Protein Alignment Gfrl and gfra3

DIOPT Version :9

• Sequence 1: NP_001247206.1
• Gene: Gfrl / 3346162
• FlyBaseID: FBgn0262869
• Length: 1279
• Species: Drosophila melanogaster
• Sequence 2: XP_002936895.1
• Gene: gfra3 / 100489971
• XenbaseID: XB-GENE-988962
• Length: 416
• Species: Xenopus tropicalis
• Alignment Length: 474
• Identity: 94/474 - (19%)
• Similarity: 143/474 - (30%)
• Gaps: 166/474 - (35%)

  Fly    85 IKGVVAIL--------NCILARQLCFEDPSCSAILEIIPRVCGPIPVSCST--VTVTKCQAALRT 139
            |.|.|.||        :|:...|.|.:|..|::...|..        .||:  ::.::||.|...
 Frog    10 IAGTVTILYATTPAQSDCLQEEQACLQDVQCNSSYHIFQ--------DCSSGEMSSSRCQNAALV 66

  Fly   140 LQAFQFFRPTCLCKEPGMDPDCNHFR------------------DFLFDHP-----------CGF 175
            ||.    .|...||       |.|..                  |.:||..           ...
 Frog    67 LQE----SPLLGCK-------CQHRMRREEHCLNVYWTVHPVQDDLVFDESPYEESEFENMLTSE 120

  Fly   176 VLKKAEKDP--YPIDALPTCNHALSVCQQERKCLKLFEDFKTHCKVR--DNKCKMENRDACHDSW 236
            ..:..|.||  ..:|....|....::|....||.:....:.:.|..|  |..|   :|..||...
 Frog   121 YSRVIEDDPSLLSMDTDNVCLQQANICSSNNKCSRHKTSYASLCNQRNADGSC---DRRKCHRHL 182

  Fly   237 TNL--RLSPMFG-----CICPNNH------------------MKKRCDRIFNIVNHNPCVDRLI- 275
            .|.  ::|..|.     |.|..::                  .||.|.::     .:.||..::
 Frog   183 RNFFDKVSEEFTKRLLFCPCEESYCAERRRRTIVPECSFEEKSKKNCLQL-----QHSCVADIVC 242

  Fly   276 ------FFPNGLPKLKQPRPKAKPRPKPKPKSKPKPRQRHHGMNGTELMTNNIEYHDEPNGLSDP 334
                  |..|..  |.....|..|     |:......|.:..|.||.:..|.|.
 Frog   243 RSHLADFQKNCF--LSDKTSKECP-----PEKYGACLQSYIRMIGTVMTPNYIN----------- 289

  Fly   335 EDEANETVDED----PGGHGDEDED--------EEDDDYDDRIRAEIYSNYPHYLHPPSWGINNP 387
                |.::|..    ..|.|::.||        ..:..:.:.|.|||    ..|..|....|..|
 Frog   290 ----NSSMDVSLWCTCDGSGNQREDCNTVLGMFANNRCFKNAIAAEI----NRYTQPQPEVIPQP 346

  Fly   388 LVLASHSPHTLDDDDDVVVEVVANKKPPPVTLHHHNDELDHDVVVVVDAGPHSHSHPHSHTFYSH 452
            ..:...:|....|.|:  .||..:.|   |.:.:.||..|.                     .|:
 Frog   347 STVVISAPVKATDQDN--FEVDGSTK---VLIPNINDGADK---------------------ASY 385

  Fly   453 GDQSSTTGSGLPGPAPTIP 471
            |..::.:|...|..|.|:|
 Frog   386 GKSNTASGVSCPSLALTLP 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gfrl	NP_001247206.1	GDNF	94..173	CDD:280506	21/109 (19%)
		GDNF	193..270	CDD:197975	19/103 (18%)
		GDNF	641..727	CDD:197975
		GDNF	751..832	CDD:280506
gfra3	XP_002936895.1	GDNF	27..95	CDD:197975	18/86 (21%)
		GDNF	140..219	CDD:367047	16/81 (20%)
		GDNF	229..323	CDD:367047	21/120 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10269
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010