DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dpr4 and Sdk2

DIOPT Version :9

Sequence 1:	NP_001014616.2	Gene:	dpr4 / 3346160	FlyBaseID:	FBgn0053512	Length:	323	Species:	Drosophila melanogaster
Sequence 2:	XP_006247755.1	Gene:	Sdk2 / 360652	RGDID:	1310397	Length:	2175	Species:	Rattus norvegicus

Alignment Length:	275	Identity:	65/275 - (23%)
Similarity:	107/275 - (38%)	Gaps:	69/275 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PYFDNSSRREVTATVGQAALLHCRVRNLGDRAVSWIRKRDLHILTVGILTYTNDQRFQSLHSEGS 109
            |.|.....|.:||.:.:...:.||.:.:...:::|.  :|..::.||.||     ||:. .|:|.
  Rat   311 PQFVREPERHITAEMEKVVDIPCRAKGVPPPSITWY--KDAALVEVGKLT-----RFKQ-RSDGG 367

  Fly   110 DEWTLRISSPQPRDSGTYEC---------QVST-------EPKISQGFRLNVVVSRAKILGNAEL 158
                |:||...|.|:|..:|         |.||       .|.|::|...:.|:
  Rat   368 ----LQISGLLPDDTGMVQCFAHNAAGEAQTSTYLAVTSIAPNITRGPLDSTVI----------- 417

  Fly   159 FIKSGSDINLTCLAMQSPVPPSFIYWYKGKRVMNYSQRGGINVITERSTRTSKLLIAKATPADSG 223
               .|..:.|.|....:|.|.  |.|.||:|::   ..|.:.:.......:..|||:....:|:|
  Rat   418 ---DGMSVVLACETSGAPRPA--ITWQKGERIL---ASGSVQLPRFTLLESGSLLISPTHISDAG 474

  Fly   224 NYTCSPSSS-----DSASVVVHVINGEHPAAMQHGNSSATCLRPLSSTSVPFVLATWMSMTVASV 283
            .|||..::|     .||.:||.              :.....:|....||  :..|..|| |..|
  Rat   475 TYTCLATNSRGVDEASADLVVW--------------ARTRITKPPQDQSV--IKGTQASM-VCGV 522

  Fly   284 AWNSNLNINWNWSPD 298
            ..:..:.:.:.|..|
  Rat   523 THDPRVTVRYVWEKD 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dpr4	NP_001014616.2	V-set	53..146	CDD:284989	28/108 (26%)
		IG_like	53..145	CDD:214653	28/107 (26%)
		ig	153..227	CDD:278476	17/73 (23%)
		IG_like	161..>227	CDD:214653	17/65 (26%)
Sdk2	XP_006247755.1	IG_like	43..112	CDD:214653
		IGc2	43..101	CDD:197706
		IG_like	123..206	CDD:214653
		Ig	135..191	CDD:299845
		IG_like	225..307	CDD:214653
		IGc2	236..289	CDD:197706
		I-set	311..400	CDD:254352	27/100 (27%)
		Ig	329..397	CDD:143165	21/79 (27%)
		I-set	405..495	CDD:254352	26/108 (24%)
		Ig	419..495	CDD:299845	22/80 (28%)
		Ig	505..589	CDD:299845	9/36 (25%)
		IG_like	505..589	CDD:214653	9/36 (25%)
		FN3	593..684	CDD:238020
		FN3	696..789	CDD:238020
		FN3	797..893	CDD:238020
		FN3	898..986	CDD:238020
		FN3	996..1090	CDD:238020
		FN3	1102..1197	CDD:238020
		FN3	1204..1293	CDD:238020
		FN3	1304..1397	CDD:238020
		FN3	1403..1487	CDD:238020
		FN3	1506..1619	CDD:238020
		FN3	1629..1722	CDD:238020
		FN3	1727..1808	CDD:238020
		FN3	1840..1919	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810