DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment dpr4 and PAPLN

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001352835.1	Gene:	PAPLN / 89932	HGNCID:	19262	Length:	1278	Species:	Homo sapiens

Alignment Length:	349	Identity:	75/349 - (21%)
Similarity:	103/349 - (29%)	Gaps:	138/349 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GEVPPH---YWETPYSQ-----------------PYFDNSSRR---------EVTATVGQAALLH 66
            ||. ||   :.|.|:.|                 |.|.:||.|         .|.|.:||...|.
Human   867 GEA-PHTQAFGEWPWGQELGSRAPGLGGDAGSPAPPFHSSSYRISLAGVEPSLVQAALGQLVRLS 930

  Fly    67 CRVRNLGDRAVSWIR-----KRDLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSPQPRDSGT 126
            |......:...:|.:     ..|.|                .|..:||    |.|...|..|:||
Human   931 CSDDTAPESQAAWQKDGQPISSDRH----------------RLQFDGS----LIIHPLQAEDAGT 975

  Fly   127 YECQVSTEP-KISQGFRLNVVVSRAKILGNAELF------------------------------- 159
            |.|. ||.| :.||..:|.::.....:|..|||.
Human   976 YSCG-STRPGRDSQKIQLRIIGGDMAVLSEAELSRFPQPRDPAQDFGQAGAAGPLGAIPSSHPQP 1039

  Fly   160 ---------------IKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERS--T 207
                           ...|..|.:||.|  ...||..|.|          ||.|..|.:.|.  .
Human  1040 ANRLRLDQNQPRVVDASPGQRIRMTCRA--EGFPPPAIEW----------QRDGQPVSSPRHQLQ 1092

  Fly   208 RTSKLLIAKATPADSGNYTC---SPSSSDSASVVVHV-----INGEHPAAMQHGNSSATCLRPLS 264
            ....|:|::....|.|.|||   :....|...|.:.|     |:|..|........:|..|..::
Human  1093 PDGSLVISRVAVEDGGFYTCVAFNGQDRDQRWVQLRVLGELTISGLPPTVTVPEGDTARLLCVVA 1157

  Fly   265 STSVPFVLATWMSMTVASVAWNSN 288
            ..||             ::.|:.|
Human  1158 GESV-------------NIRWSRN 1168

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	27/107 (25%)
		IG_like	53..145	CDD:214653	27/106 (25%)
		ig	153..227	CDD:278476	23/121 (19%)
		IG_like	161..>227	CDD:214653	19/67 (28%)
PAPLN	NP_001352835.1	TSP1	29..80	CDD:214559
		ADAM_spacer1	183..298	CDD:310520
		TSP1	308..361	CDD:214559
		TSP1	369..424	CDD:214559
		TSP1	424..481	CDD:214559
		TSP1	488..539	CDD:214559
		Kunitz_BPTI	753..805	CDD:278443
		Papilin_u7	814..905	CDD:318767	9/38 (24%)
		Ig	914..>978	CDD:325142	19/83 (23%)
		I-set	1049..1119	CDD:254352	21/81 (26%)
		IG	1139..1219	CDD:214652	7/43 (16%)
		PLAC	1235..1267	CDD:312271
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900