Protein Alignment Gfrl and gfra1b

DIOPT Version :10

• Sequence 1: NP_001247206.1
• Gene: Gfrl / 3346162
• FlyBaseID: FBgn0262869
• Length: 1279
• Species: Drosophila melanogaster
• Sequence 2: NP_571806.1
• Gene: gfra1b / 79377
• ZFINID: ZDB-GENE-010226-3
• Length: 481
• Species: Danio rerio
• Alignment Length: 329
• Identity: 75/329 - (22%)
• Similarity: 111/329 - (33%)
• Gaps: 80/329 - (24%)

  Fly    60 PTDKSLSSATTALETDLAIGRSGSTIKGVVAIL---NCILARQLCFEDPSCSAILEIIPRVCGPI 121
            |.:..||.          |.|....|.|..|..   ||:.|.:.|..:.:|.....:....|
Zfish   135 PVNSRLSD----------IFRLAPIISGEAAFTKDNNCLNAAKACNLNDTCKKYRSLYISPC--- 186

  Fly   122 PVSCSTVTVT------KCQAALRTLQAFQFFRPT----------CLCKEPGMDPDCNHFRDFLFD 170
               .|.|:.|      ||..|||     |||...          |.|.. |....|:..|.....
Zfish   187 ---TSRVSTTEVCNKRKCHKALR-----QFFDKVPPKHSYGMLFCSCPS-GDHSACSERRRQTIV 242

  Fly   171 HPCGFVLKKAEKDPYPIDALPTCNHALSVCQQERKCLKLFEDFKTHCKVRDNK---CKMENRDAC 232
            ..|.:  :..||        |.|....:.|:....|.....||.|:|:.....   |..||...|
Zfish   243 PACSY--EDKEK--------PNCLSLQASCKTNYICRSRLADFLTNCQPEARSISGCLKENYADC 297

  Fly   233 HDSWTNL---------------RLSPMFGCICPNN-HMKKRCDRIFNIVNHNPCVDRLI-FFPNG 280
            ..:::.|               .:||.  |.|.|: :.|..||:......:|.|:...| .|.||
Zfish   298 LLAYSGLIGTVMTPNYLRAPGISVSPW--CDCSNSGNGKAECDKFTEFFTNNRCLRNAIQAFGNG 360

  Fly   281 LP-KLKQPRPKAKPRPKPKPKSKPKPRQRHHGMNGTELMTNNIEYHDEP-----NGLSDPEDEAN 339
            .. .:.||:|.....| ..|.:.||.|.|.........:||:::.:.:.     ..|...:.::|
Zfish   361 TDVGVWQPQPPIMSTP-ADPYTPPKGRDRTSNALDDPTLTNDLDSNADHLYSFCGSLQAQKLKSN 424

  Fly   340 ETVD 343
            .|:|
Zfish   425 VTLD 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:460537	21/94 (22%)
		GDNF	193..270	CDD:460537	21/95 (22%)
		GDNF	641..727	CDD:197975
		GDNF	751..832	CDD:460537
gfra1b	NP_571806.1	GDNF	41..123	CDD:197975
		GDNF	162..245	CDD:197975	21/94 (22%)
		GDNF	255..349	CDD:460537	21/95 (22%)