1	C2B_Synaptotagmin-1	238..372	CDD:176047	50/187 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010