Protein Alignment Gfrl and Gfrl

DIOPT Version :10

• Sequence 1: NP_001247206.1
• Gene: Gfrl / 3346162
• FlyBaseID: FBgn0262869
• Length: 1279
• Species: Drosophila melanogaster
• Sequence 2: XP_061497849.1
• Gene: Gfrl / 5667534
• VectorBaseID: AGAMI1_000291
• Length: 1210
• Species: Anopheles gambiae
• Alignment Length: 1340
• Identity: 626/1340 - (46%)
• Similarity: 755/1340 - (56%)
• Gaps: 340/1340 - (25%)

  Fly    18 LWVVLFGGALHLAQ--------GSEFPERECCDLTTTSTVGPLPMPPAALPTDK-SLSSA----- 68
            |.|.|.|.||.:.|        |||||||||||........|.|:|..|.||.. |.||:
Mosquito    57 LLVALLGPALEVRQGPSTTGVSGSEFPERECCDPVYPPMPDPDPVPGPAYPTTTISTSSSFQTGQ 121

  Fly    69 -----------------TTALETDLA-------------------IGRSGSTIKGVVAILNCILA 97
                             :||:..:|.                   ||.|||.||..:||||||||
Mosquito   122 SGIGGGGLIGGGTGAGGSTAVGNELGGGLIGTGSGSQLSSSRPMHIGYSGSNIKTAIAILNCILA 186

  Fly    98 RQLCFEDPSCSAILEIIPRVCGPIPVSCSTVTVTKCQAALRTLQAFQFFRPTCLCKEPGMDPDCN 162
            |||||||||||||||||||||||:||:|||||||||||||||||||.||||||||||||:|||||
Mosquito   187 RQLCFEDPSCSAILEIIPRVCGPVPVACSTVTVTKCQAALRTLQAFPFFRPTCLCKEPGIDPDCN 251

  Fly   163 HFRDFLFDHPCGFVLKKAEKDPYPIDALPTCNHALSVCQQERKCLKLFEDFKTHCKVRDNKCKME 227
            :|||||||||||||.|| ||||||:|||||||||||||||||||:|||||||.|||||:|||:||
Mosquito   252 YFRDFLFDHPCGFVSKK-EKDPYPVDALPTCNHALSVCQQERKCIKLFEDFKLHCKVRENKCRME 315

  Fly   228 NRDACHDSWTNLRLSPMFGCICPNNHMKKRCDRIFNIVNHNPCVDRL-------------IFFPN 279
            :||.|:::||||||||||||||||||||:|||:||::||||||||.|             ..:||
Mosquito   316 DRDLCYEAWTNLRLSPMFGCICPNNHMKRRCDKIFSVVNHNPCVDVLPSALDISSGTATNSIYPN 380

  Fly   280 GLPK--LKQPRPKAK------PRPKPKPKSKPKPRQRHHGMNGTELMTNNIEYHDEP-------- 328
            ..|.  ::.|.|.:.      |..|..|.:           .|:.:....::|.:.|
Mosquito   381 FFPSDIIEDPPPTSTYPYFLFPSKKYPPSA-----------FGSAIYHATVDYINLPDGPGTGTT 434

  Fly   329 NGLSDPEDEANETVDEDPGGHGDEDEDEEDDDYDDRIRAEIYSNYPHYLHPP---SWGINNPLVL 390
            ||.|...|:::.:......||..:....| ..|..|......::..|..|..   |.|.|.|:.
Mosquito   435 NGSSPDTDQSSSSSSSSSPGHPRQHSGTE-HSYRTRYEHNFDTSMHHTKHQSPTHSSGNNAPIA- 497

  Fly   391 ASHSPHTLDDDDDVVVEVVANKKPPPVTLHHHNDELDHDVVVVVDAGPHSHSHPHSHTFYSHGDQ 455
                                   ||....|.|..:                  ||.|.::..|:.
Mosquito   498 -----------------------PPWPDQHQHQQQ------------------PHQHPYWHGGEN 521

  Fly   456 SSTTGSGLPGPAPTIPSPPNTGTKMHKTAPLGDLVAGSDITHRTYTGPSMDERVRILGMDEKLHQ 520
            .:...:|..|          ||.....:.|       ||:..:..|          :|.|
Mosquito   522 GTADTAGHVG----------TGRWDSMSVP-------SDLQQQPET----------VGSD----- 554

  Fly   521 RIFNDNLALIDTPLIAMGSGSGSGTVTTSVSGYGLGMGMGLSGSFNYLGSMHGVPSYPFNISGFH 585
                                                                             
Mosquito   555 ----------------------------------------------------------------- 554

