DRSC/TRiP Functional Genomics Resources

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Protein Alignment Gfrl and GFRA2

DIOPT Version :10

Sequence 1:NP_001247206.1 Gene:Gfrl / 3346162 FlyBaseID:FBgn0262869 Length:1279 Species:Drosophila melanogaster
Sequence 2:NP_001486.4 Gene:GFRA2 / 2675 HGNCID:4244 Length:464 Species:Homo sapiens


Alignment Length:335 Identity:77/335 - (22%)
Similarity:112/335 - (33%) Gaps:94/335 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 KILSCCLSLWVVLFGGALHLAQGSEFPERECCDLTTTSTVGPLPMPPAALPTDKSLSSATTALET 74
            |.|.|....|.:..|    |.:|.||.|..             |..|            .|:..:
Human   101 KELQCLQIYWSIHLG----LTEGEEFYEAS-------------PYEP------------VTSRLS 136

  Fly    75 D---LAIGRSGSTIKGVVAIL--NCILARQLCFEDPSC----SAILEIIPRVCGPIPVSCSTVTV 130
            |   ||...||:....||:..  :|:.|.:.|..:.:|    |:.:.|..|...|.. .|:.   
Human   137 DIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTE-RCNR--- 197

  Fly   131 TKCQAALRTLQAFQFFR--PT--------CLCKEPGMDPDCNHFRDFLFDHPCGFVLKKAEKDPY 185
            .||..|||     |||.  |:        |.|:    |..|...|.......|.:  :..||   
Human   198 RKCHKALR-----QFFDRVPSEYTYRMLFCSCQ----DQACAERRRQTILPSCSY--EDKEK--- 248

  Fly   186 PIDALPTCNHALSVCQQERKCLKLFEDFKTHCKV---RDNKCKMENRDACHDSW----------- 236
                 |.|.....||:.:..|.....||..:|:.   ....|..:|..||..|:           
Human   249 -----PNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPN 308

  Fly   237 ------TNLRLSPMFGCICPNNHMKKRCDRIFNIVNHNPCVDRLI-FFPNGLPKLKQPR-PKAKP 293
                  |.:.:||...|....| |::.|::.......|||:...| .|.||......|: |..:.
Human   309 YVDSSPTGIVVSPWCSCRGSGN-MEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQA 372

  Fly   294 RPKPKPKSKP 303
            ...|:.:..|
Human   373 TQAPRVEKTP 382

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GfrlNP_001247206.1 GDNF 94..173 CDD:460537 23/92 (25%)
GDNF 193..270 CDD:460537 20/96 (21%)
GDNF 641..727 CDD:197975
GDNF 751..832 CDD:460537
GFRA2NP_001486.4 GDNF 40..113 CDD:197975 4/11 (36%)
GDNF 161..241 CDD:460537 23/92 (25%)
GDNF 251..347 CDD:460537 20/96 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 363..392 4/20 (20%)
Blue background indicates that the domain is not in the aligned region.

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