DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gfrl and Gfra3

DIOPT Version :9

Sequence 1:	NP_001247206.1	Gene:	Gfrl / 3346162	FlyBaseID:	FBgn0262869	Length:	1279	Species:	Drosophila melanogaster
Sequence 2:	NP_034410.3	Gene:	Gfra3 / 14587	MGIID:	1201403	Length:	397	Species:	Mus musculus

Alignment Length:	229	Identity:	54/229 - (23%)
Similarity:	88/229 - (38%)	Gaps:	61/229 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   640 TCHTALDTCRE--DPSCSSSLQPMLTHCELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKT 702
            |.|...|..|:  ..:||..           ||.|:.|::.|::|::...|.....:..|.|
Mouse   167 TLHDKCDRLRKAYGEACSGI-----------RCQRHLCLAQLRSFFEKAAESHAQGLLLCPC--- 217

  Fly   703 SSQQNGNGNRHDMCMIAQEKLHPVCAQRPPDNSNPASSNGIYYHPPPACHVVADSCKEDRECRLK 767
            :.:..|.|.|.      :..:.|.||.       |:.:        |.|..:...|:.|..||.:
Mouse   218 APEDAGCGERR------RNTIAPSCAL-------PSVT--------PNCLDLRSFCRADPLCRSR 261

  Fly   768 LEYYEQACAVDSVTKKCAGRPSGCRTAMIGILGTML--------RTT----CACQGT----DPQH 816
            |..::..|....:...||...|.|..|.:|::||.:        .||    |.|:|:    |
Mouse   262 LMDFQTHCHPMDILGTCATEQSRCLRAYLGLIGTAMTPNFISKVNTTVALSCTCRGSGNLQD--- 323

  Fly   817 LYQCVGWRRLLWMNPCVVE---AQKDFHMKRLAE 847
              :|....|....|||:||   |:..||.:..::
Mouse   324 --ECEQLERSFSQNPCLVEAIAAKMRFHRQLFSQ 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506
		GDNF	193..270	CDD:197975
		GDNF	641..727	CDD:197975	18/87 (21%)
		GDNF	751..832	CDD:280506	24/96 (25%)
Gfra3	NP_034410.3	GDNF	41..118	CDD:197975
		GDNF	159..236	CDD:280506	19/88 (22%)
		GDNF	245..337	CDD:280506	24/96 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840073
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940