Protein Alignment Gfrl and Gfra4

DIOPT Version :10

• Sequence 1: NP_001247206.1
• Gene: Gfrl / 3346162
• FlyBaseID: FBgn0262869
• Length: 1279
• Species: Drosophila melanogaster
• Sequence 2: NP_064398.1
• Gene: Gfra4 / 14588
• MGIID: 1341873
• Length: 302
• Species: Mus musculus
• Alignment Length: 278
• Identity: 63/278 - (22%)
• Similarity: 97/278 - (34%)
• Gaps: 84/278 - (30%)

  Fly   595 DNEPFDIIDTGLGYGGNGNAGVYYQSGQDVEVDLSTEIIKQHFQSTCHTALDTCREDPSCSSSLQ 659
            |..|...|..||| ...|:|.  :..|                 :.|..|.:.|..|..|.....
Mouse     9 DERPGQAIFLGLG-SQRGSAS--FTDG-----------------NRCVDAAEACTADERCQQLRS 53

  Fly   660 PMLTHCELHR-----------CNRNACMSSLQAFY-KGPHEDLNLDIAFCLCKKTSSQQNGNGNR 712
            ..:..| |.|           |.|:.|..:|:.|: :|| ..|...:.||.|:.::
Mouse    54 EYVARC-LGRAAPGGRPGPGGCVRSRCRRALRRFFARGP-PALTHALLFCGCEGSA--------- 107

  Fly   713 HDMCMIAQEKLHPVCAQRPPDNSNPA---SSNGIYYHPPPACHVVADSCKEDRECRLKLEYYEQA 774
                          ||:|......||   |..|:.   ||:|....:.|:..|.||.:|..::.:
Mouse   108 --------------CAERRRQTFAPACAFSGPGLV---PPSCLEPLERCERSRLCRPRLLAFQAS 155

  Fly   775 CA-VDSVTKKC--AGRPSGCRTAMIGILGTMLRTT--------------CACQGTDPQHLYQCVG 822
            || ......:|  .|.|. |.....|::||::...              ||..|...:   :|..
Mouse   156 CAPAPGSRDRCPEEGGPR-CLRVYAGLIGTVVTPNYLDNVSARVAPWCGCAASGNRRE---ECEA 216

  Fly   823 WRRLLWMNPCVVEAQKDF 840
            :|:|...|||:..|.:.|
Mouse   217 FRKLFTRNPCLDGAIQAF 234

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:460537
		GDNF	193..270	CDD:460537
		GDNF	641..727	CDD:197975	19/97 (20%)
		GDNF	751..832	CDD:460537	22/97 (23%)
Gfra4	NP_064398.1	GDNF	35..120	CDD:460537	23/109 (21%)
		GDNF	132..226	CDD:460537	22/97 (23%)