DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfrl and gfra1a

DIOPT Version :9

Sequence 1:	NP_001247206.1	Gene:	Gfrl / 3346162	FlyBaseID:	FBgn0262869	Length:	1279	Species:	Drosophila melanogaster
Sequence 2:	NP_571805.1	Gene:	gfra1a / 79376	ZFINID:	ZDB-GENE-010226-2	Length:	472	Species:	Danio rerio

Alignment Length:	469	Identity:	82/469 - (17%)
Similarity:	143/469 - (30%)	Gaps:	170/469 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   615 GVY-YQSGQDVEVDLSTEIIKQHF------------------QSTCHTALDTCREDPSCSSSLQP 660
            |:| :..|.|:..|...|.:....                  ::.|..|...|..:.:|......
Zfish   108 GIYQHLQGNDLLEDSPYEPVNSRLSDIFRLAPIYSGEPALAKENNCLNAAKACNLNDTCKKYRSA 172

  Fly   661 MLTHC-----ELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDMCMIAQ 720
            .::.|     ....||:..|..:|:.|:.......:..:.:|.|  ....|:....|.      :
Zfish   173 YISPCTSRVSTAEVCNKRKCHKALRQFFDKVPPKHSYGMLYCSC--PLGDQSACSERR------R 229

  Fly   721 EKLHPVCAQRPPDNSNPASSNGIYYHPPPACHVVADSCKEDRECRLKLEYYEQACAVD--SVTKK 783
            :.:.|.|:....:.              |.|..:..|||.:..||.:|..:...|..:  |::..
Zfish   230 QTIVPACSYEDKER--------------PNCLTLQVSCKTNYICRSRLADFFTNCQPEPLSLSGC 280

  Fly   784 CAGRPSGCRTAMIGILGTMLRTT--------------CACQGTDPQHLYQCVGWRRLLWMNPCVV 834
            .....:.|..:..|::||::...              |:..|...:   :|..:......|.|:.
Zfish   281 LKENYADCLLSYSGLIGTVMTPNYLRSPKISVSPFCDCSSSGNSKE---ECDRFTEFFTDNACLR 342

  Fly   835 EAQKDFHMKRLAELGFLTTTTTTTTTTTTTTTTTTTRAPPPPPPPTTTTTTTTSMQPRQTPR--- 896
            .|.:.|                       ...|..:...|.||..|||:.||.|.:.|...|
Zfish   343 NAIQAF-----------------------GNGTDVSVWHPMPPVQTTTSMTTPSQRARDKDRSPN 384

  Fly   897 --KPATHIFKDVITAKEKSEPTSVEHNYLDPPDSIPLPSVNVESGGNGGNDDYHNGNGNGHGNGN 959
              :|||||                  |:|:|.|                       |......||
Zfish   385 AIEPATHI------------------NHLNPAD-----------------------NSLYQFCGN 408

  Fly   960 GNGRRKNGGKGRGGSVDFDDPVIFVDPRETTEFVGISITEPVTTTTTTMATTTTTQPPRNCVVQR 1024
            ...::|.    ...::|    |:.|||:         |.:|.::.|.:..::
Zfish   409 IQAQKKK----TNNTID----VLCVDPQ---------IDDPSSSNTISKNSS------------- 443

  Fly  1025 PRQ------SDQLI 1032
            |||      |.||:
Zfish   444 PRQMTLSGLSSQLL 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506
		GDNF	193..270	CDD:197975
		GDNF	641..727	CDD:197975	15/90 (17%)
		GDNF	751..832	CDD:280506	17/96 (18%)
gfra1a	NP_571805.1	GDNF	32..114	CDD:197975	2/5 (40%)
		GDNF	153..236	CDD:280506	15/90 (17%)
		GDNF	246..340	CDD:280506	17/96 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584249
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940