DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and sytl4

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_031746962.1	Gene:	sytl4 / 100495134	XenbaseID:	XB-GENE-958567	Length:	692	Species:	Xenopus tropicalis

Alignment Length:	657	Identity:	218/657 - (33%)
Similarity:	322/657 - (49%)	Gaps:	115/657 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly  3100 RRSAGDLLFSQHQQSLSREQLDRVRSCGSIGGGDAHHHQLESSPAKPWLSSAGSSIGGDSTKDVR 3164
            ::|.||..:.|           ||....:..|.|.....|...|      ||.           :
Frog   117 KKSTGDWFYDQ-----------RVNRFANRLGRDMVRMSLRQKP------SAN-----------K 153

  Fly  3165 RSSVPDAIYETDSSDEAASHQFGGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTKS 3229
            |.:...|:.|                  ..:.||..:...:..| |:......|:|.....|:.:
Frog   154 RETTAQALLE------------------FSQQLNEPKTRKAQRS-PQQQHKSSGSPDLRDQKSDT 199

  Fly  3230 QSALNHTPSNLSTVSATGSAKSARYRSPGLAA------RAAAVSGAG---------------GGS 3273
            :|....:.|:..|.|...|..::|..|...:|      ||....||.               ..|
Frog   200 ESTEQMSLSSYKTDSKKSSPSTSRRNSLEKSATLQDAKRAQGPVGANVATLTVPVRSRDRHQSDS 264

  Fly  3274 SGGVGVGA-SSGSTGKKLGAGFQFLYSKRDARKRLNMSAEEAKVAAEELSRSPVIGQRQADGSGS 3337
            .|...:|: |:||..:.     ..|:.|..  :||...|:.:| :..:|...|...:..|.|..|
Frog   265 EGEALLGSRSAGSADES-----DTLFKKNP--RRLLKPADYSK-SVLDLRPEPAAPEENALGDRS 321

  Fly  3338 PIQSRASSETWPTQSDEDIDRLVAMHQ---NRSSLSSLGVRSE---SMASVYSGAGEGRYGTVVV 3396
            ....|.:.|.  .:.|||||.||.:|:   .||||.| |..|.   ||.|:||.||:  :|.|::
Frog   322 KSVPRLNIEM--EEEDEDIDNLVEIHRLSAGRSSLRS-GASSSTLGSMISIYSEAGD--FGNVII 381

  Fly  3397 KGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVYLLPDKSKAGKRKTKVKKHTLN 3461
            .|::.|::.|:.|:..|.:.|..|::||..|..:.||:||:|.|||||||:.|||||.:|::|.|
Frog   382 TGEIIFSINYDAKVQLLNILVKECRNLAYGDELKMRSNPYIKSYLLPDKSRQGKRKTTIKRNTTN 446

  Fly  3462 PIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNLQGRLFDNPQSQWYLLQERSEP 3526
            |:::|.:::..|.|.|..|:|.|:|||.|.||||.|||:|.:.|....||:...:...|..:...
Frog   447 PMYNEVLKYIVPESMLHLRSLELSVWHYDRFGRNTFLGQVDIPLDSWNFDSLIEECLPLHGKGNM 511

  Fly  3527 FDEVATY--RGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLRKFGGSIKSVASKSERTSKGGQ 3589
            ......|  :|::||.|||:||..             .|.|..||            ::..:||:
Frog   512 DSGAGFYNSKGELVVSLKYVPPTK-------------PSGSERRK------------KKADEGGE 551

  Fly  3590 LHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVKRTLHPSWNYTFVYEDVSLEEL 3654
            |||.:||||:|:.:|..|..|:|.|.||.|.:.:::|:||||||:||:|.:|:||||..:..|:|
Frog   552 LHVWIKEAKNLTAVKTGGISDSFVKGYLFPHKNKNTKRKTPVVKKTLNPHYNHTFVYNGIKPEDL 616

  Fly  3655 SERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDATGKELSLWQNMLDRPNFWVEGS 3719
            ....|||||||.:.|:||:|:||:|..:|.|.|.|..|:|||:||:||||||.|...|..|.||:
Frog   617 QNVCLELTVWDREPLSSNDFLGGVRLGIGNGMSNGELVDWMDSTGEELSLWQKMRQYPGSWAEGT 681

  Fly  3720 LVLRSSL 3726
            |.||.|:
Frog   682 LQLRPSM 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	53/121 (44%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	83/188 (44%)
sytl4	XP_031746962.1	PHD_SF	15..126	CDD:419867	3/8 (38%)
		FYVE_Slp4	63..112	CDD:277303
		C2A_SLP-4_5	382..506	CDD:175995	53/123 (43%)
		C2B_SLP_1-2-3-4	521..685	CDD:175987	83/188 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	127	1.000	Domainoid score	I5301
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8454
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004380
OrthoInspector	1	1.000	-	-		otm72277
Panther	1	1.100	-	-	O	PTHR45716
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.010