DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btsz and syt3

DIOPT Version :9

Sequence 1:	NP_001247109.1	Gene:	btsz / 3346167	FlyBaseID:	FBgn0266756	Length:	3734	Species:	Drosophila melanogaster
Sequence 2:	XP_005164031.1	Gene:	syt3 / 100000615	ZFINID:	ZDB-GENE-090601-1	Length:	566	Species:	Danio rerio

Alignment Length:	539	Identity:	141/539 - (26%)
Similarity:	223/539 - (41%)	Gaps:	125/539 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  3187 GGARSTLPRSLNPNQVVASTNSLPRLPTTGVGAPITSTPKTKSQSALNHTPSNLSTVSATGSAKS 3251
            ||..|.||..|......:|::..|.|...|                 .|.|
Zfish   110 GGGASLLPPLLQRKDTHSSSSLYPTLSQQG-----------------QHHP-------------- 143

  Fly  3252 ARYRSPGLAARAAAVSGAGGGSSGGVGVGASSGSTGKKLGAGFQFL----YSKRDARKRLNMSAE 3312
                      ..:.|.|..||  ||:.||...|  |.:......:|    |....|..:|:.::.
Zfish   144 ----------HFSDVMGVEGG--GGLVVGGVVG--GPQEMQEHSYLDMDSYPNNAATLKLSQTSP 194

  Fly  3313 EAKVAAEELSRSPVI----GQRQADGSGSPIQSRASSETWPTQSDEDIDRLVAMHQNRSSLSSLG 3373
            |...|.|..|.:..:    .|:|......|:..:.||..:  ..:|..::|.::.|.:..|..|.
Zfish   195 ELPPATEGGSAAKDLPNAHSQQQVTTRPKPMTHQLSSPDF--HGEEKSEQLTSIGQIKPELYRLR 257

  Fly  3374 VRSESMASVYSGAGEGRYGTVVVKGQVEFAMQYNYKLSALEVHVVRCKDLAAVDAKRNRSDPYVK 3438
            ...:         |:|:.|...  |::.|.::|.:....|.|.:::..||.|.|| ...||||||
Zfish   258 QGDQ---------GDGKQGNNC--GKISFLLRYAFNTEQLVVKILKALDLPAKDA-NGFSDPYVK 310

  Fly  3439 VYLLPDKSKAGKRKTKVKKHTLNPIFDETMRFHTPISSLESRTLWLTVWHSDMFGRNDFLGEVSV 3503
            :|||||:.|  |.:|||.:.||||:|:||.:|..|::.|.:|.|..:|:..|.|.|:|.:|:|.|
Zfish   311 IYLLPDRKK--KFQTKVHRKTLNPVFNETFQFGVPLAELHARKLHFSVYDFDRFSRHDLIGQVVV 373

  Fly  3504 NLQGRLFDNPQSQWYLLQERSEPFDEVATYRGDIVVGLKYIPPENIKSSFFSRGSSITGSSSNLR 3568
                   ||       |.:.||...|...:| |||.|                    |...::|.
Zfish   374 -------DN-------LLDFSEGTGEKPIWR-DIVEG--------------------TAEKADLG 403

  Fly  3569 KFGGSIKSVASKSERTSKGGQLHVLVKEAKHLSPIKANGTCDAFCKSYLLPDRTRSSKQKTPVVK 3633
            :...|:..:.:       .|:|.|.:.:|.:|..:...|..|.:.|:.|:.:..|..|:||.:.|
Zfish   404 ELNFSLCYLPT-------AGRLTVTIIKATNLKAMDLTGFSDPYVKASLVCEGRRLKKRKTSIKK 461

  Fly  3634 RTLHPSWNYTFVYEDVSLEELSERALELTVWDHDRLASNEFVGGIRFSLGTGRSYGRQVEWMDAT 3698
            .||:|::|...|: |:..|.:...:|.:.|.|:|.:..||.:|..|  :|:           ||.
Zfish   462 NTLNPTYNEALVF-DIPNENIESVSLIIAVMDYDCIGHNEVIGMCR--MGS-----------DAD 512

  Fly  3699 GKELSLWQNMLDRPNFWVE 3717
            |.....|..||..|...:|
Zfish   513 GPGREHWTAMLANPRKPIE 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btsz	NP_001247109.1	FYVE_Slp3_4_5	26..73	CDD:277286
		SOBP	<300..476	CDD:291927
		C2A_SLP	3398..3520	CDD:176056	48/121 (40%)
		C2B_SLP_1-2-3-4	3534..3723	CDD:175987	46/184 (25%)
syt3	XP_005164031.1	C2A_Synaptotagmin-1-5-6-9-10	269..394	CDD:176031	55/144 (38%)
syt3	XP_005164031.1	C2B_Synaptotagmin-3-5-6-9-10	403..536	CDD:176048	39/150 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D925064at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920