DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gfrl and GFRA3

DIOPT Version :10

Sequence 1:NP_001247206.1 Gene:Gfrl / 3346162 FlyBaseID:FBgn0262869 Length:1279 Species:Drosophila melanogaster
Sequence 2:NP_001487.2 Gene:GFRA3 / 2676 HGNCID:4245 Length:400 Species:Homo sapiens


Alignment Length:392 Identity:78/392 - (19%)
Similarity:122/392 - (31%) Gaps:133/392 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 LSLWVVLFGGALHLAQGSEFP------------EREC-----C-------DLTTTSTVGPLPMPP 56
            |.|.::|....|.||.|...|            .|:|     |       |..|:|...|||...
Human    15 LMLLLLLPPSPLPLAAGDPLPTESRLMNSCLQARRKCQADPTCSAAYHHLDSCTSSISTPLPSEE 79

  Fly    57 AALPTD-------------------KSLSSATTALETDLAIGRSGS-------------TI---- 85
            .::|.|                   :.:.:....|:....:.|:.|             |:    
Human    80 PSVPADCLEAAQQLRNSSLIGCMCHRRMKNQVACLDIYWTVHRARSLGNYELDVSPYEDTVTSKP 144

  Fly    86 -KGVVAILN--------CILARQLCFEDPSCSAILEIIPRVC-GPIPVSCSTVTVTKCQAALRTL 140
             |..::.||        |:....||..:..|..:.:.....| ||           .||..:...
Human   145 WKMNLSKLNMLKPDSDLCLKFAMLCTLNDKCDRLRKAYGEACSGP-----------HCQRHVCLR 198

  Fly   141 QAFQFFRPTCLCKEPGMDPDCNHFRDFLF------DHPCGFVLKKAEKDPYPIDAL----PTCNH 195
            |...||       |...:|   |.:..|.      |..||   ::......|..||    |.|..
Human   199 QLLTFF-------EKAAEP---HAQGLLLCPCAPNDRGCG---ERRRNTIAPNCALPPVAPNCLE 250

  Fly   196 ALSVCQQERKCLKLFEDFKTHCKVRD--NKCKMENRDACHDSW-------------TNLRLSPMF 245
            ...:|..:..|.....||:|||...|  ..|..| :..|..::             :|:..|...
Human   251 LRRLCFSDPLCRSRLVDFQTHCHPMDILGTCATE-QSRCLRAYLGLIGTAMTPNFVSNVNTSVAL 314

  Fly   246 GCIC-PNNHMKKRCDRIFNIVNHNPCVDRLIF----FPNGLPKLKQPRP--------KAKPRPKP 297
            .|.| .:.::::.|:.:....:||||:...|.    |.:.|.....|.|        ...|..:|
Human   315 SCTCRGSGNLQEECEMLEGFFSHNPCLTEAIAAKMRFHSQLFSQDWPHPTFAVMAHQNENPAVRP 379

  Fly   298 KP 299
            :|
Human   380 QP 381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GfrlNP_001247206.1 GDNF 94..173 CDD:460537 17/85 (20%)
GDNF 193..270 CDD:460537 19/92 (21%)
GDNF 641..727 CDD:197975
GDNF 751..832 CDD:460537
GFRA3NP_001487.2 GDNF 44..124 CDD:197975 13/79 (16%)
GDNF 162..239 CDD:460537 20/100 (20%)
GDNF 248..340 CDD:460537 19/92 (21%)
Blue background indicates that the domain is not in the aligned region.

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