Protein Alignment Gfrl and Y69A2AR.31

DIOPT Version :9

• Sequence 1: NP_001247206.1
• Gene: Gfrl / 3346162
• FlyBaseID: FBgn0262869
• Length: 1279
• Species: Drosophila melanogaster
• Sequence 2: NP_500240.2
• Gene: Y69A2AR.31 / 177049
• WormBaseID: WBGene00022100
• Length: 1066
• Species: Caenorhabditis elegans
• Alignment Length: 1357
• Identity: 258/1357 - (19%)
• Similarity: 403/1357 - (29%)
• Gaps: 510/1357 - (37%)

  Fly    93 NCILARQLCFEDPSCSAILEIIPRVCGPIPVSCSTVTVTKCQAALRTLQAFQFFRPTCLCKEP-G 156
            :|:..|.:|..:.:|:..|:.....||.....||..:.:.|...|..::.. |...:|.|.|. |
 Worm    22 SCLHYRSICLRNDTCNQHLKRFQTTCGYDLNVCSGTSPSDCVYYLHRIREI-FPTKSCTCYEAIG 85

  Fly   157 MDPDCNHFRDFLFDHPC-------GFVLK---------------KAEKDP---------YPI-DA 189
            ...:|:.||..:::|.|       |..:|               ..:|.|         .|: |.
 Worm    86 FSQECDFFRQIIWNHSCERKMRDVGEEIKLNNRKILRIETNRMQNVQKHPETSLRRTTRTPVADQ 150

  Fly   190 L------------------PTCNHAL-SVCQQERKCLKLFEDFKTHCKV-RDNKCKMENRDACHD 234
            :                  .||:.|| .||.:...|.:|:..|:.:|.| .||:|:|.:|:.|..
 Worm   151 IHQWKTQLSGELTKSKIEQKTCDAALYQVCLKHVSCSQLWSMFRKNCDVDLDNQCRMADREVCWQ 215

  Fly   235 SWTNLRLSPMFGCICPNNHMKKRCDRIFNIVNHNPCVDRLIFFPNGLPKLKQPRPKAKPRPKPKP 299
            |:..|..|.:..|.|.::: ...|..|....|:|.|:.. |......|.|.....|.:...:.|.
 Worm   216 SFEGLTWSGLGDCQCASSN-SSDCHWIRLHTNYNKCIYE-ISKSGQFPVLMTLAQKNREAEENKQ 278

  Fly   300 KSKPKPRQRHHGMNGTELMTNNIEYHDEPNGLSDPEDEANETVDEDPGGHGDEDEDEEDDDYDDR 364
            ::..:..:|.:                                           |:.|..:|
 Worm   279 RAMSEQYRRRY-------------------------------------------ENREQSEY--- 297

  Fly   365 IRAEIYSNYPHYLHPPSWGINNPLVLASHSPHTLDDDDDVVVEVVANKKPPPVTLHHHNDELDHD 429
            |..|:                         |.|........|        ||.|
 Worm   298 ILREV-------------------------PTTTTTTTTTTV--------PPTT----------- 318

  Fly   430 VVVVVDAGPHSHSHPHSHTFYSHGDQSSTTGSGLPGPAPTIPSPPNTGTK----MHKTAPLGDLV 490
                                    .:::||.:    |.||:|:.|.|.|.    ....||
 Worm   319 ------------------------TRTTTTTT----PRPTVPTVPRTTTVPSWWSSAQAP----- 350

  Fly   491 AGSDITHRTYTGPSMDERVRILGMDEKLHQRIFNDNLALID-TPLIAMGSGSGSGTVTTSVSGYG 554
                 .||. |.|....|::                 |:|| ||.:|.
 Worm   351 -----RHRD-TSPRQGFRLK-----------------AVIDPTPTVAQ----------------- 375

  Fly   555 LGMGMGLSGSFNYLGSMHGVPSYPFNISGFHQRHMAAAAADNEPFDIIDTGLGYGGNGNAGVYYQ 619
                   ...:.|.||....|      ..|..|
 Worm   376 -------ENYYTYQGSKMEFP------PAFRPR-------------------------------- 395

  Fly   620 SGQDVEVDLSTEIIKQHFQSTCHTALDTCREDPSCSSSLQPMLTHC-ELHRCNRNACMSSLQAFY 683
                          |...:|:|..|:..|.....|...|..:...| ....|.|..|..|||.|.
 Worm   396 --------------KSSLRSSCPDAIRRCESVDECRWHLGELRVRCASTASCQREECAQSLQRFV 446

  Fly   684 KGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDMCMIAQEKLHPVCAQRPPDNSNPASSNGIYYHPP 748
            ......|...|.||.|   :.:..|       |:..||.::|.|..|         |:|..
 Worm   447 TYVPFALIESIMFCHC---APEDEG-------CLTQQEIIYPKCLYR---------SSGYM---- 488

