DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and NCAM1

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	NP_001229536.1	Gene:	NCAM1 / 4684	HGNCID:	7656	Length:	884	Species:	Homo sapiens

Alignment Length:	389	Identity:	73/389 - (18%)
Similarity:	131/389 - (33%)	Gaps:	123/389 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 LWLLLFLDCGM-VGGEVPPHYWETPYSQPYFDNSSRREVTATVGQAALLHCRVR-NLGDRAVSWI 80
            :|.|.||...: :..::.|               |:.|:  :||::....|:|. :..|:.:||.
Human     8 IWTLFFLGTAVSLQVDIVP---------------SQGEI--SVGESKFFLCQVAGDAKDKDISWF 55

  Fly    81 RKRDLHILTVGILTYTNDQRFQSLHSEGSDEWTLRISSPQPRDSGTYECQVSTEPKISQGFRLNV 145
            ...       |.....|.||...:.::.|.. ||.|.:....|:|.|:|.|:.|........:||
Human    56 SPN-------GEKLTPNQQRISVVWNDDSSS-TLTIYNANIDDAGIYKCVVTGEDGSESEATVNV 112

  Fly   146 VVSRAKILGNAEL--FIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVM------------NYSQR 196
            .:.:..:..||..  ..:.|.|..:.|..:.| :||:.|:.:||:.|:            ||.|.
Human   113 KIFQKLMFKNAPTPQEFREGEDAVIVCDVVSS-LPPTIIWKHKGRDVILKKDVRFIVLSNNYLQI 176

  Fly   197 GGINVITERSTRTSKLLIAK----------------------------ATPADSGNYTCSPS--- 230
            .||....|.:.|....::|:                            |....|....|...
Human   177 RGIKKTDEGTYRCEGRILARGEINFKDIQVIVNVPPTIQARQNIVNATANLGQSVTLVCDAEGFP 241

  Fly   231 ------------------------SSDSASVVVHVINGEHPAAM------QHGNSSATC-LRPLS 264
                                    |.||:.:.:..::....|..      :.|...||. |:..:
Human   242 EPTMSWTKDGEQIEQEEDDEKYIFSDDSSQLTIKKVDKNDEAEYICIAENKAGEQDATIHLKVFA 306

  Fly   265 STSVPFV-------LATWMSMT-------VASVAW-NSNLNIN----WNWSPDWRWHWNPKWNW 309
            ...:.:|       |...:::|       :.|:.| .|..||:    .:|:...:...:..|||
Human   307 KPKITYVENQTAMELEEQVTLTCEASGDPIPSITWRTSTRNISSEEKASWTRPEKQEVHAPWNW 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	23/93 (25%)
		IG_like	53..145	CDD:214653	22/92 (24%)
		ig	153..227	CDD:278476	22/115 (19%)
		IG_like	161..>227	CDD:214653	20/105 (19%)
NCAM1	NP_001229536.1	Ig1_NCAM-1	20..115	CDD:143273	26/119 (22%)
		IG	124..190	CDD:214652	17/66 (26%)
		Ig	211..307	CDD:325142	11/95 (12%)
		Ig	306..438	CDD:325142	12/65 (18%)
		Ig_3	447..519	CDD:316449
		FN3	534..631	CDD:238020
		fn3	639..720	CDD:306538
		Trypan_PARP	<792..>864	CDD:330686
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810