DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfrl and gfral

DIOPT Version :9

Sequence 1:	NP_001247206.1	Gene:	Gfrl / 3346162	FlyBaseID:	FBgn0262869	Length:	1279	Species:	Drosophila melanogaster
Sequence 2:	XP_689825.7	Gene:	gfral / 561326	ZFINID:	ZDB-GENE-110607-2	Length:	433	Species:	Danio rerio

Alignment Length:	200	Identity:	45/200 - (22%)
Similarity:	68/200 - (34%)	Gaps:	40/200 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   636 HFQSTCHTALDTCREDPSCSSSLQPMLTHCELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCK 700
            |....|...:..|..:.||:..:.|:|..|:...||:  |..:::.||......:...:.||.|
Zfish   125 HADRPCLEEIAACLGEESCNRPMVPLLQECKASSCNQ--CTEAIRQFYSALPHSVAETLVFCEC- 186

  Fly   701 KTSSQQNGNGNRHDMCMIAQEKLH-PVCAQRPPDNSNPASSNGIYYHPPPACHVVADSCKEDREC 764
                     |.:...|...:..:| ..|.......             |..|....|||.||..|
Zfish   187 ---------GAQDQQCQEMKALIHYGSCVSEQTQT-------------PWTCLEALDSCFEDASC 229

  Fly   765 RLKLEYYEQAC------AVDSVTKKC--------AGRPSGCRTAMIGILGTMLRTTCACQGTDPQ 815
            |...:.:...|      |.||.:...        .|....||.|.:..:|::|...|.|.|....
Zfish   230 RQVFDGFLSKCFEAEESAFDSTSDWLYLLDPDFFLGEDVECRAAFVETVGSVLHHPCTCAGLHHH 294

  Fly   816 HLYQC 820
            |.|:|
Zfish   295 HQYKC 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506
		GDNF	193..270	CDD:197975
		GDNF	641..727	CDD:197975	18/86 (21%)
		GDNF	751..832	CDD:280506	23/83 (28%)
gfral	XP_689825.7	GDNF	130..205	CDD:308135	18/86 (21%)
gfral	XP_689825.7	GDNF	216..310	CDD:308135	23/83 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584247
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10269
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5065
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.970