  Fly   749 PACHVVADSCKEDRECRLKLEYYEQA-CAVDSVTKKCAGRP-SGCRTAMIGILGTMLRTTCACQG 811
            ..|......|.:|:.|: .:.|..|| |.|.:  .:|:... ..||..::....::|...|.|:.
 Worm   489 QTCTQSVQKCDQDQRCK-HIRYAMQAHCPVRN--GECSKTSLDDCRRTLLTARASILEQPCFCKL 550

  Fly   812 TDPQHLYQCVGWRR-LLWMNPCVVEAQKDFH-------------------------------MKR 844
            :|    .||:..:. ::..|||:..|..::.                               |:|
 Worm   551 SD----VQCLAHQNSMIPTNPCIESAMIEYSRIMGYSKPGLATNRVQSTVEEAVDPPEPEPAMRR 611

  Fly   845 LAEL-----------------------------------GFLTTTTT---------TTTTTTTTT 865
            .|..                                   ...|:|||         ||.|..||.
 Worm   612 TASTINHQPITTVTFAPPTYQEPPRTTSRPYQNQQNNRKRMRTSTTTKAPRTTVPPTTVTVRTTK 676

  Fly   866 TTTTTRAPPPPPPPTTTTTTTTSMQPRQTPRKPATHIFKDV--ITAKEKSEPTSVEHNYLDPPDS 928
            |||||..||||||.|:..::                 |.|:  |..|::::.|..:..
 Worm   677 TTTTTTTPPPPPPVTSKKSS-----------------FLDLFGIFGKKETQTTVADRK------- 717

  Fly   929 IPLPSVNVESGGNGGNDDYHNGNGNGHGNGNGNGRRKNGGKGRGGSVDFDDPVIFVDPRETT--- 990
                |:|.|:..|...||.:|..                      .:| ::|:..:.....|
 Worm   718 ----SINSETIDNLPTDDENNEE----------------------QMD-EEPMTEIKKSSDTVQR 755

  Fly   991 --EFVGISITEPVTT--------------TTTTMATTTTTQPPRNCVVQRPRQSDQLIREGSSKR 1039
              :| ..::|.|:|:              ||||:.||....|...|..:.....:.....|:..|
 Worm   756 KPKF-RTTVTPPITSEAPPPWISTTPTAPTTTTVFTTHAPPPMEGCNTKDANGREIFTHIGAIMR 819

  Fly  1040 IYSLDDVECSELCSCGESLILTCHAL-CVPFAPCRTALAFYSHASPAYQAFRGRCLCYSGRFICM 1103
            .|......||..|.|.....|.|..: |:....|...|.........:...||.|.|.:|.|:|.
 Worm   820 KYVDWSGRCSTWCECESEDHLACEPVPCLDHGTCDAPLTTIEFGERVFLKDRGACYCETGNFVCE 884

  Fly  1104 KPPLGEYILPGGIFLLLGYSAADEALLR---PHTNL---------GVQDAVRALQQYVTTYIDNQ 1156
            .|.......| |:::.:|||..|..|:|   |...|         ...|....:|......:...
 Worm   885 FPEDSPETYP-GLYMSIGYSQKDVELIRKAVPREILDKAGFSSSDASTDIASRMQIAFERLLPKN 948

  Fly  1157 TQCTLTLFNMTEENIIIAARLPHDGKLKDIELLR-------KEKDECTAILKTISHQINSEHSEL 1214
            .||.:...|...|......|:...|:.:.....|       .||.....:.|...|...:|....
 Worm   949 LQCRIVTMNELSEPGNALYRIEWYGRNEMFNHTRTRWHSDGAEKICSPYVRKLADHFSLNESPRF 1013

  Fly  1215 QSHRLLSIFKMSEVEVV-----WPESTSAAARSGHGPGQFAGCDRLLYAAMLALAYL 1266
            |    |.:..:.:|:|:     .|:|:|..        .|.||       :|::.||
 Worm  1014 Q----LVLSTVKQVKVLDYLDGLPQSSSGR--------HFTGC-------LLSMYYL 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506	20/79 (25%)
		GDNF	193..270	CDD:197975	25/78 (32%)
		GDNF	641..727	CDD:197975	23/86 (27%)
		GDNF	751..832	CDD:280506	19/83 (23%)
Y69A2AR.31	NP_500240.2	GDNF	23..102	CDD:280506	20/79 (25%)
		GDNF	172..250	CDD:197975	25/78 (32%)
		GDNF	403..480	CDD:197975	23/86 (27%)
		GDNF	491..568	CDD:197975	19/83 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C9WE
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	179	1.000	Inparanoid score	I2678
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0016850
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_114803
Panther	1	1.100	-	-	LDO	PTHR10269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13660
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.880