DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfrl and gfra3

DIOPT Version :9

Sequence 1:	NP_001247206.1	Gene:	Gfrl / 3346162	FlyBaseID:	FBgn0262869	Length:	1279	Species:	Drosophila melanogaster
Sequence 2:	NP_001243565.1	Gene:	gfra3 / 556647	ZFINID:	ZDB-GENE-110512-1	Length:	458	Species:	Danio rerio

Alignment Length:	366	Identity:	77/366 - (21%)
Similarity:	125/366 - (34%)	Gaps:	116/366 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   622 QDVEVDL--STEIIKQHF-----------QSTCHTALDTC----------REDPSCSSSLQPMLT 663
            :|:|::|  :||..|...           |:.|..|...|          .|..|..:.:.|...
Zfish   120 EDIELELVRNTETSKLASIVSVSSLPLTDQNQCLKAAQDCGLYEKCGSLRSEYASACTKILPNTN 184

  Fly   664 HCELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDMCMIAQEKLHPVCA 728
            ||..|:|:|     :|:.|.:...|:.:..:.||.|..|..     |.|.      ::.:.|.|:
Zfish   185 HCNRHKCHR-----ALRRFLERVPEEYSFGVLFCPCSDTLC-----GERR------RKTIVPSCS 233

  Fly   729 QRPPDNSNPASSNGIYYHPPPACHVVADSCKEDRECRLKLEYYEQACAVDSVTKKCAGRPSG--C 791
            ....|..             |.|..:...|.:|..||.:|..::|.|...|::.....|.||  |
Zfish   234 YEERDGQ-------------PNCLHLESYCLKDNLCRSRLADFQQNCQPSSLSPSGCLRDSGAVC 285

  Fly   792 RTAMIGILGTMLRTT------------CACQGTDPQHLYQCVGWR---RLLWM---NPCVVEAQK 838
            ..|..|::||::...            |.|:|:..|       |:   |:|.|   |.|:..|
Zfish   286 LKAYAGLIGTIMTPNYVSNSSTEVSQWCNCEGSGNQ-------WQDCLRILHMFNSNTCLRNA-- 341

  Fly   839 DFHMKRLAELGFLTTTTTTTTTTTTTTTTTTTRAPPPPPPPTTTTTTTTSMQPRQTPRKPATHIF 903
                  :..:|           ::|......|..|||.|.|   ......:.....|...|....
Zfish   342 ------IDNMG-----------SSTPRPVEGTPLPPPRPSP---QVQRDELNINLLPEPNAVEES 386

  Fly   904 KDVITAKEKSEPTSVEHNYLDPPDSIPLPSVNVESGGNGGN 944
            ::|...:::.|....|.|               ::||.|.|
Zfish   387 EEVEEEEQEEEEEEEEEN---------------QAGGGGFN 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506
		GDNF	193..270	CDD:197975
		GDNF	641..727	CDD:197975	21/95 (22%)
		GDNF	751..832	CDD:280506	26/100 (26%)
gfra3	NP_001243565.1	GDNF	152..232	CDD:280506	21/95 (22%)
gfra3	NP_001243565.1	GDNF	243..337	CDD:280506	26/100 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940