DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gfrl and Gfra1

DIOPT Version :9

Sequence 1:	NP_001247206.1	Gene:	Gfrl / 3346162	FlyBaseID:	FBgn0262869	Length:	1279	Species:	Drosophila melanogaster
Sequence 2:	NP_034409.1	Gene:	Gfra1 / 14585	MGIID:	1100842	Length:	468	Species:	Mus musculus

Alignment Length:	364	Identity:	78/364 - (21%)
Similarity:	120/364 - (32%)	Gaps:	105/364 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 YQS--GQDVEVDLSTE--------------IIKQHFQ--------STCHTALDTCREDPSC---- 654
            |||  |.|:..|...|              .|...||        :.|..|...|..|.:|
Mouse   107 YQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKACNLDDTCKKYR 171

  Fly   655 SSSLQPMLTHCELHRCNRNACMSSLQAFYKGPHEDLNLDIAFCLCKKTSSQQNGNGNRHDMCMIA 719
            |:.:.|..|......|||..|..:|:.|:.......:..:.||.|:..:..:.           .
Mouse   172 SAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDVACTER-----------R 225

  Fly   720 QEKLHPVCAQRPPDNSNPASSNGIYYHPPPACHVVADSCKEDRECRLKLEYYEQACAVD--SVTK 782
            ::.:.|||:....:.              |.|..:.||||.:..||.:|..:...|..:  ||:.
Mouse   226 RQTIVPVCSYEERER--------------PNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSN 276

  Fly   783 KCAGRPSGCRTAMIGILGTMLRTT--------------CACQGTDPQHLYQCVGWRRLLWMNPCV 833
            ......:.|..|..|::||::...              |:..|.|   |..|:.:......|.|:
Mouse   277 CLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGND---LEDCLKFLNFFKDNTCL 338

  Fly   834 VEAQKDFHMKRLAELGFLTTTTTTTTTTTTTTTTTTTRAPPPPPPPTTTTTTTTSMQPRQTPRKP 898
            ..|.:.|                       ...:..|...|.||..|||.||||:.:.:..|..|
Mouse   339 KNAIQAF-----------------------GNGSDVTMWQPAPPVQTTTATTTTAFRIKNKPLGP 380

  Fly   899 A-------THIF---KDVITAKEKSEPTSVEHNYLDPPD 927
            |       ||:.   .::...|.||..:...|..|...|
Mouse   381 AGSENEIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDND 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506
		GDNF	193..270	CDD:197975
		GDNF	641..727	CDD:197975	18/89 (20%)
		GDNF	751..832	CDD:280506	22/96 (23%)
Gfra1	NP_034409.1	Repetitive region	25..113		3/5 (60%)
		GDNF	29..111	CDD:197975	3/3 (100%)
		Repetitive region	150..238		20/98 (20%)
		GDNF	154..233	CDD:197975	18/89 (20%)
		Repetitive region	239..342		24/119 (20%)
		GDNF	243..337	CDD:367047	22/96 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840077
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940