DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btsz and syt6a

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_017209198.1	Gene:	syt6a / 100149310	ZFINID:	ZDB-GENE-090601-2	Length:	537	Species:	Danio rerio

Alignment Length:	409	Identity:	108/409 - (26%)
Similarity:	175/409 - (42%)	Gaps:	97/409 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3329 QRQADGSGSPIQSRASSETWPTQ---------SDEDIDRLVAMHQNRSSLSSLG---------VR 3375
            |||.....|..:..:.....|.|         .|.|:|         ...:|:|         :.
Zfish   169 QRQTTEPASSTRHSSFKRHLPRQMQVSSLDLGDDYDVD---------EQPTSIGRIKPELYKQMT 224

  Fly  3376 SESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVKVY 3440
            :|:..|..|..|:.       .|::.|:::|:|:...|.|.:::..||.|.|. ...||||||:|
Zfish   225 TENDESANSKGGKN-------CGKINFSLRYDYENEMLLVKILKAFDLPAKDL-CGSSDPYVKIY 281

  Fly  3441 LLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSVNL 3505
            ||||:.:  |.:|:|.:.||||.|||:.:|..|...|..|.|.|:|:..|.|.|:|.:|||.::
Zfish   282 LLPDRKQ--KFQTRVHRKTLNPTFDESFQFPVPYDELAVRKLHLSVFDFDRFSRHDMIGEVILD- 343

  Fly  3506 QGRLFD-----NPQSQWYLLQ-ERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSS 3564
              .||:     ...|.|..:| ..||..|     .|:|:..|.|:|
Zfish   344 --NLFEVSDLSRETSIWRDIQYATSESVD-----LGEIMFSLCYLP------------------- 382

  Fly  3565 SNLRKFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKT 3629
                                 ..|:|.:.|.:.::|..:...|..|.:.|..|:.|..|..|:||
Zfish   383 ---------------------TAGRLTLTVIKCRNLKAMDITGYSDPYVKVSLICDGRRLKKKKT 426

  Fly  3630 PVVKRTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGT---GRSYGRQ 3691
            ...|.||:|::|...:: |:..|.:.:.:|.::|.|:|.:..||.:|..|...|.   ||.:..
Zfish   427 TTKKNTLNPTYNEAIIF-DIPPESMDQVSLHISVMDYDLVGHNEIIGVCRLGCGAEGLGRDHWN- 489

  Fly  3692 VEWMDATGKELSLWQNMLD 3710
             |.:....|.::.|..:|:
Zfish   490 -EMLAYPRKPIAHWHPLLE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	49/126 (39%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	40/180 (22%)
syt6a	XP_017209198.1	C2A_Synaptotagmin-1-5-6-9-10	238..363	CDD:176031	49/137 (36%)
syt6a	XP_017209198.1	C2B_Synaptotagmin-3-5-6-9-10	372..505	CDD:176048	39/175 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920