Protein Alignment btsz and SYT15B

DIOPT Version :10

• Sequence 1: NP_001247109.1
• Gene: btsz / 3346167
• FlyBaseID: FBgn0266756
• Length: 3734
• Species: Drosophila melanogaster
• Sequence 2: NP_001357111.1
• Gene: SYT15B / 102724488
• HGNCID: 51487
• Length: 474
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 117/515 - (22%)
• Similarity: 181/515 - (35%)
• Gaps: 133/515 - (25%)

  Fly  3244 SATGSAKSARYRSPGLAARAAAVSGAGGGSSGGVGVGASSG---------STGKKLGAGFQFLY- 3298
            :.:||::||...|         .:|.|.|...|.|..|:||         ....:..||.|..:
Human    31 AVSGSSRSALRPS---------TAGPGPGPGTGWGGTAASGRWVPAPAVHCAAPRAAAGHQQHHG 86

  Fly  3299 --------SKRDARKRLNMSAEEAKVAAEELSRSPVIGQRQADGSGSP------IQSRASSETW- 3348
                    :.|..::|....|..|:.....|...|         .|.|      :........|
Human    87 PPLCSPDGAPRRFKRRPGSPAPAAQTGETSLREQP---------HGGPPAVPFVVPPTLQGRDWV 142

  Fly  3349 PTQSDEDID--------RLVAMHQNRSSLSS---LGVRSESMASVYSGAGEGRY--GTVVVKGQV 3400
            |..|.|..|        ..:..|.:...|..   :|..:..:........|..:  |.:   |::
Human   143 PLHSGEWADAPWDPCPASELLPHTSSGGLGDACMVGAINPELYKFPEDKSETDFPDGCL---GRL 204

  Fly  3401 EFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLNPIFD 3465
            .|:::|..:...|.|.:::.:.|   .|......|.||:|||||:.:..:.|||.|  |.||.||
Human   205 WFSVEYEQEAERLLVGLIKAQHL---QAPSETCSPLVKLYLLPDERRFLQSKTKRK--TSNPQFD 264

  Fly  3466 ETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLF--DNPQSQWYLLQERS-EPF 3527
            |...|.....::..|.|..:|:|.|...::..||:|...|:....  |..:..|..|:..| ||.
Human   265 EHFIFQVSSKTITQRVLKFSVYHVDRQRKHQLLGQVLFPLKNETLVGDCRRVIWRDLEAESLEPP 329

  Fly  3528 DEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQLHV 3592
            .|.    ||:...|.|       :.:.||                                 |.|
Human   330 SEF----GDLQFCLSY-------NDYLSR---------------------------------LTV 350

  Fly  3593 LVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEELSER 3657
            :|..||.|...:..|....|.|..|:........:||..|..:::|.:|.||.:: ....||...
Human   351 VVLRAKGLRLQEDRGIVSVFVKVSLMNHNKFVKCKKTSAVLGSINPVYNETFSFK-ADATELDTA 414

  Fly  3658 ALELTV---WDHDRLASNEFVGGIRFSLGTGRSYGRQV--EWMDATGKELSLWQNMLDRP 3712
            :|.|||   .:.|:                .:..||.|  .:|...|:||..|..||.:|
Human   415 SLSLTVVQNMEGDK----------------SQQLGRVVVGPYMYTRGRELEHWDEMLSKP 458

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		Atrophin-1	<299..>500	CDD:460830
		C2A_SLP	3398..3520	CDD:176056	37/123 (30%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	41/184 (22%)
SYT15B	NP_001357111.1	C2A_Synaptotagmin-15-17	202..322	CDD:176036	37/124 (30%)
		C2B_Synaptotagmin-15	332..469	CDD:176054	41/188 (22%)