  Fly   586 QRHMAAAAADNEPFDIIDTGLGYGGNGNAGVYYQSGQDVEVDLSTEIIKQHFQSTCHTALDTCRE 650
                                                 |:| :...|:...|||||||.|||:||:
Mosquito   555 -------------------------------------DIE-EKEAEMSFIHFQSTCHLALDSCRD 581

  Fly   651 DPSCSSSLQPMLTHCELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDM 715
            |..|||:|:.:|.||:.|||||||||.|||:|||..|:||:||||||||:||.       ||||.
Mosquito   582 DQVCSSALKTVLMHCDQHRCNRNACMESLQSFYKSIHDDLSLDIAFCLCRKTP-------NRHDS 639

  Fly   716 CMIAQEKLHPVCAQRPPDN----SNPASSNGIYYHPPPACHVVADSCKEDRECRLKLEYYEQACA 776
            |||||||||||||||||::    .:.::.|||.|:.|||||.||:.|:||.:||.:||.:||:||
Mosquito   640 CMIAQEKLHPVCAQRPPESLSQQQSSSTGNGIAYNAPPACHAVAELCREDEDCRARLEVFEQSCA 704

  Fly   777 VDSVTKKCAGRPSGCRTAMIGILGTMLRTTCACQGTDPQHLYQCVGWRRLLWMNPCVVEAQKDFH 841
            ||||||||||:.|.||.||:|||||.|||||||||:|.|.||.|:||:||||:||||||:|||||
Mosquito   705 VDSVTKKCAGKTSACRQAMLGILGTPLRTTCACQGSDMQQLYDCLGWQRLLWLNPCVVESQKDFH 769

  Fly   842 MKRLAELGFLTTTTTTTTTTTTTTTTTTTRAP----PPPPPPTTTTTTTTSMQPRQTPR-KPATH 901
            :|||||||.||||||..|||||.|||||.|:.    ||..|||         :|:...| ||
Mosquito   770 LKRLAELGLLTTTTTMATTTTTMTTTTTMRSTRITHPPTLPPT---------KPKPVYRPKP--- 822

  Fly   902 IFKDVITAKEKSEPTSVEHNYLDPPDSIPLPSVNVESG-------GNGGN----DDYHNGNGNGH 955
                       :|..::|.||::.||:.|...|:.::|       ..|.:    |:|....|..|
Mosquito   823 -----------TEMHTIETNYVETPDTRPETLVHNQNGLIERTDLDRGHSPPQPDEYDRSTGTRH 876

  Fly   956 GNGNGN-------GRRKNGGKGRGGSVDFDDPVIFVDPRETTEFVGISITEPVTTTTTTMATTTT 1013
            ...:.:       ||...|...|.     |:.|:.|   .:||...:....|.|.||||...|||
Mosquito   877 QPVDSDSEDDDMVGRYDKGIYQRP-----DEQVLHV---ASTEVQELETFPPTTVTTTTTEPTTT 933

  Fly  1014 TQPPRNCVVQRPRQSDQLIREGSSKRIYSLDDVECSELCSC--GESLILTCHALCVPFAPCRTAL 1076
            ..|.|.|||||..|.||||.||.|:|:|.|||.||||||:|  |:||.|||||||||.|||||||
Mosquito   934 PVPIRYCVVQRSHQPDQLIAEGKSRRLYILDDAECSELCTCGGGDSLALTCHALCVPLAPCRTAL 998

  Fly  1077 AFYSHASPAYQAFRGRCLCYSGRFICMKPPLGEYILPGGIFLLLGYSAADEALLRPHTNLGVQDA 1141
            |:||||:||||||||||||||||||||:||.|||.||||||||||||:.||||||||||||||||
Mosquito   999 AYYSHAAPAYQAFRGRCLCYSGRFICMRPPPGEYQLPGGIFLLLGYSSTDEALLRPHTNLGVQDA 1063

  Fly  1142 VRALQQYVTTYIDNQTQCTLTLFNMTEENIIIAARLPHDGKLKDIELLRKEKDECTAILKTISHQ 1206
            ||||||||..:|||.|.|||||||:||||||::.|||.|.||..::||:.|||:||.||:|||||
Mosquito  1064 VRALQQYVLQHIDNSTHCTLTLFNITEENIILSIRLPLDPKLTPMQLLKMEKDQCTRILETISHQ 1128

  Fly  1207 INSEHSELQSHRLLSIFKMSEVEVVWPESTSAAARSGHGP 1246
            ||:::.||.:|||||||||:||::|||| .|.|.|:...|
Mosquito  1129 INTQYVELSAHRLLSIFKMAEVQIVWPE-VSYARRNTTPP 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:460537	73/78 (94%)
		GDNF	193..270	CDD:460537	63/76 (83%)
		GDNF	641..727	CDD:197975	57/85 (67%)
		GDNF	751..832	CDD:460537	56/80 (70%)
Gfrl	XP_061497849.1	None