DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gfrl and Gfral

DIOPT Version :10

Sequence 1:NP_001247206.1 Gene:Gfrl / 3346162 FlyBaseID:FBgn0262869 Length:1279 Species:Drosophila melanogaster
Sequence 2:NP_995316.2 Gene:Gfral / 404194 MGIID:3607786 Length:393 Species:Mus musculus


Alignment Length:211 Identity:50/211 - (23%)
Similarity:86/211 - (40%) Gaps:42/211 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   640 TCHTALDTCREDPSCSSSLQPMLTHCEL--HRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKT 702
            :|....:.|..|..|::.|...|..|..  :.|:...|.::::.||:....:....:|||.|.::
Mouse   130 SCLEVTEACVGDVVCNAQLALYLKACSANGNLCDVKHCQAAIRFFYQNMPFNTAQMLAFCDCAQS 194

  Fly   703 SSQQNGNGNRHDMCMIAQEKLHPVCAQRPPDNSNPASSNGIYYHPPPACHVVADSCKEDRECRLK 767
            ...          |..::|.||          |.|.:.|.:   |||.|..|..:|:.|..||..
Mouse   195 DIP----------CQQSKETLH----------SKPCALNIV---PPPTCLSVIHTCRNDELCRTH 236

  Fly   768 LEYYEQAC-------------AVDSVTKK---CAGRPSGCRTAMIGILGTMLRTTCACQGTDPQH 816
            ...::..|             .:..:.|:   |:|..| ||.|.:|..||:|:..|||:|.....
Mouse   237 YRTFQTECWPHITGKCHEDETCISMLGKQDLTCSGSES-CRAAFLGTFGTVLQVPCACRGVTQAE 300

  Fly   817 LYQCVGWRRLLWMNPC 832
            .:.|:.::.:|....|
Mouse   301 EHVCMIFQHMLHSKSC 316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GfrlNP_001247206.1 GDNF 94..173 CDD:460537
GDNF 193..270 CDD:460537
GDNF 641..727 CDD:197975 19/87 (22%)
GDNF 751..832 CDD:460537 24/96 (25%)
GfralNP_995316.2 GDNF 131..210 CDD:460537 20/98 (20%)
Required for interaction with GDF15. /evidence=ECO:0000250|UniProtKB:Q6UXV0 149..228 22/101 (22%)
GDNF 220..316 CDD:460537 24/96 (25%)
Blue background indicates that the domain is not in the aligned region.

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