DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	289	Identity:	71/289 - (24%)
Similarity:	114/289 - (39%)	Gaps:	75/289 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LWLLLFLDCGMVGGEVPPHYWETPYSQPYFDNSSRREVTATVGQAALLHCRVRNLGDRAVSWIRK 82
            :|:|...|....|       .:|.:||...|.      |...||.|:|.|.:.|..
Human     6 VWILTLSDTFSQG-------TQTRFSQEPADQ------TVVAGQRAVLPCVLLNYS--------- 48

  Fly    83 RDLHILTVGILTYTND-------------QRFQSLHSEGSDEWTLRISSPQPRDSGTYECQVSTE 134
                    ||:.:|.|             .|::.:.|..:.::.|.|:..:..|..:||||.:..
Human    49 --------GIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEA 105

  Fly   135 PKISQGFRLNVVV--SRAKILGNAELFIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRG 197
            ...|:..:|.|::  ...:|.|...:.:::|:..||||.|..:. |.:.|.|::     :.:|:.
Human   106 ALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPHNLTCRAFNAK-PAATIIWFR-----DGTQQE 164

  Fly   198 GINVITE------RSTRTSKLLIAKATPADSGN-YTCS------PSSSD-SASVVVH----VING 244
            |....||      |.|..|:||| ..|..|.|. :||.      ||..: |..:.||    |...
Human   165 GAVASTELLKDGKRETTVSQLLI-NPTDLDIGRVFTCRSMNEAIPSGKETSIELDVHHPPTVTLS 228

  Fly   245 EHPAAMQHGNSSA-TCLRPLSSTSVPFVL 272
            ..|..:|.|.... ||    .:|:.|.:|
Human   229 IEPQTVQEGERVVFTC----QATANPEIL 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	22/105 (21%)
		IG_like	53..145	CDD:214653	22/104 (21%)
		ig	153..227	CDD:278476	23/80 (29%)
		IG_like	161..>227	CDD:214653	22/72 (31%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	25/116 (22%)
		Ig	25..116	CDD:299845	24/113 (21%)
		Ig2_KIRREL3-like	138..219	CDD:143236	26/87 (30%)
		I-set	223..304	CDD:254352	9/35 (26%)
		Ig_2	227..305	CDD:290606	8/31 (26%)
		Ig_2	311..405	CDD:290606
		IG_like	314..405	CDD:214653
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810