Protein Alignment Gfrl and Gfral

DIOPT Version :10

• Sequence 1: NP_001247206.1
• Gene: Gfrl / 3346162
• FlyBaseID: FBgn0262869
• Length: 1279
• Species: Drosophila melanogaster
• Sequence 2: NP_001388718.1
• Gene: Gfral / 501023
• RGDID: 1565220
• Length: 540
• Species: Rattus norvegicus
• Alignment Length: 266
• Identity: 62/266 - (23%)
• Similarity: 106/266 - (39%)
• Gaps: 63/266 - (23%)

  Fly   617 YYQSGQD-VEVDLSTEIIKQHFQSTCHTALDTCREDPSCSSSLQPMLTHCEL--HRCNRNACMSS 678
            :.|..|| .:.|:::. .||  ..:|....:.|..|..|::.|...|..|..  :.|:...|.::
  Rat   256 FSQDNQDGFKEDVASG-FKQ--MQSCLEVTEACVGDVVCNAQLALYLKACTANGNLCDVKHCQAA 317

  Fly   679 LQAFYKGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDMCMIAQEKLHPVCAQRPPDNSNPASSNGI 743
            ::.||:....:....:|||.|.::...          |..::|.||          |.|.:.|.:
  Rat   318 IRFFYQNMPFNTAQMLAFCDCAQSDIP----------CQQSKETLH----------SKPCALNVV 362

  Fly   744 YYHPPPACHVVADSCKEDRECRLKLEYYEQAC-------------AVDSVTKK---CAGRPSGCR 792
               |||.|..|..:|:.|..||.....::..|             .:..:.|:   |:|..| ||
  Rat   363 ---PPPTCLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCREDETCISMLGKQDLTCSGSDS-CR 423

  Fly   793 TAMIGILGTMLRTTCAC----QGTDPQHLYQCVGWRRLLWMNPCV---------VEAQKDFHMKR 844
            .|.:|..||:|:..|||    ||.:|    .|:.::.:|....|.         :.:.:..|.|.
  Rat   424 AAYLGTFGTVLQVPCACRSITQGEEP----LCMAFQHMLHSKSCFNYPTPNVKDISSYERKHSKE 484

  Fly   845 LAELGF 850
            :...||
  Rat   485 ITLTGF 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:460537
		GDNF	193..270	CDD:460537
		GDNF	641..727	CDD:197975	19/87 (22%)
		GDNF	751..832	CDD:460537	26/100 (26%)
Gfral	NP_001388718.1	GDNF	278..357	CDD:460537	20/98 (20%)
		GDNF	367..463	CDD:460537	26/100 (26%)