DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and IGSF9

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001128522.1	Gene:	IGSF9 / 57549	HGNCID:	18132	Length:	1179	Species:	Homo sapiens

Alignment Length:	245	Identity:	58/245 - (23%)
Similarity:	93/245 - (37%)	Gaps:	59/245 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 PPHYWETPYSQPYFDNSSRREVTATVGQAALLHCRVRNLGDRAVSW-IRKRDLHILTVGILTYTN 97
            ||.:.|||  ....:......||        |.|..|......|:| :|.:||
Human   135 PPQFQETP--PAVLEVQELEPVT--------LRCVARGSPLPHVTWKLRGKDL------------ 177

  Fly    98 DQRFQSLHSEGSDE-----WTLRISSPQPRDSGTYECQV-STEPKISQGFRLNVVVSRAKILGNA 156
                    .:|..:     .||||...:...||.|.||. |||...:...:|.|:.....::...
Human   178 --------GQGQGQVQVQNGTLRIRRVERGSSGVYTCQASSTEGSATHATQLLVLGPPVIVVPPK 234

  Fly   157 ELFIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQ-RGGINVITERSTRTSKLLIAKATPA 220
            ...:.:..|::|.|.|...|...::.::.....|.:.|: :..:.::.:.|.|    |:| ..|.
Human   235 NSTVNASQDVSLACHAEAYPANLTYSWFQDNINVFHISRLQPRVRILVDGSLR----LLA-TQPD 294

  Fly   221 DSGNYTCSPSSSDSASVVVHVING-EHPAAMQHGNSSATCLRPLSSTSVP 269
            |:|.|||.||            || .||.:   .::..|.|.|...|::|
Human   295 DAGCYTCVPS------------NGLLHPPS---ASAYLTVLYPAQVTAMP 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	24/99 (24%)
		IG_like	53..145	CDD:214653	24/98 (24%)
		ig	153..227	CDD:278476	15/74 (20%)
		IG_like	161..>227	CDD:214653	15/66 (23%)
IGSF9	NP_001128522.1	Ig	24..132	CDD:299845
		IG_like	28..110	CDD:214653
		I-set	136..223	CDD:254352	28/116 (24%)
		Ig	154..220	CDD:143165	23/93 (25%)
		Ig_3	226..305	CDD:290638	19/95 (20%)
		IG_like	233..319	CDD:214653	23/105 (22%)
		Ig	341..404	CDD:299845
		IG_like	431..503	CDD:214653
		Ig	436..500	CDD:143165
		fn3	511..596	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	606..626
		FN3	625..715	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..919
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	940..988
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1079
		PDZ-binding. /evidence=ECO:0000250	1177..1179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810