DRSC/TRiP Functional Genomics Resources

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Protein Alignment dpr4 and NTM

DIOPT Version :9

Sequence 1:NP_001014616.2 Gene:dpr4 / 3346160 FlyBaseID:FBgn0053512 Length:323 Species:Drosophila melanogaster
Sequence 2:NP_001338930.1 Gene:NTM / 50863 HGNCID:17941 Length:367 Species:Homo sapiens


Alignment Length:310 Identity:68/310 - (21%)
Similarity:110/310 - (35%) Gaps:110/310 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 VTATVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSP 119
            ||...|::|.|.|.:.|...| |:|:.:..  ||..|...:..|.|...| |....::::.|.:.
Human    45 VTVRQGESATLRCTIDNRVTR-VAWLNRST--ILYAGNDKWCLDPRVVLL-SNTQTQYSIEIQNV 105

  Fly   120 QPRDSGTYECQVSTE--PKISQGFRLNVVVSRAKILGNAELFIKSGSDINLTCLAMQSPVP---- 178
            ...|.|.|.|.|.|:  ||.|: ..|.|.||...:..::::.|..|::|:|||:|...|.|    
Human   106 DVYDEGPYTCSVQTDNHPKTSR-VHLIV
QVSPKIVEISSDISINEGNNISLTCIATGRPEPTVTW 169

  Fly   179 ----------------------------------------------------PSFI--------- 182
                                                                |.:|         
Human   170 RHISPKAVGFVSEDEYLEIQGITREQSGDYECSASNDVAAPVVRRVKVTVNYPPYISEAKGTGVP 234

  Fly   183 -------------------YWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKATPADSGNYTCS 228
                               .|||..:.:...::|   |..|.....|||:....:..|.|||||.
Human   235 VGQKGTLQCEASAVPSAEFQWYKDDKRLIEGKKG---VKVENRPFLSKLIFFNVSEHDYGNYTCV 296

  Fly   229 PSSS---DSASVVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATW 275
            .|:.   .:||:::..:|  .|       :|:|.|:.:.:|:    |..|
Human   297 ASNKLGHTNASIMLFELN--EP-------TSSTLLQEVKTTA----LTPW 333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
dpr4NP_001014616.2 V-set 53..146 CDD:284989 28/92 (30%)
IG_like 53..145 CDD:214653 28/91 (31%)
ig 153..227 CDD:278476 24/157 (15%)
IG_like 161..>227 CDD:214653 23/149 (15%)
NTMNP_001338930.1 Ig 44..132 CDD:416386 28/91 (31%)
Ig strand A' 44..49 CDD:409353 2/3 (67%)
Ig strand B 51..59 CDD:409353 3/7 (43%)
CDR1 59..63 CDD:409353 1/3 (33%)
FR2 64..70 CDD:409353 3/6 (50%)
Ig strand C 64..70 CDD:409353 3/6 (50%)
CDR2 71..83 CDD:409353 3/13 (23%)
Ig strand C' 72..76 CDD:409353 1/5 (20%)
Ig strand C' 80..83 CDD:409353 0/2 (0%)
FR3 84..118 CDD:409353 9/34 (26%)
Ig strand D 87..94 CDD:409353 3/7 (43%)
Ig strand E 97..103 CDD:409353 0/5 (0%)
Ig strand F 110..118 CDD:409353 3/7 (43%)
CDR3 119..123 CDD:409353 1/3 (33%)
Ig strand G 123..132 CDD:409353 4/9 (44%)
FR4 125..132 CDD:409353 2/7 (29%)
Ig_3 136..205 CDD:404760 9/68 (13%)
Ig strand A' 142..147 CDD:409353 0/4 (0%)
Ig strand B 153..160 CDD:409353 4/6 (67%)
Ig strand C 166..171 CDD:409353 0/4 (0%)
Ig strand D 177..180 CDD:409353 0/2 (0%)
Ig strand E 184..190 CDD:409353 0/5 (0%)
Ig strand F 197..204 CDD:409353 0/6 (0%)
Ig strand G 211..219 CDD:409353 0/7 (0%)
Ig_3 222..299 CDD:404760 17/79 (22%)
putative Ig strand A 223..229 CDD:409353 1/5 (20%)
Ig strand B 239..243 CDD:409353 0/3 (0%)
Ig strand C 252..256 CDD:409353 0/3 (0%)
Ig strand E 278..282 CDD:409353 3/3 (100%)
Ig strand F 292..297 CDD:409353 4/4 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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